This document contains a dental examination report for a 14-year-old male patient. The patient's chief complaint is that his upper front teeth appear too prominent. The examination found a Class II malocclusion with increased overjet and overbite. Treatment aims to improve oral hygiene, restore cavities, enhance mandibular growth, and achieve a Class I occlusion. The proposed treatment plan is non-extraction with initial Twin Block appliance therapy followed by fixed appliance treatment using a pre-adjusted edgewise Roth prescription to align the teeth and improve the bite. Retention will include lower fixed and upper/lower removable retainers.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
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share - Lions, tigers, AI and health misinformation, oh my!.pptx
Dr-Osama case presentation
1. Personal data
Patient’s name :M.S
Gender : Male
Date of Birth: 20th Mar 2003
Age: 14 years
Nationality: Jordanian
2. Medical & Dental History
Medical History:
denied any medical problems .
Dental History:
Previous visits to dental clinic for check-ups
previous root canal treatment in upper right
first molar before a year .
Habits: No habits noticed or mentioned
Motivation: Highly motivated.
Expectations: High expectations.
4. Jaw & Occlusal Function
Mastication: Normal masticatory
pattern.
Speech:
Normal flow of speech.
No difficulties detected
TMJ:
No signs of TMJ dysfunction (No clicking,
no crepitus, no tenderness to palpation)
Good range of opening
Good range of lateral movement
15. Intra-oral Examination:
• Teeth present
7654321 1234567
7654321 1234567
• Fair oral hygiene.
• Generalized fluorosis.
• Gingival inflamed and swollen in both U&L ant. Region.
16. Lower Arch:
A. U shape arch.
B. Anterior segment:
well aligned teeth.
C. Posterior segment:
rotated R&L 2nd premolars.
carious teeth
765 46
17. Upper Arch:
A. U shape Arch
B. Anterior segment:
slight proclined upper incisors.
slight displaced palatally UR2.
C. Posterior segment:
rotated UR&L 1st premolars.
broken restoration UR 1st molar.
carious teeth:
7 4 67
18. Anterior segment
• Class II/1 incisor relationship.
• Midline is not coincident.
• Upper midline shift to the right side
1mm.
• Lower midline shift to the right side
2mm.
• Overjet: 7mm.
• Overbite: incomplete deep bite 70%.
19. Buccal segment
Molar relationship : class II ½ unit in Rt & Lt sides.
Canine relationship : class II ½ unit in Rt& Lt sides.
20.
21.
22. Molar relation : CII ½
Canine relation : CII ½
No crossbite .
23. Molar relation : CII ½
Canine relation : CII ½
No crossbite .
24. • lower incisor edges are palatal to the cingulum plateau of the upper incisors .
• Incomplete deep overbite .
25. • U shape arch .
• Inter canine width
(3—3 ) = 27 mm.
• Intermolar width
(6—6) = 45 mm.
27mm
45 mm
26. • U shape Arch.
• Inter canine width (3 – 3) = 34 mm
• Inter molar width (6 – 6) = 49 mm
34 mm
35. VII) Dental component
• Upper dental midline is not coincide with facial midline.
• Crown angulation parallelism is not coincident .
36. VIII)Gingival contour
• Gingival margin of upper Rt canine is higher than central incisors .
• Gingival margin of upper Rt lateral incisor is more near to the level of
upper central incisor .
Not
Accepted
37. Space analysis
Lower arch:
space available = 71
space required = 71
No crowding
Upper arch :
space available =83
space required=80
(+3 ) = spacing
39. Bolton Ratio
There is increased in the lower anterior teeth.
)(%83
%100
48
40
%100
)33(
)33(
inceased
Max
Mand
RatioBoltonAnterior
)(%5.85
%100
83
71
%100
)66(
)66(
reduced
Max
Mand
RatioBoltonOverall
40. Index Of Orthodontic Treatment Need
(IONT)
Figure 1
41. Index Of Orthodontic Treatment Need (IOTN)
• Grade 4
4a. Increase overjet > 6mm
but < 9mm.
42. -All teeth are present including 3rd molars.
-Condyles are in normal shape and position.
-Normal Maxillary sinuses.
-No bony pathology.
-RCT on UR 6.
43. Cervical Vertebral Maturation
CS4 :
Peak of mandibular
growth has occurred
within 1 or 2 yrs.'
before this stage .
25% - 10% remaining.
45. Diagnostic summary
A 13 years old male, denied any medical problem, presented with concern
about the appearance of his upper front teeth are too prominent. he had
fair oral hygiene, multiple carious teeth, gingival inflammation in both
U&L ant. teeth, generalized fluorosis and broken filling with RCT on UR6.
He exhibited a class II div I incisors malocclusion on class II skeletal base,
with convex profile, average lower face height, incompetent lips and wide
buccal corridors.
Dentally, he has increased overjet 7mm ,incomplete deep overbite 70% ,well
aligned lower arch, spaced upper arch 3mm with slightly proclined upper
& lower incisors, slightly displaced UR2, rotated UR&L 1st premolars &
LR&L 2nd premolars, U&L midline shift to the right side, both molars &
canines are classII ½ unit relationship, increased Bolton ratio and curve
of spee of 3mm.
46. Problem list
Pathological problems:
• Fair O.H.
• Generalized fluorosis.
• Multiple carious teeth.
• Gingival inflammation of U & L ant. region.
• Broken restoration on UR6.
Patient’s concern:
My upper anterior teeth are too prominent.
Skeletal problems:
• Class II skeletal base.
{ Retro gnathic mandible }
Soft tissue problems:
• Incompetent lips.
• Convex profile.
• Asymmetrical face.
• Nose deviation to right side.
Dental problems:
• Increased overjet 7mm.
• Incomplete deep overbite 70%.
• Slightly proclined upper incisors
and displaced UR2.
• proclined lower incisors .
• Rotated U R&L1st premolars and
L R&L2nd premolars.
• Both midlines are shift to the
right side.
• Class II/I incisor relationship.
• Both molars and canines have
classII ½ unit relationship.
• Increased anterior Bolton ratio.
• Increased curve of spee 3mm.
47. Treatment Aims
Improve oral hygiene.
Restore carious teeth and broken restoration on UR6.
Give the patient the desired appearance.
Enhance forward growth of the mandible to improve facial profile and
mandible/cranial base relationship.
Improve lip competency.
Accept other soft tissue problems.
Reduce overjet and overbite.
Correction of upper & lower incisors inclination .
Achieve class I molar and canine relationship.
Achieve class I incisor relationship.
Correction of rotated teeth.
Correction the midline.
Correction of anterior Bolton discrepancy.
Correction of curve of spee.
48. Treatment plan:- “ Non Extraction Case”
O. H. I .
Refer to perio. Clinic.
Refer to cons. Clinic .
1st phase :-
Functional appliance “ Twin Block appliance” .
2nd phase :-
Upper & Lower Fixed Appliance
“ Pre-adjusted edgewise Roth prescription slot 0.022”
Stripping in the lower anterior teeth.
Retention:-
o Lower fixed retainer.
o Conventional upper and lower Hawley Retainer.
49. Justification:-
I. Refer to perio clinic for management of gingival inflammation .
II. Refer to cons clinic to restore multiple carious teeth and broken restoration in UR6.
III. Growth modification appliance treatment :
Growing patient.
motivated patient.
uncrowded, well aligned teeth .
Dentally Cl ll/1 on mild Skeletal Cl II base due to deficient mandible (low SNB).
Good vertical facial proportions.
50. Twin Block appliance:
Esthetics and comfort &
Full time wear because the twin block appliances are not bulky.
Modification in Twin block design :
incorporated with expansion screw to maintain normal transverse relation .
incorporated with lower incisor capping to prevent more proclination in the lower
anterior teeth.
Full time wearing the appliance
Revaluate the case every 3 months with cephalometric superimposition to evaluate
the progress .
At the end of first phase of treatment a simple upper appliance with an anterior
inclined plane was given to be worn full time for 3 - 6 months to maintain the
skeletal corrections.
51. IV. Non-extraction :
growing patient .
No crowding in the upper and lower arch's.
space will be provided from stripping and de-rotation of rotated teeth
V. Fixed appliance using Roth prescription:
For 3D tooth movement , and average torque needed .
correction of midline “ either by stripping Or deferential elastics ’’
Derotation of rotated teeth .
Correction of anterior Bolton discrepancy .
Improve the smile aesthetics “reduce the wide buccal corridor by arch wire
expansion , extrusion of UR3 for gingival contour correction’’.
Final finishing detailing .
52. VI. Retention :
• Long term : lower anterior fixed retainer:
For more stability of lower incisors .
• Short term: upper and lower Hawley retainer :
Upper and Lower Hawley 6month full time wear and 6 month night
time .
For more settling and stability of overjet and overbite.