This document summarizes several plant-derived toxins that cause organic irritant poisoning, including ricin from Ricinus communis, crotin from Croton tigilium, and abrin from Abrus precatorius. It provides details on their mechanisms of action, such as ricin inhibiting RNA polymerase and abrin inhibiting protein synthesis. The document also discusses toxins from other plants like ergotamine from ergot fungi, capsaicin from Capsicum annum, and cantharidin from blister beetles.

1. Organic irritantOrganic irritant
poisoningpoisoning

2. Toxalbumin /Toxalbumin /
phytotoxinphytotoxin
 RicinRicin
 CrotinCrotin
 AbrinAbrin

3. Ricinus communisRicinus communis
 ToxalbuminToxalbumin
/phytotoxin/phytotoxin
 RicinRicin
 Castor oil is nonCastor oil is non
poisonouspoisonous
 Press cake isPress cake is
poisonouspoisonous
 MOA – inhibitsMOA – inhibits
RNAPRNAP
 Special BPSpecial BP  ErEr
GITGIT  DiarrhoeaDiarrhoea

4. Croton tigiliumCroton tigilium
 CrotinCrotin

5. Abrus precatoriusAbrus precatorius
 AbrinAbrin
 Similar toSimilar to
viperin snakeviperin snake
venomvenom
 HemagglutininHemagglutinin
 LipolyticLipolytic
enzymesenzymes
 MOA – inhibitsMOA – inhibits
 ProteinProtein
synthesissynthesis

6. ErgotismErgotism
 Ergotoxin,ergotaminErgotoxin,ergotamin
e ,ergometrinee ,ergometrine
 StimulateStimulate
adrenergicadrenergic
receptors –receptors –
periphery andperiphery and
centrecentre
 Directly stimulateDirectly stimulate
muscle fibresmuscle fibres

7. Ergotism – chronicErgotism – chronic
poisoningpoisoning

8. Capsicum annumCapsicum annum
--capsaicin ,capsicincapsaicin ,capsicin

9. SemicarpusSemicarpus
anacardiumanacardium
 SemicarpolSemicarpol
 BhilawanolBhilawanol

10. CalotropisCalotropis
 UscharinUscharin
 CalotoxinCalotoxin
 CalctinCalctin
 calotropincalotropin

11. CantharidesCantharides
 Spanish fly / Blister beetleSpanish fly / Blister beetle
 CantheridinCantheridin