The document proposes a methodology for optimal extraction of integrated clinical informatics data from various web sources to support precision medicine. It involves collecting 4D medical data through unique IDs, extracting text from different file formats, integrating data through SQL queries, and verifying/validating the integrated data. The methodology was tested on a COVID-19 dataset and achieved a 76% success rate in reducing active cases through precision treatment approaches enabled by optimal data extraction and integration from clinical informatics sources.