This chapter discusses linear regression and the least squares regression line (LSRL). The LSRL is a straight line that minimizes the vertical distance between the data points and the line. It serves as a mathematical model for predicting a response variable (y) based on an explanatory variable (x). The coefficient of determination (r^2) indicates how much of the variation in y is explained by the linear relationship with x. Residual plots and identifying outliers and influential points are also covered.