Benjamin List (Germany) and David MacMillan (US) received the Noble prize in Chemistry 2021 for their development of a precise new tool for molecular construction-the organocatalysis. https://www.nobelprize.org/prizes/chemistry/2021/prize-announcement/ #Nobleprize2021 #Chemistry https://youtu.be/rY7zNkjly7Y

1. -Dr. Mithil Fal Desai
Assistant Professor in Chemistry (Contract)
Shree Mallikarjun and Shri Chetan Manju
Desai College Canacona Goa
Let us
know
little
about it!

2. Achiral
molecules
Chiral
molecules
• Metal catalyst
• Enzyme catalyst
• Asymmetric
organo catalyst
What an organo catalyst does in
asymmetric synthesis?
Asymmetric organo catalyst helps in the synthesis of chiral molecules like
other catalysts (Metal/Enzyme).

3. Some advantages of asymmetric organo
catalysts
• Simple structures
• Inexpensive
• Natural molecules
• Non toxic

4. Reactants
Products
Ea1 without catalyst
Ea2 with catalyst
Energy
Reaction coordinates
Catalyst
Catalyst is a substance
that increases the rate
of a reaction without
itself being consumed.

5. Asymmetric organic compound
Organic compound having asymmetric carbon atom/s is called as
asymmetric organic compound.
*
Non asymmetric
organic compound
Asymmetric
organic compound
Carbon atom
attached to
similar atoms.
Carbon atom
attached to all
different atoms.
Achiral molecule Chiral molecule

6. Why chiral centre is so important?
R-Lemonene S-Lemonene
Smells orange Smells lemon
* *
Chiral property of organic molecules plays a vital role in the recognition
phenomenon between the biologically active molecule and its target.