This document discusses how nanoparticles can be used for targeted drug delivery in cancer and inflammation. Nanoparticles less than 100nm in size can be engineered from biodegradable materials to efficiently carry drugs and be taken up by targeted cells. They allow for higher doses of drugs to be delivered directly to diseased cells over prolonged periods of time, reducing side effects. Examples discussed include using nanoparticles to target cancer cells, tumor angiogenesis, infected macrophages, and inflammatory molecules. The future potential of nanotechnology for improved targeted drug delivery is promising.

2. • INTRODUCTION
• DESIGN
• DELIVERY OF SI-RNA THROUGH NANOPARTICLE
• CANCER
TARGETTING CANCER CELL
TARGETTING ANGIOGENESIS
• NANOSYSTEMS IN INFLAMMATION
TARGETTING MACROPHAGES
TARGETTING INFLAMMATORY MOLECULES
• SUMMARY

3. • Nano-particles size <100nm
• Biodegradable materials
Synthetic polymers
lipids
metals
• Efficiently carried by cells for transport
• Achieves efficiency on interaction with bio-environment
• Internally reduced efficacy due to
Instability
Unavailability due to multiple targeting
Chemical properties of delivering molecules
Alterations in gene
In this review we discuss the drug delivery aspects of NANOMEDICINE, the
molecular mechanisms underlying the interactions of nanoparticle with cell
surface receptors, biological responses and cell signalling

5. • Delivers drug to the targeted cell.
• In case of untargeted drug delivery system, the drug is
partially delivered to the infected cell.
• Interaction of NANOTUBES with cell receptors targets the
infected cell.
• For example : Anti-cancer drugs like PACKLITAXEL [10,11],
doxorubicin[12], 5-fluorouracil[13] and DEXAMETHASONE.
• NANOPARTICLE releases higher doses of drugs for
prolonged period of time completely inhibited proliferation
of vascular smooth muscle cells.
• PACLITAXEL bound to bio-compatible proteins like albumin
is an INJECTABLE NANO-SUSPENSION approved for the
treatment for breast cancer.

6. • SIRNA –robust method of controlling gene expression .
• CHITOSAN used to deliver human epidermal growth factor
receptor-2 SIRNA
• HER2 SIRNA (antibody) labelled with CHITOSAN targets
the HER2 receptors on SKBR3 cells.
• Labelling of NANOPARTICLES with a fluorescent marker
helps in visualizing uptake and accumulation of
NANOTUBES.
• Effective in vivo RNA interference was achieved in
bronchiolar epithelial cells.

7. • Brain cancer is difficult to detect and treat because of the
difficulty in getting imaging and therapeutic agents across
the blood-brain barrier and into the brain.
• NANOPARTICLE ferries such agents into the brain.
• A tiny polymer (NANOPARTICLE) acts against cancer.
• Immobilize the surface of the cancer cell.
• Visualize the target using MRI.
• Delivers toxins to destruct the cancer cell.
• NANOMATERIALS holds tremendous potential to target
tumour cells

8. • Robust angiogenesis underlies aggressive growth of
tumour
• Targeting angiogenesis with NANOPARTICLE inhibits the
angiogenesis and starves tumour cells.
• CHITOSAN forms self-aggregated NANOTUBES, acts carrier.
• NANOTUBES loaded with FITC used to destroy ANGIOGENIC
tissue/blood vessels surrounding the tumour tissue.
• NANOMATERIAL targets infected macrophages in chronic
disease
• Achieve therapeutic drug concentration in vacuole of
infected macrophages ,reduce side effects and release
pro-inflammatory cytokines

9. • Macrophages multitude INFLAMATORY MEDITORS to
regulate inflammation.
• NANOPARTICLES targets the MACROPHANGE and resist
inflammation.
• NANOSYSTEMS could be useful in targeting macrophage
infections in chronic disease
• NANO-carrier mediated delivery of macrophage toxins is a
powerful approach in getting rid of unwanted
macrophages in gene THERAPHY.

10. • Cell adhesion molecules is divided into four classes
INTEGRINS
CADHERINS
SELECTINS
IMMUNOGLOBULINS
• These molecules are required for migration of
inflammatory cells.
• Excessive migration of NEUTROPHILS in inflamed lungs
leads to tissue damage and mortality.
• To avoid this NANOPARTICLES targets the inflammatory
molecules and destructs.

11. • NANOSYSTEM increases efficiency of drug delivery.
• It appears that NANO drug delivery systems hold great
potential to overcome some of the barriers to efficient
targeting of cells and molecules in inflammation and
cancer.
• It facilitates movement of drug across the barriers.
• Drugs are delivered to the targeted tissues to prevent the
effects on healthy tissues.
• The future remains exciting and wide open with
innovations in the field of nanotechnology.