Recent advances in nanotherapeutics from aissms college of pharmacy
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Nanotechnology is a dynamic and multi-disciplinary field here is the well explained PPT by Ashwini Sonawane from AISSMS College Of Pharmacy which is best pharmacy college in Pune.
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This document discusses nanoparticles for drug delivery. It begins with an introduction to nanoparticles and drug delivery. It then discusses the types of nanoparticles used for drug delivery, including gold nanoparticles and mesoporous silica nanoparticles. The advantages of using nanoparticles for drug delivery are that they have a high surface area to volume ratio, can target cells effectively, and allow controlled release of drugs with reduced side effects. The document outlines the process of targeted drug delivery using nanoparticles and developing targeted nanoparticles. It discusses applications in cancer therapy and diagnostics. In conclusions, nanoparticle drug delivery holds potential but challenges remain in targeting specific cells.
NANO PARTICLES FOR DRUG DELIVERY.pptx
This document discusses nanoparticles for drug delivery. It begins with an introduction to nanoparticles and drug delivery. It then discusses the types of nanoparticles used for drug delivery, including gold nanoparticles and mesoporous silica nanoparticles. The advantages of using nanoparticles for drug delivery are that they have a high surface area, can target cells, absorb and diffuse drugs well while reducing toxicity and side effects. The document outlines the components, process, and applications of nanoparticle drug delivery systems, including for cancer therapy and diagnostics. It concludes that nanoparticle drug delivery holds potential but challenges remain in precisely targeting molecules to avoid effects on healthy tissues.
Nanoscale drug delivery system
This document discusses nanoscale drug delivery systems for targeted cancer treatment. It describes how nano particles can be used to deliver drugs specifically to tumor sites to improve bioavailability and reduce toxicity. Common nanoscale delivery vehicles like liposomes, nanoparticles, and microemulsions are explained. The goals and advantages of these systems for targeted drug delivery, constant release kinetics, and improved stability are outlined. Barriers to conventional drug delivery and factors influencing delivery profiles are also reviewed. Magnetic hyperthermia for cancer using iron oxide nanoparticles is presented as a promising non-invasive treatment approach. Further refinement of reproducibility and reducing toxicity is still needed for these emerging nanotechnologies to fully realize their potential for chemotherapy.
Use of nanotechnology in medical science (pros and cons)
here in this presentation I had shared the basic information regarding use of nanotechnology in medical science and what wonders and improvements that nano technology did in the field of medical science.
Nanoparticles in cancer diagnosis
This document discusses the use of nanotechnology for cancer diagnosis and therapy. It begins by defining cancer and tumors, and then introduces nanotechnology and its applications in medicine including drug delivery, imaging, and cancer treatment. Specific nanoparticles discussed for cancer diagnosis include gold nanoparticles, bismuth sulfide nanoparticles, and iron oxide nanoparticles which can be used for computed tomography, magnetic resonance imaging, and ultrasound imaging, respectively. The document also discusses various nanoparticle-based approaches for detecting different types of cancer like bladder and breast cancer. In general, the document outlines how nanotechnology enables more precise cancer diagnosis and targeted therapy.
Nanoparticle use in pharmaceutical analysis
Nanoparticles between 1-100 nanometers in size are widely used in pharmaceutical analysis. They are used in (1) electrochemical analysis by constructing sensors and enhancing electron transfer, (2) clinical analysis by targeting biomarkers and improving detection sensitivity, and (3) separation analysis by acting as separation agents. Nanoparticles are also used to (4) enhance laser induced breakdown spectroscopy by lowering the breakdown threshold. They have various other applications including diagnostics, targeted drug delivery, and as biosensors and biolabels.
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Recent advances in nanotherapeutics from aissms college of pharmacy
- 2. Recent advances in Nanotherapeutics Presented by: Ashwini Sonawane M Pharm (SY- Pharmaceutics) Guided by: Dr. Monica RP Rao Department of Pharmaceutics AISSMS COLLEGE OF PHARMACY
- 3. Introduction • Nanotechnology is a dynamic and multi-disciplinary field • Profound impact on drug delivery, diagnostics, nutraceuticals • Tiny particles 5-200 nanometers (nm) • Site specific and targeted drug delivery
- 4. Types of nanostructures • Self assembled : Liposomes , polymeric micelles • Superparamagnetic nanostructures • Gold nanoparticles • Solid lipid nanoparticles • Polymeric nanoparticles • Aptamers • Quantum dots
- 6. Liposomes • Artificially constructed vesicles consisting of the phospholipid bilayer. • Ability to trap both hydrophobic and hydrophilic compounds. • Liposomal encapsulation of drug and protein shows improved drug efficacy. • E.g. Rifampicin and protein to improve antimicrobial efficiency. • Applications: cardiovascular & neurodegenerative diseases, diabetes, cancer. • Many applications in pulmonary drug delivery system.
- 7. Polymeric micelles • Amphiphilic molecules or copolymers. • Organized core structure in aqueous media above Critical Micelle Concentration. • Ability to entrap hydrophobic drugs • Achieve site-specific delivery and enhance their bioavailability. • Promising drug delivery platform for ocular diseases of posterior segments. • Age-related macular degeneration, diabetic retinopathy, and glaucoma. • Applications in gene delivery and diagnostic imaging.
- 8. Superparamagnetic nanoparticles • Superparamagnetic iron oxide nanoparticles (SPIONs) consisting of iron oxide core with paramagnetic properties • Guided to target area within our body through external magnets. • Applications from diagnosis to advanced cancer therapy, magnetic fluid hyperthermia, magnetic drug targeting, and theranostics. • Some of the toxicological aspects associated with SPIONs are • Protein aggregation due to iron accumulation, • Oxidative stress, • Altered cellular responses.
- 9. Gold nanoparticles • Gold core which is typically surrounded by organic monolayer. • Nanostructures such as nanoshells, nanorods, and nanocages • Used for photo thermal ablation of cancer cells with near-infrared light without damaging normal human tissues. • Multifunctional coated gold nanoshells used for examination of head and neck cancers. • Antioxidant properties • Promising candidates for skin immunization and transdermal delivery system.
- 10. Aptamers • Well-defined, folded, three dimensional structures. • Small single-stranded nucleic acids. • Intracellular, extracellular and cell surface targeting. • Mucin1 (MUC1) aptamer-Dox conjugates for lung cancer targeting • Prostate specific membrane antigen (PSMA) aptamer-doxorubicin conjugates for prostate cancer targeting.
- 11. Quantum dots • Fluorescent, inorganic, semiconductor nanoparticles • Diameter 2-10 nm. • Carbon dots or C-dots emerging as versatile nanomaterials. • Used to image cancer cells due to superior fluorescent properties. • Chitosan encapsulated zinc oxide quantum dots formulated for tumor targeting.
- 12. FDA approved nanomedicine Technology Formulation Name of the Product Company Approval year Liposome Vincristine Marqibo® Onco TCS 2012 Polymeric Micelles Estradiol Protein NPs. Estrasorb™ Novavax 2003 SPION Dextran Feridex®/ Endoderm® Endoderm® AMAG 2008 Gold Nanoparticles Silica nanoparticle with gold shell AuroShell® Nanospectra Bioscience 2012