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Vaccines: A Powerful and
Cost-Effective Tool Protecting
Americans Against Disease
2
CONFIDENTIAL
Vaccines have a successful history in eliminating or
significantly decreasing the incidence of dangerous
diseases
3
CONFIDENTIAL
Vaccines prime your
immune system to
recognize and
combat infections
Different vaccines offer varying types of
protection depending on the disease
Vaccines work by teaching
your body to recognize specific
dangerous pathogens, so your
immune system is prepared to
fight off that infection.
U.S. CDC. Explaining How Vaccines Work. https://www.cdc.gov/vaccines/hcp/conversations/understanding-vacc-work.html
U.S. NIH. How Does the Immune System Work? https://www.ncbi.nlm.nih.gov/books/NBK279364/
U.S. CDC. Explaining How Vaccines Work. https://www.cdc.gov/vaccines/hcp/conversations/understanding-vacc-work.html
Total Immunity
Target germs and
microbes that do
not change their
structure often
Protection against
Severe Disease
Target germs and
microbes that constantly
change their structure
Therapeutic
Vaccines
Train the immune
system to fight a
disease your body
already has
4
CONFIDENTIAL
Vaccines decrease the severity and impact of some diseases
COVID-19 Flu Whooping Cough
(Pertussis)
COVID-19 vaccines
prevented more than
18 million
hospitalizations
and nearly 3 million
deaths in the first
two years they were
available.
Flu vaccination prevented an
estimated 7.5 million
influenza cases, 3.7 million
medical visits, 105,000
hospitalizations and 6,300
deaths, between 2019-2020 –
the last flu season prior to the
COVID-19 pandemic.
The vaccine for
whooping cough is
effective in reducing
severity of a disease
that previously killed
1 in 10 children who
became infected prior
to the availability of
the vaccine.
https://www.commonwealthfund.org/blog/2022/two-years-covid-vaccines-prevented-millions-deaths-hospitalizations
https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626586/#:~:text=Both%20whole%2Dcell%20and%20acellular,in%20outbreaks%20in%20vaccinated%20cohorts.
https://www.gavi.org/vaccineswork/routine-vaccines/routine-vaccines-extraordinary-impact-pertussis
5
CONFIDENTIAL
Vaccines promote healthy aging
Timely vaccination could
help save these lives.
Vaccines promote healthy aging among the 50+ population, which is a major contributor to
our nation’s productivity, economic resilience and GDP growth.
https://www.medscape.com/viewarticle/886087
https://www.cdc.gov/vaccines/hcp/adults/for-patients/health-conditions.html
https://www.aarp.org/politics-society/advocacy/info-2019/older-americans-economic-impact-growth.html
50+ Population Contributions to U.S. GDP Growth
Vaccine preventable diseases like
influenza and shingles can lead to
increased risk of other conditions
and comorbidities in older adults,
such as cardiovascular and
neurovascular complications.
$0 $5 $10 $15 $20
U.S
GDP (in trillions)
China
U.S. 50+
Population
Japan
Germany
U.K.
$20.5
$13.4
$8.3
$5.0
$4.0
$2.8
6
CONFIDENTIAL
https://www.commonwealthfund.org/blog/2022/two-years-covid-vaccines-prevented-millions-deaths-hospitalizations
https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626586/#:~:text=Both%20whole%2Dcell%20and%20acellular,in%20outbreaks%20in%20vaccinated%20cohorts.
https://www.gavi.org/vaccineswork/routine-vaccines/routine-vaccines-extraordinary-impact-pertussis
Vaccines undergo extensive testing and monitoring to help ensure
safety and efficacy
Vaccines undergo
rigorous R&D, including
large clinical trials which
include thousands of
patient volunteers.
This work builds on a
foundation of ongoing
research and innovation
that can take decades.
Like all medicines, vaccines must
undergo an intensive review
process by the U.S. Food and
Drug Administration (FDA) to
ensure safety and efficacy.
The FDA also inspects the
manufacturing of the vaccine
candidate and evaluates its
potency, safety and purity.
After approval,
biopharmaceutical
companies, the FDA,
and the CDC
continue monitoring
product safety
through various
means.
The CDC’s Advisory
Committee on
Immunization Practices
(ACIP) develops
recommendations for
who should receive
immunizations and on
what schedule.
Research &
Development
Regulatory
Review
Immunization
Recommendations
Ongoing Safety
Monitoring
7
CONFIDENTIAL
Developing a new
vaccine is a lengthy,
challenging and
expensive process,
largely driven by the
biopharmaceutical
industry
New vaccine development
requires large-scale clinical
trials, and total development
costs that can exceed
$1 billion.
https://www.hhs.gov/sites/default/files/HHS-Vaccines-Report.pdf
U.S. Department of Health and Human Services. 2021. Vaccines
National Strategic Plan 2021–2025. Washington, DC
Research
Academia
Government
Industry
Development
of a New
Vaccine
Capabilities
Expertise
Complex
Manufacturing
Partners
8
CONFIDENTIAL
The U.S. leads the world in developing innovative vaccine technology
https://www.researchamerica.org/wp-content/uploads/2022/09/ResearchAmerica-Investment-Report.Final_.January-2022-1.pdf
https://info.evaluate.com/rs/607-YGS-364/images/2022%20World%20Preview%20Report.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151793/
The U.S. biopharmaceutical industry
alone accounts for
more than half
of global biopharmaceutical R&D spending
Over the past 20 years,
most new vaccines approved worldwide
have been developed in the
United States
9
CONFIDENTIAL
U.S. leadership in vaccine innovation benefits Americans in
several ways
The biopharmaceutical industry's years of research and investments in vaccine
technologies yields a range of benefits
Health benefits Security benefits Health system
Life-saving vaccines for
children and adults
16 diseases are now preventable
in the U.S. due to the development
and availability of childhood
vaccines, and the introduction of a
new shingles vaccine in 2017 has
reduced the risk of shingles
among older adults by 90%.
The ability to develop vaccines
quickly and without relying on other
countries makes America more secure
The U.S was able to mobilize quickly
to respond to the COVID-19 pandemic with
a safe and effective vaccine in record time,
saving millions from severe illness
and death and well over billions in avoidable
health care costs.
Vaccine preventable
diseases, and conditions
like flu, pneumococcal
disease, shingles and
whooping cough, cost
$27 billion in direct and
indirect costs each year
among adults over the age
of 50.
https://phrma.org/-/media/Project/PhRMA/PhRMA-Org/PhRMA-Org/PDF/medicines-in-development-for-vaccines-2020.pdf
https://www.who.int/news-room/fact-sheets/detail/measles
https://www.cdc.gov/vaccines/events/niiw/overview.html
https://www.cdc.gov/vaccines/vpd/shingles/public/shingrix/index.html#:~:text=In%20adults%2050%20to%2069,%2C%20Shingrix%20was%2089%25%20effective.
Meagan C. Fitzpatrick et al., “Two Years of U.S. COVID-19 Vaccines Have Prevented Millions of Hospitalizations and Deaths,” To the Point (blog), Commonwealth Fund, Dec. 13, 2022. https://doi.org/10.26099/whsf-fp90
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00140-7/fulltext
https://www.who.int/news-room/fact-sheets/detail/ageing-and-health
10
CONFIDENTIAL
Childhood vaccines produce significant savings
Each dollar invested in pediatric immunization alone results in $7.50 in savings for
health systems and society
https://www.rtihs.org/updates-and-events/impact-routine-childhood-immunization
https://www.cdc.gov/vaccines/programs/vfc/protecting-children.html
Childhood vaccines
prevented more than
one million
early deaths and
saved nearly
$2.2 trillion
between 1994–2021
$63.0
$8.5
$0.0
$10.0
$20.0
$30.0
$40.0
$50.0
$60.0
$70.0
Without childhood immunization With childhood immunization
Estimated Economic Cost of Vaccine Preventable Diseases
in the U.S. Among Children Born in 2017
Total
costs,
billions
U.S.
$
11
CONFIDENTIAL
Vaccine preventable diseases cost the U.S. billions of dollars each
year
Ozawa S, Portnoy A, et al. “Modeling The Economic Burden Of Adult Vaccine-Preventable Diseases In The United States, 2016.” Health Affairs 35, No. 11 (2016): 2124-2132.
https://www.healthaffairs.org/doi/pdf/10.1377/hlthaff.2016.0462
Rose, Adam. “COVID-19 economic impacts in perspective: A comparison to recent U.S. disasters, 2021.” International Journal of Disaster Risk Reduction, 2021; Volume 60, 15 June 2021, 102317.
https://www.sciencedirect.com/science/article/pii/S2212420921002831?via%3Dihub
$0 $2 $4 $6 $8
$540 Million
$782 Million
$1.9 Billion
$5.8 Billion
All other VPDs
(incl. Hepatitis, MMR,
Tetanus & Pertussis)
Herpes
zoster
Pneumococcal
disease
Flu
Annual Costs Associated with Major Vaccine Preventable
Diseases
U.S. Dollars
The COVID-19
pandemic’s
total economic
impacts in the U.S.
are estimated to be
$6.12 trillion,
twice as great as
those of the Great
Recession of 2008
12
CONFIDENTIAL
Recent Successes
As we continue to expand our understanding of science, the future
of vaccine development is more promising than ever
To deliver on the promise of this ongoing research, it is vital that the
biopharmaceutical policy environment supports advancements in science and
recognizes the role of vaccines in improving public health and enabling future
pandemic preparedness.
Pipeline Promises
https://phrma.org/-/media/Project/PhRMA/PhRMA-Org/PhRMA-Org/PDF/medicines-in-development-for-vaccines-2020.pdf
Resounding success from
decades of research
resulting in new vaccines
for deadly diseases,
including recent
advances for shingles,
COVID-19, chikungunya
virus and RSV
Hundreds of vaccines are currently in
development
to help prevent and fight disease across a
range of conditions from HIV, cancers, malaria
and more.
Supporting
Future Vaccines
13
CONFIDENTIAL
As a result, almost 50 million
Part D-enrolled beneficiaries will
now have access to these
vaccines without cost sharing.
Policymakers can support and protect advances in vaccines
Policymakers should ensure promising new vaccines and
vaccine technology receive appropriate coverage by:
Reauthorizing critical provisions in the Pandemic and All Hazards Preparedness Act;
Protecting intellectual property to defend American biopharmaceutical research,
development, manufacturing and collaboration; and
Rejecting policies that would undermine intellectual property protections.
https://avalere.com/insights/several-changes-to-adult-vaccine-access-enacted-through-ira
https://www.cms.gov/data-research/statistics-trends-and-reports/medicare-advantagepart-d-contract-and-enrollment-data
PhRMA supports the policy that
eliminated vaccine cost sharing in
Medicare Part D for all ACIP-
recommended adult vaccines starting
January 1, 2023.
Present policy... ...leads to future protection

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PhRMA Vaccines Deck_05-15_2024_FINAL.pptx

  • 1. Spring 2024 Vaccines: A Powerful and Cost-Effective Tool Protecting Americans Against Disease
  • 2. 2 CONFIDENTIAL Vaccines have a successful history in eliminating or significantly decreasing the incidence of dangerous diseases
  • 3. 3 CONFIDENTIAL Vaccines prime your immune system to recognize and combat infections Different vaccines offer varying types of protection depending on the disease Vaccines work by teaching your body to recognize specific dangerous pathogens, so your immune system is prepared to fight off that infection. U.S. CDC. Explaining How Vaccines Work. https://www.cdc.gov/vaccines/hcp/conversations/understanding-vacc-work.html U.S. NIH. How Does the Immune System Work? https://www.ncbi.nlm.nih.gov/books/NBK279364/ U.S. CDC. Explaining How Vaccines Work. https://www.cdc.gov/vaccines/hcp/conversations/understanding-vacc-work.html Total Immunity Target germs and microbes that do not change their structure often Protection against Severe Disease Target germs and microbes that constantly change their structure Therapeutic Vaccines Train the immune system to fight a disease your body already has
  • 4. 4 CONFIDENTIAL Vaccines decrease the severity and impact of some diseases COVID-19 Flu Whooping Cough (Pertussis) COVID-19 vaccines prevented more than 18 million hospitalizations and nearly 3 million deaths in the first two years they were available. Flu vaccination prevented an estimated 7.5 million influenza cases, 3.7 million medical visits, 105,000 hospitalizations and 6,300 deaths, between 2019-2020 – the last flu season prior to the COVID-19 pandemic. The vaccine for whooping cough is effective in reducing severity of a disease that previously killed 1 in 10 children who became infected prior to the availability of the vaccine. https://www.commonwealthfund.org/blog/2022/two-years-covid-vaccines-prevented-millions-deaths-hospitalizations https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626586/#:~:text=Both%20whole%2Dcell%20and%20acellular,in%20outbreaks%20in%20vaccinated%20cohorts. https://www.gavi.org/vaccineswork/routine-vaccines/routine-vaccines-extraordinary-impact-pertussis
  • 5. 5 CONFIDENTIAL Vaccines promote healthy aging Timely vaccination could help save these lives. Vaccines promote healthy aging among the 50+ population, which is a major contributor to our nation’s productivity, economic resilience and GDP growth. https://www.medscape.com/viewarticle/886087 https://www.cdc.gov/vaccines/hcp/adults/for-patients/health-conditions.html https://www.aarp.org/politics-society/advocacy/info-2019/older-americans-economic-impact-growth.html 50+ Population Contributions to U.S. GDP Growth Vaccine preventable diseases like influenza and shingles can lead to increased risk of other conditions and comorbidities in older adults, such as cardiovascular and neurovascular complications. $0 $5 $10 $15 $20 U.S GDP (in trillions) China U.S. 50+ Population Japan Germany U.K. $20.5 $13.4 $8.3 $5.0 $4.0 $2.8
  • 6. 6 CONFIDENTIAL https://www.commonwealthfund.org/blog/2022/two-years-covid-vaccines-prevented-millions-deaths-hospitalizations https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626586/#:~:text=Both%20whole%2Dcell%20and%20acellular,in%20outbreaks%20in%20vaccinated%20cohorts. https://www.gavi.org/vaccineswork/routine-vaccines/routine-vaccines-extraordinary-impact-pertussis Vaccines undergo extensive testing and monitoring to help ensure safety and efficacy Vaccines undergo rigorous R&D, including large clinical trials which include thousands of patient volunteers. This work builds on a foundation of ongoing research and innovation that can take decades. Like all medicines, vaccines must undergo an intensive review process by the U.S. Food and Drug Administration (FDA) to ensure safety and efficacy. The FDA also inspects the manufacturing of the vaccine candidate and evaluates its potency, safety and purity. After approval, biopharmaceutical companies, the FDA, and the CDC continue monitoring product safety through various means. The CDC’s Advisory Committee on Immunization Practices (ACIP) develops recommendations for who should receive immunizations and on what schedule. Research & Development Regulatory Review Immunization Recommendations Ongoing Safety Monitoring
  • 7. 7 CONFIDENTIAL Developing a new vaccine is a lengthy, challenging and expensive process, largely driven by the biopharmaceutical industry New vaccine development requires large-scale clinical trials, and total development costs that can exceed $1 billion. https://www.hhs.gov/sites/default/files/HHS-Vaccines-Report.pdf U.S. Department of Health and Human Services. 2021. Vaccines National Strategic Plan 2021–2025. Washington, DC Research Academia Government Industry Development of a New Vaccine Capabilities Expertise Complex Manufacturing Partners
  • 8. 8 CONFIDENTIAL The U.S. leads the world in developing innovative vaccine technology https://www.researchamerica.org/wp-content/uploads/2022/09/ResearchAmerica-Investment-Report.Final_.January-2022-1.pdf https://info.evaluate.com/rs/607-YGS-364/images/2022%20World%20Preview%20Report.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151793/ The U.S. biopharmaceutical industry alone accounts for more than half of global biopharmaceutical R&D spending Over the past 20 years, most new vaccines approved worldwide have been developed in the United States
  • 9. 9 CONFIDENTIAL U.S. leadership in vaccine innovation benefits Americans in several ways The biopharmaceutical industry's years of research and investments in vaccine technologies yields a range of benefits Health benefits Security benefits Health system Life-saving vaccines for children and adults 16 diseases are now preventable in the U.S. due to the development and availability of childhood vaccines, and the introduction of a new shingles vaccine in 2017 has reduced the risk of shingles among older adults by 90%. The ability to develop vaccines quickly and without relying on other countries makes America more secure The U.S was able to mobilize quickly to respond to the COVID-19 pandemic with a safe and effective vaccine in record time, saving millions from severe illness and death and well over billions in avoidable health care costs. Vaccine preventable diseases, and conditions like flu, pneumococcal disease, shingles and whooping cough, cost $27 billion in direct and indirect costs each year among adults over the age of 50. https://phrma.org/-/media/Project/PhRMA/PhRMA-Org/PhRMA-Org/PDF/medicines-in-development-for-vaccines-2020.pdf https://www.who.int/news-room/fact-sheets/detail/measles https://www.cdc.gov/vaccines/events/niiw/overview.html https://www.cdc.gov/vaccines/vpd/shingles/public/shingrix/index.html#:~:text=In%20adults%2050%20to%2069,%2C%20Shingrix%20was%2089%25%20effective. Meagan C. Fitzpatrick et al., “Two Years of U.S. COVID-19 Vaccines Have Prevented Millions of Hospitalizations and Deaths,” To the Point (blog), Commonwealth Fund, Dec. 13, 2022. https://doi.org/10.26099/whsf-fp90 https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00140-7/fulltext https://www.who.int/news-room/fact-sheets/detail/ageing-and-health
  • 10. 10 CONFIDENTIAL Childhood vaccines produce significant savings Each dollar invested in pediatric immunization alone results in $7.50 in savings for health systems and society https://www.rtihs.org/updates-and-events/impact-routine-childhood-immunization https://www.cdc.gov/vaccines/programs/vfc/protecting-children.html Childhood vaccines prevented more than one million early deaths and saved nearly $2.2 trillion between 1994–2021 $63.0 $8.5 $0.0 $10.0 $20.0 $30.0 $40.0 $50.0 $60.0 $70.0 Without childhood immunization With childhood immunization Estimated Economic Cost of Vaccine Preventable Diseases in the U.S. Among Children Born in 2017 Total costs, billions U.S. $
  • 11. 11 CONFIDENTIAL Vaccine preventable diseases cost the U.S. billions of dollars each year Ozawa S, Portnoy A, et al. “Modeling The Economic Burden Of Adult Vaccine-Preventable Diseases In The United States, 2016.” Health Affairs 35, No. 11 (2016): 2124-2132. https://www.healthaffairs.org/doi/pdf/10.1377/hlthaff.2016.0462 Rose, Adam. “COVID-19 economic impacts in perspective: A comparison to recent U.S. disasters, 2021.” International Journal of Disaster Risk Reduction, 2021; Volume 60, 15 June 2021, 102317. https://www.sciencedirect.com/science/article/pii/S2212420921002831?via%3Dihub $0 $2 $4 $6 $8 $540 Million $782 Million $1.9 Billion $5.8 Billion All other VPDs (incl. Hepatitis, MMR, Tetanus & Pertussis) Herpes zoster Pneumococcal disease Flu Annual Costs Associated with Major Vaccine Preventable Diseases U.S. Dollars The COVID-19 pandemic’s total economic impacts in the U.S. are estimated to be $6.12 trillion, twice as great as those of the Great Recession of 2008
  • 12. 12 CONFIDENTIAL Recent Successes As we continue to expand our understanding of science, the future of vaccine development is more promising than ever To deliver on the promise of this ongoing research, it is vital that the biopharmaceutical policy environment supports advancements in science and recognizes the role of vaccines in improving public health and enabling future pandemic preparedness. Pipeline Promises https://phrma.org/-/media/Project/PhRMA/PhRMA-Org/PhRMA-Org/PDF/medicines-in-development-for-vaccines-2020.pdf Resounding success from decades of research resulting in new vaccines for deadly diseases, including recent advances for shingles, COVID-19, chikungunya virus and RSV Hundreds of vaccines are currently in development to help prevent and fight disease across a range of conditions from HIV, cancers, malaria and more. Supporting Future Vaccines
  • 13. 13 CONFIDENTIAL As a result, almost 50 million Part D-enrolled beneficiaries will now have access to these vaccines without cost sharing. Policymakers can support and protect advances in vaccines Policymakers should ensure promising new vaccines and vaccine technology receive appropriate coverage by: Reauthorizing critical provisions in the Pandemic and All Hazards Preparedness Act; Protecting intellectual property to defend American biopharmaceutical research, development, manufacturing and collaboration; and Rejecting policies that would undermine intellectual property protections. https://avalere.com/insights/several-changes-to-adult-vaccine-access-enacted-through-ira https://www.cms.gov/data-research/statistics-trends-and-reports/medicare-advantagepart-d-contract-and-enrollment-data PhRMA supports the policy that eliminated vaccine cost sharing in Medicare Part D for all ACIP- recommended adult vaccines starting January 1, 2023. Present policy... ...leads to future protection

Editor's Notes

  1. GS