This document discusses evidence-based practice in nursing and common myths versus realities. It outlines that evidence-based practice integrates the best research evidence with clinical expertise and patient values. The 5 A steps for evidence-based practice are presented as ask, access, appraise, apply, and assess. Myths about evidence-based practice include thinking a claim that a practice is evidence-based makes it true, or that all evidence is equal. Realities include the need to critically appraise evidence and implement practices on a small scale first. Evidence-based practice requires partnerships across disciplines and stakeholders to be successful.