This document discusses the causes, clinical assessment, investigations, and management of persistent neonatal jaundice in babies over 2 weeks old. Key causes discussed include breast milk jaundice, infections like UTIs, and hemolytic anemias. Clinical assessment involves history, examination of vital signs and jaundice severity, and urine/stool examination. Investigations include blood tests to check bilirubin levels and identify underlying causes. Imaging like ultrasound and HIDA scans can identify conditions like biliary atresia. The document emphasizes the importance of early diagnosis and management of conditions like biliary atresia to improve prognosis.