This document discusses different types of mutations including point mutations, insertions, deletions, and frameshift mutations. It provides examples of each type of mutation and describes how they can change DNA and cause diseases. Specifically, it discusses how point mutations can cause cystic fibrosis and sickle cell anemia by changing single nucleotides in genes. It also explains how frameshift mutations can result in truncated nonfunctional proteins and discusses how they have been linked to diseases like Crohn's disease and some cancers.
regulation of gene expression in eukaryotes is a complex mechanism involved many factors. out of many levels of regulations, chromosomal and transcription level of regulation are discussed in this slides.
regulation of gene expression in eukaryotes is a complex mechanism involved many factors. out of many levels of regulations, chromosomal and transcription level of regulation are discussed in this slides.
Dna methylation ppt
definition of Dna methylation ppt
discovery of Dna methylation ppt
types of Dna methylation ppt
history of Dna methylation ppt
process of Dna methylation ppt
mechanism of Dna methylation ppt
methylation in cancer
cytosine methylation
genomic imprinting
N-terminal tails of histones are the most accessible regions for modifications. These post-translational modification (PTM) of histones is a crucial step in epigenetic regulation of a gene.
Introduction
What is Protein Sequencing?
History
Determination of amino acid composition
Sequencing methods
N terminal sequencing
C terminal sequencing
Mass spectrometer
Application
Reference
Dna methylation ppt
definition of Dna methylation ppt
discovery of Dna methylation ppt
types of Dna methylation ppt
history of Dna methylation ppt
process of Dna methylation ppt
mechanism of Dna methylation ppt
methylation in cancer
cytosine methylation
genomic imprinting
N-terminal tails of histones are the most accessible regions for modifications. These post-translational modification (PTM) of histones is a crucial step in epigenetic regulation of a gene.
Introduction
What is Protein Sequencing?
History
Determination of amino acid composition
Sequencing methods
N terminal sequencing
C terminal sequencing
Mass spectrometer
Application
Reference
Cell Biology and genetics paper - Mutation a basic touch to b.sc students with examples. DNA, genome, gene level mutation and chromosome level with examples. Touched some of the mutation types.
Mutation Repair and DNA Replication.pptxhamzalatif40
In this Presentation Chapter 7 & 8 from the book Advanced Molecular Biology are discussed. Focus has been given to the mutation, its types, mutation repair, Different Repairing mechanisms and DNA Replication is explained with details.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
2. Types of mutations
lPoint Mutation:
üA point mutation is a type of mutation in
DNA or RNA, the cell’s genetic material, in
which one single nucleotide base is added,
deleted or changed. DNA and RNA are made
up of many nucleotides. There are five
different molecules that can make up
nitrogenous bases on nucleotides: cytosine,
guanine, adenine, thymine (in DNA) and
uracil (in RNA), abbreviated C, G, A, T, and U.
3. Types of mutations
lPoint Mutation:
üThe specific sequence of nucleotides
encodes all the information for carrying
out all cell processes. In general, a
mutation is when a gene is altered
through a change in DNA structure; this
may refer even to entire sections of
chromosomes. A point mutation is
specifically when only one nucleotide
4. lSubstitution:
üA substitution is a mutation that exchanges
one base for another
lSuch a substitution could:
1.Change a codon to one that encodes a
different amino acid and cause a small change
in the protein produced.For example, sickle
cell anemia is caused by a substitution in the
beta-hemoglobin gene, which alters a single
amino acid in the protein produced.
Types of point mutations
5. Types of point mutations
u2.change a codon to one that encodes
the same amino acid and causes no
change in the protein produced. These are
called silent mutations.
u3.change an amino-acid-coding codon to
a single "stop" codon and cause an
incomplete protein. This can have serious
effects since the incomplete protein
probably won't function.
7. Types of mutations
lFrameshift:
üSince protein-coding DNA is divided
into codons three bases long, insertions
and deletions can alter a gene so that its
message is no longer correctly parsed.
These changes are called frameshifts.
üFor example, consider the sentence, "The
fat cat sat." Each word represents a
codon. If we delete the first letter and
8. Types of mutations
üIn frameshifts, a similar error occurs at
the DNA level, causing the codons to
be parsed incorrectly. This usually
generates truncated proteins that are
as useless as "hef atc ats at" is
uninformative.There are other types of
mutations as well, but this short list
should give you an idea of the
possibilities.
9. lInsertion:
ü Insertions are mutations in which extra
base pairs are inserted into a new place
in the DNA.
uEx:
Types of frameshift
mutations
11. üCystic Fibrosis:
• Cystic Fibrosis (CF) is a recessive inherited
disorder most common among people of
European descent. In the United States, 1 in
3500 newborns are born with cystic fibrosis,
and 1 in 30 Caucasian Americans is a carrier.
There are many different mutations that can
cause CF, but the most common one is a
deletion of three nucleotides in the cystic
fibrosis transmembrane conductance
regulator (CFTR) gene that results in the loss
Diseases Caused by Point
Mutations
12. Diseases Caused by Point
Mutations
üCystic Fibrosis:
• CF is associated with thick, sticky mucus
in the lungs and trouble breathing, salty
sweat, infertility in certain individuals,
and a shortened life expectancy (about
42-50 years in developed countries).
13. Diseases Caused by Point Mutations
üSickle-Cell Anemia:
• Sickle-cell anemia is a recessive disorder
caused by a single substitution in the gene that
creates hemoglobin, which carries oxygen in
the blood. Normally, glutamic acid is produced
in the chain, but the substitution causes valine
to be produced at that spot instead. When
people have two copies of this mutation, it
results in thin sickle-shaped blood cells that
sometimes cannot carry oxygen properly.
14. Diseases Caused by Point
Mutations
üSickle-Cell Anemia:
• About 80% of people with sickle-cell disease
are in sub-Saharan Africa, where being a
carrier for sickle-cell anemia (having only one
copy of the gene, not two) actually helps
protect against malaria. It is also found in
other parts of the world such as India and the
Middle East, and affects about 1 in 500
African Americans. Symptoms include
anemia, obstruction of blood vessels, and
15. Diseases caused by frameshift
mutation
üDiseases caused by frameshift
mutations in genes include Crohn’s
disease, cystic fibrosis, and some
forms of cancer.
ü On the other hand, when some
proteins become dysfunctional, they
could have a protective effect, as
seen in the resistance to HIV in