Define mutation. Develop the understanding of causes of mutation, different types of mutation, effects of mutation and prevention of mutation. Guided by – Prof. K. M. Shamim

1. Mutation
Dr. Rayhan Shahrear
MS Resident (Phase A, Year 1, Block 2)
Department of Anatomy, BSMMU
Guided by – Prof. K. M. Shamim

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3. 3

4. Mutation is
• a permanent change
• in base sequence
• of the genome
• of an organism
• or in extra-chromosomal genetic elements
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5. Causes of Mutation
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6. 6

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• Benzene
• Vinyl chloride
• Formaldehyde
• Dioxane
• Acrylamide
• Ethidium
bromide
• Formaldehyde
• Dioxane
• Nicotine
• Ethanol
• Mercury
compounds
• Lead compounds
• Phenol
• Carbon disulfide
• Toluene
• Xylene

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11. Types of Mutation
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GGTAGCGTGTTGA
T C A A C A C G
C
G C T A C C C A
G T
A
T T
A C
G G C A C
C G T GC
G A
T

13. Deletion and insertion
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14. Reciprocal translocation
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15. Robertsonian translocation
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16. Inversion
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18. Normal hemoglobin
ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT
Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr
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Sickle cell hemoglobin
ATG GTG CAC CTG ACT CCT GTG GAG AAG TCT GCC GTT ACT
Met Val His Leu Thr Pro Val Glu Lys Ser Ala Val Thr

19. D CN ASS H E H A O E F A T C A T
She has one fat catShe had ona cef atc atShe had one fat cat
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20. Impact of Mutation
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23. DMD
by deletion
in short arm
of X chromosome
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24. Down’s
syndrome
Translocation
of 21q
on 14
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29. Summary
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30. •Define mutation
•Develop the understanding of
• Causes of mutation
• Different types of mutation
• Effects of mutation
• Prevention of mutation
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32. Thank you
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