This presentation discusses moisture activated dry granulation technology (MADG). MADG is an advanced granulation technique that uses moisture to activate granule formulation but does not require heat drying. The presentation outlines the stages of MADG, including wet agglomeration where the powder blend is mixed with a small amount of water, and moisture absorption where moisture absorbents are added to redistribute moisture in the mixture and dry it. The presentation notes advantages of MADG such as short processing time and suitability for continuous processing, but also disadvantages such as difficulty developing formulations for moisture sensitive drugs or those with high drug loading.

1. Presentation on…
Moisture Activated Dry Granulation
Technology
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By-
Pratik Swarup Das
M.Pharm (pharmaceutics)
NIET, Greater Noida.

2. CONTENTS
Advanced Granulation Techniques
Moisture Activated Dry Granulation Technology
Advantages
Disadvantages
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3. Why advanced granulation techniques?
To overcome the limitations and difficulties associated
with-
dry granulation
wet granulation
direct compression
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4. Advanced Granulation Techniques
Steam Granulation
Melt Granulation
Moisture Activated Dry Granulation (MADG)
Moist Granulation Technique (MGT)
Thermal Adhesion Granulation Process (TAGP)
Foam Granulation
Pneumatic Dry Granulation (PDG)
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5. Freeze granulation Technology
Steam Granulation
Melt Extrusion Technology
Liquisolid Technique
TOPO Technology
Continuous Flow Technology
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6. MOISTURE ACTIVATED DRY GRANULATION (MADG)
As the name implies, this is a process where moisture is used to activate the
granule formulation, but the granules are not heat dried.
Moisture Activated Dry Granulation (MADG) was developed in response to
the difficulties experienced with wet granulation, in terms of endpoint, drying
and milling.
STAGES
WET
AGGLOMERATION
MOISTURE ABSORPTION
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7. In Agglomeration Stage---
 Drug is blended with diluents and agglomerating binders
to form uniform mixture
 A small amount of water (1-4%) is sprayed into the powder
blend
 Agglomerates are small and spherical (size 150–500μm)
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8. In moisture absorption stage---
 Moisture absorbents like microcrystalline cellulose or
silicon dioxide, are added while mixing.
 Moisture redistribution within the mixture.
 Entire mixture becomes relatively dry.
 Granulation with uniform particle-size distribution.
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9. Flow diagram of moisture activated dry granulation process
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10. Advantages:
1.Applicable to more than 90% of the granulation need for
pharmaceutical, food and nutritional industry.
2. Short processing time.
3. Suitable for continuous processing
4. Less energy involved during processing.
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11. Disadvantages:
 Moisture sensitive and high moisture absorbing API are
poor candidates.
 Formulations with high drug loading are difficult to
develop.
 Could be other issues with the API, with high-drug load
formulations being particularly difficult to develop.
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12. THANK
YOU….
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