1) Tablet manufacturing has advanced with new material handling, raw materials, granulation, coating, and compression technologies that improve efficiency and quality. 2) Advancements include direct compression excipients, dry and melt granulation methods, all-in-one systems, and single-step tablet coating and manufacturing processes. 3) New equipment allows for automated and continuous processing with improved control and monitoring from granulation to finished tablets.

1. BY
SAMEERA(M-PHARMACY)
PULLA REDDY INSTITUTE OF
PHARMACY

2. INTRODUCTION
 Tablets are oral solid dosage forms of
medicinal substances usually prepared with
the aid of suitable pharmaceutical adjuvants.
 Recent trends in tablet technology reduce
the manual input and performing the process
validation of each unit operation thus ensuring
enhance product quality and process
reliability.

3.  Advancement in the material Handling
Technology.
 Advancement in Raw Materials.
 Advancement in Granulation Technology.
 Advancement in Equipment Technology.

4.  Advancement in Compression Technology.
 Advancement in Tablet Coating Materials.
 Advancement in the Tablet Coating
Techniques.
 Advancement in Coating Equipment
Technology.

5. Advancement in the material Handling
Technology
 Disadvantages of Traditional manual handling of
the materials is expensive, unsafe , delay in
production & loss of material which ultimately
affects product output.
 Advancement in the material handling can be
explained by the case of MERCK SHARP & DOHME
CO. which employs 3 storey building and 3
operational columns.

6.  Material is transferred to the top by vacuum
transfer systems and it is allow to flow under gravity
through operational columns during which materials
are processed for various unit operations
 ELLI-LILLY & Co. utilizes drive less trains to convey
raw materials and vacuum powder transfer
mechanism

7. Advancement in Raw Materials
 Recent trends in technology direct the material science to
affect the flow properties & compressibility in order to
get a directly compressible vehicle or multiple use
excipients.
 So as to avoid multiple steps involved in the tablet
manufacturing & subsequently to have one or two step
technology. Ready to use co-processed blends for direct
compression are available. Ex;-Indipress
cellatose, Pharmatose DCL 40.

8.  Commercially available ready-to-use co-
processed blends are listed in the below table.
Tablet Excipients Trade Name Composition
Filler/disintegrant Avicel Microcrystalline
cellulose
Filler/disintegrant Elcema Micro fine cellulose
Filler/disintegrant Sta-Rx 1500 Directly compressible
starch
Filler/binder Dipac 97% sucrose + 3%
modified dextrins
Filler/binder Emdex/cellutab 90-92% dextrose + 3-5%
maltose

9. 1. Pneumatic Dry Granulation (PDG)
2. Freeze granulation Technology
3. Foamed Binder Technologies (FBT)
4. Melt Granulation Technology
5. Steam Granulation
6. Moisture Activated Dry Granulation (MADG)
7. Thermal Adhesion Granulation Process (TAGP)

10. 1. Pneumatic Dry Granulation (PDG)
A novel dry method for automatic or semi-
automatic production of granules .
 Pneumatic Dry Granulation Replaces Wet
Granulation to overcome the disadvantages of
Wet Granulation.

11.  Swedish Ceramic Institute (SCI) has adopted and
developed an alternative technique – freeze
granulation (FG).
 It enables preservation of the homogeneity from
suspension to dry granules.
 By spraying a powder suspension into liquid
nitrogen, the drops (granules) are instantaneously
frozen.

12.  As the name suggests we will use foam binders
such as METHOCEL polymers to improve binder
distribution in the formulation mix and yields a
remarkable array of processing advantages.
A simple foam generation apparatus is
used to incorporate air into a conventional
watersoluble polymeric excipients binder such
as METHOCEL hypromellose

13. 4. Melt Granulation Technology
 Principle of melt granulation:

14. Advancement in Equipment
Technology
 Semiautomatic or fully automatic
instrumentation system has been held in last
decade to optimize each unit operation from
granulation to compression.
 A. SPHERONIZERS
 B. MIXER-PROCESSOR &MIXER-GRANULATOR
 C. ALL-IN-ONE GRANULATION TECHNOLOGY

15. ADVANCEMENT IN
COMPRESSION TECHNOLOGY
 OSDrC® OPTIDOSE TM (One-Step Dry-Coating)
 Single-step manufacturing opens the door to a
host of new formulations
• An innovative first-of-its-kind manufacturing
process
• Newly developed rotary punch tableting machine
• Research and technical collaboration between
pharmaceutical manufacturer and tableting
machine manufacture

17. Outer layer forms sides and top
Active pharmaceutical
ingredients
form core
Outer layer forms
base

18. OSDrC® OPTIDOSETM
technology:
Broad Range of Tablet
Options:
● Bi-Layer Tablets
● Dividable Tablets
● IR/ER Combination Tablets
● Combination Products
(multiple API in single tablets)
● Direct Compression Orally
Disintegrating Tablets (ODT)
Pulsatile Release Tablets

19. Thomas Tablet Sentinel(TTS)
Thomas Tablet Sentinel(TTS)-2
Thomas Tablet Sentinel(TTS)-3
PH-800 Automated Tablet production
system

23. A. FLUID BED OR AIR SUSPENSION
COATING
B.COMPRESSION COATING
C. ELECTROSTATIC COATING
D. GELCAP (GELATIN COATED
CAPSULE SHAPED TABLETS)

24.  Dria-coater, Hi-coater and Accelacoater.
 The Glatt-coater (cap. 25-1000 kg) is
the latest perforated pan coater to be introduced
in the market.
 Auto coaters (Granscoater) are available with
software programmes and parameter setting
Profiles.
• NeoCota is the recent introduction of fully
automated sugar and film coating system of
tablets and pellets.

27. REFERENCES
 Remington.The science & practice of
pharmacy,21st edition, vol-1.
 Leon Lachman,Lieberman AH,Kanig JL,the theory
& practice of industrial pharmacy,4th edition.
 H.C.Ansel introduction to dosage forms.
 Michael E Aulton,Pharmaceutics science of dosage
form design.2nd edition.
 Pharmaceutical dosage froms ,Tablets vol-1-3.
 Internet