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CELL BIOLOGY




               1
2
3
Mitochondria The organelle that
releases energy in the cell. (The
powerhouse of the cell)
Only found in ANIMAL cells.
Mitochondria produce ATP using
energy stored in food molecules.
•   Mitochondria are the primary energy
    producers in cells.




                                          6
Structure

   Mitochondria have a double membrane
    structure

   There is a single outer membrane and a
    folded inner membrane




                                             7
   Sac with two inner compartments which
    are separated by the inner membrane.

   The first compartment is between the
    outer and inner membranes.

   The outer compartment is inside the
    inner membrane.

                                            8
   The outer mitochondrial membrane is
    composed of about 50% phospholipids
    by weight and contains a variety of
    enzymes involved in such diverse
    activities as the elongation of fatty acids,
    oxidation of epinephrine (adrenaline),
    and the degradation of tryptophan.




                                                   9
   The inner membrane contains proteins with
    three types of functions [Alberts, 1994]:
   those that carry out the oxidation reactions
    of the respiratory chain
   ATP synthase, which makes ATP in the
    matrix
   specific transport proteins that regulate the
    passage of metabolites into and out of the
    matrix.

                                                    10
Function




   Mitochondria are the site of most of the
    energy production in eukaryotic cells .




                                               11
 They use complex molecules and
  oxygen to produce a high energy
  molecule know as ATP (Adenosine
  Triphosphate)
 process called aerobic respiration




                                       12
   Energy production the mitochondria has
    been called the "powerhouse of the
    cell".




                                             13
 Mitochondria are very abundant in cells
  that require lots of energy.
 Ex:- Muscle




                                            14
Unique
   Mitochondria are very unique in several
    regards
    have their own circular DNA
    have their own Ribosomes.


    (The DNA in the cell nucleus does not code
      for the construction of mitochondria. )




                                                 15
 All the mitochondria in your body came
  from your mother.
 Mitochondria are not part of the genetic
  code in the nucleus of your cells.




                                             16
   Fathers only give genes to their children.

   Mothers give genes and cytoplasm to their
    children in their egg cells.

   Since mitochondria are in the cytoplasm and
    reproduce themselves they only are inherited
    from mothers




                                                   17
   Geneticists have used this curious
    feature of mitochondria to study
    maternal family lines and rates of
    evolution.




                                         18
   Although the primary function of mitochondria is to
    convert organic materials into cellular energy in
    the form of ATP, mitochondria play an important
    role in many metabolic tasks, such as:
   Apoptosis-Programmed cell death
   Glutamate-mediated excitotoxic neuronal injury
   Cellular proliferation
   Regulation of the cellular redox state
   Heme synthesis
   Steroid synthesis



                                                    19
   Heat production (enabling the organism to
    stay warm).
   Some mitochondrial functions are
    performed only in specific types of cells.
    For example, mitochondria in liver cells
    contain enzymes that allow them to
    detoxify ammonia, a waste product of
    protein metabolism. A mutation in the
    genes regulating any of these functions
    can result in a variety of mitochondrial
    diseases.

                                                 20

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Mitochondria

  • 2. 2
  • 3. 3
  • 4.
  • 5. Mitochondria The organelle that releases energy in the cell. (The powerhouse of the cell) Only found in ANIMAL cells. Mitochondria produce ATP using energy stored in food molecules.
  • 6. Mitochondria are the primary energy producers in cells. 6
  • 7. Structure  Mitochondria have a double membrane structure  There is a single outer membrane and a folded inner membrane 7
  • 8. Sac with two inner compartments which are separated by the inner membrane.  The first compartment is between the outer and inner membranes.  The outer compartment is inside the inner membrane. 8
  • 9. The outer mitochondrial membrane is composed of about 50% phospholipids by weight and contains a variety of enzymes involved in such diverse activities as the elongation of fatty acids, oxidation of epinephrine (adrenaline), and the degradation of tryptophan. 9
  • 10. The inner membrane contains proteins with three types of functions [Alberts, 1994]:  those that carry out the oxidation reactions of the respiratory chain  ATP synthase, which makes ATP in the matrix  specific transport proteins that regulate the passage of metabolites into and out of the matrix. 10
  • 11. Function  Mitochondria are the site of most of the energy production in eukaryotic cells . 11
  • 12.  They use complex molecules and oxygen to produce a high energy molecule know as ATP (Adenosine Triphosphate)  process called aerobic respiration 12
  • 13. Energy production the mitochondria has been called the "powerhouse of the cell". 13
  • 14.  Mitochondria are very abundant in cells that require lots of energy.  Ex:- Muscle 14
  • 15. Unique  Mitochondria are very unique in several regards have their own circular DNA have their own Ribosomes. (The DNA in the cell nucleus does not code for the construction of mitochondria. ) 15
  • 16.  All the mitochondria in your body came from your mother.  Mitochondria are not part of the genetic code in the nucleus of your cells. 16
  • 17. Fathers only give genes to their children.  Mothers give genes and cytoplasm to their children in their egg cells.  Since mitochondria are in the cytoplasm and reproduce themselves they only are inherited from mothers 17
  • 18. Geneticists have used this curious feature of mitochondria to study maternal family lines and rates of evolution. 18
  • 19. Although the primary function of mitochondria is to convert organic materials into cellular energy in the form of ATP, mitochondria play an important role in many metabolic tasks, such as:  Apoptosis-Programmed cell death  Glutamate-mediated excitotoxic neuronal injury  Cellular proliferation  Regulation of the cellular redox state  Heme synthesis  Steroid synthesis 19
  • 20. Heat production (enabling the organism to stay warm).  Some mitochondrial functions are performed only in specific types of cells. For example, mitochondria in liver cells contain enzymes that allow them to detoxify ammonia, a waste product of protein metabolism. A mutation in the genes regulating any of these functions can result in a variety of mitochondrial diseases. 20

Editor's Notes

  1. WINDSOR SOM CELL BIOLOGY Dr. PURNA