in this presentation me & my colleagues discuss briefly the types of mesenteric ischemia ( acute , chronic , venous ) and its related syndromes (superior mesenteric artery syndrome , celiac trunk syndrome and supply it by good radiologic images ..
in this presentation me & my colleagues discuss briefly the types of mesenteric ischemia ( acute , chronic , venous ) and its related syndromes (superior mesenteric artery syndrome , celiac trunk syndrome and supply it by good radiologic images ..
Brief description on the benign tumors of liver that includes hemangioma, focal nodular hyperplasia, regenerative nodular hyperplasia, dysplastic foci, dysplastic nodules and focal fatty change.
Abdominal pain is one of common problems
encountered by doctors, either in primary or
secondary health care (specialists). It may be
mild, but it may also a life-threatening sign. It
has been estimated that almost 50% adults have
experienced abdominal pain. In general, abdominal pain is categorized
based on the onset as acute or chronic pain.
Sudden onset of abdominal pain that lasts for less
than 24 hours is considered as acute abdominal
pain.
The problems of a surgeon
If 'I' operate 'and 'the' problem 'is' not 'surgical, Pt
exposed 'to' unnecessary 'risk ,'anesthetic,'etc.'
Risks 'greater' with 'concomitant 'illness,'older 'age'
If 'I' do 'not' operate 'and' problem 'is' surgical, 'patient 'at'
risk 'because' of 'wrong' therapy.'
Again 'the' older 'patient 'is' under 'greater' burden.'
Tuberculosis can affect any organ system, particularly in immunocompromised individuals Defined as tuberculosis infection of the abdomen involving the peritoneum and its reflections, gastrointestinal tract, abdominal lymphatics and solid visceral organs.
Often reveals a mass made up of matted loops of small bowel with thickened walls, diseased omentum, mesentery and loculated ascites
Regional lymph nodal enlargement
Extrapulmonary TB
Acute mesenteric ischemia; anatomy, pathophysiology and managementPezhman Kharazm
Acute mesenteric ischemia is one of the most problematic causes of acute abdominal pain. In this presentation, etiologies of acute mesenteric ischemia, their diagnostic evaluation and treatment are discussed.
Brief description on the benign tumors of liver that includes hemangioma, focal nodular hyperplasia, regenerative nodular hyperplasia, dysplastic foci, dysplastic nodules and focal fatty change.
Abdominal pain is one of common problems
encountered by doctors, either in primary or
secondary health care (specialists). It may be
mild, but it may also a life-threatening sign. It
has been estimated that almost 50% adults have
experienced abdominal pain. In general, abdominal pain is categorized
based on the onset as acute or chronic pain.
Sudden onset of abdominal pain that lasts for less
than 24 hours is considered as acute abdominal
pain.
The problems of a surgeon
If 'I' operate 'and 'the' problem 'is' not 'surgical, Pt
exposed 'to' unnecessary 'risk ,'anesthetic,'etc.'
Risks 'greater' with 'concomitant 'illness,'older 'age'
If 'I' do 'not' operate 'and' problem 'is' surgical, 'patient 'at'
risk 'because' of 'wrong' therapy.'
Again 'the' older 'patient 'is' under 'greater' burden.'
Tuberculosis can affect any organ system, particularly in immunocompromised individuals Defined as tuberculosis infection of the abdomen involving the peritoneum and its reflections, gastrointestinal tract, abdominal lymphatics and solid visceral organs.
Often reveals a mass made up of matted loops of small bowel with thickened walls, diseased omentum, mesentery and loculated ascites
Regional lymph nodal enlargement
Extrapulmonary TB
Acute mesenteric ischemia; anatomy, pathophysiology and managementPezhman Kharazm
Acute mesenteric ischemia is one of the most problematic causes of acute abdominal pain. In this presentation, etiologies of acute mesenteric ischemia, their diagnostic evaluation and treatment are discussed.
tutorials in surgery, surgery training curriculum, residency in surgery, surgical education, principles of surgery, operative surgery, surgical anatomy, pathology and radiology, research methodology, surgery mcqs, surgery essay writing, part 1 exams, part 2 fellowship exams.
resident doctors. medical officers and house officers
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. INTRODUCTION
• Mesenteric vascular occlusion or mesenteric ischemia is a lethal
condition resulting from critically reduced perfusion to the GIT.
• Despite advances in vascular surgery, it still remains a complex and
disheartening disease with high mortality.
• It account for 1-2% of admissions for abdominal pain.
• Account for 9 in 100,000 persons per year, incidence increase with
age and its commoner in women.
• Mortality is 24-96 % with average of 69%.
4. ANATOMY OF MESENTERIC VASCULATURE
• Comprises of 3 major aortic branches with collaterals
• Celiac axis
• Superior mesenteric artery
• Inferior mesenteric artery
• Marginal Artery of Drummond – Anastomotic collateral between SMA
and IMA
16. MANAGEMENT
• RESUSCITATION
• IV FLUIDS
• NG TUBE
• BROAD SPECTRUM ANTIBIOTICS
• ANALGESICS
• BLOOD TRANSFUSION
• MONITORING OF VITAL SIGNS
17. DIAGNOSIS
• Diagnosis is delayed in up to two-third of patient with mesenteric
ischemia.
• Outcome is related prompt diagnosis and initiation treatment
18. DIAGNOSIS
• HISTORY;
• ‘High index of suspicion’
• Classical- abdominal pain out of proportion to the findings on
physical examination and persisting beyond 2-3hours (spasms from
ischemia)
• Bleeding per rectum/ malena 15%
• Bilous vomiting
• Abdominal distention
19. • History of aetiology/risk factors;
• History suggestive of cardiac or vascular disease; cardiomyopathy, MI
• Non –occlusive; pancreatitis, sepsis, heart failure, burns, cardiac bypass,drugs
• Venous occlusion; hypercoagulable state, sepsis, pregnancy, malignancy
• Family history
• Smoking
• Hypertension
• Hypercholesterenemia
20. • Physical examination;
• Painful distress, may be pale, fever(advance disese), tarchycardia,
hypotension, irregular pulse(arrhythmia), cardiac murmurs
• distended abdomen, guarding, rigidity, rebound tendeness
• NB; normal abdomen in the face of severe abdominal pain in the
early stage.
21. INVESTIGATIONS
• Radiological; positive findings are usually late and non specific
• Plain andominal X-ray
• Majority of cases are Non diagnostic
• Dilated bowel loops
• Thumb printing
• Intramural gas
• Free air
22.
23.
24.
25. • Ultrasonography – limited utility in acute mesenteric ischemia
• CT Scan;
• Dilatation of the bowel lumen
• Bowel wall thickening from oedema or hemorrhage
• Abnormal bowel wall enhancement, lack of enhancement indicate infarction
• Intraluminal thrombous
• Intralmural or portal venous gas
26. • Symmetrical bowel wall thickening greater than 3mm in a distended
segment of bowel suggests ischemia
• Greater degrees of bowel wall thickening should raise suspicion of
mesenteric venous thrombosis (MVT)
• Intravenous contrast is useful in demonstrating the heterogeneity of
the ischemic bowel wall (lack of bowel wall enhancement) and may
show occlusion of mesenteric arteries if given by rapid bolus
administration
27.
28. • Sensitivity 64%
• Specificity 92%
• CT is the diagnosis technique of choice for acute MVT- sensitivity is
90%
• 3 D recon of the aorta and its branches show additional detail –
sensitivity and specificity to 94 to 96%
• The limitation and risk of CT angiography
• Renal insufficiency or contrast allergy
• Limitation of contrast volume and mental artefacts obscuring the area of
interest
29.
30.
31. ANGIOGRAPHY
• Definitive diagnosis - acute and chronic mesenteric ischemia.
• Arteriograms
• Establish the diagnosis
• Differentiate between acute embolic, thrombotic, or non-occlusive
mesenteric ischemia
• Allow proper planning of the revascularization procedure.
• AP and lateral views of the aorta and the mesenteric branches are required
for proper arteriographic evaluation.
• The lateral view is particularly important to examine the proximal celiac artery
and SMA, which overlap the aortic contrast column on AP views.
32.
33.
34. • Acute embolic occlusion of the SMA is abrupt occlusion of the artery,
usually at a branch point where the vessel tends to narrow
• If imaged acutely, a meniscus sign (crescent) is often observed.
• If secondary thrombosis occurs proximal to the embolus, the classic
meniscus sign of embolic occlusion will be obscured.
35. Advantages of angiography
• Dissolving a blood clot with agents
• Opening a partially blocked artery with a balloon
• Placing a small tube called a stent into an artery to help hold it open
40. TREATMENT
• Surgical treatment; surgery is the mainstay of treatment, medical
treatment with vasodilators, thrombolytics and anticoagulant are
used as adjuncts to surgery and endovascular therapy.
• Endovascular Treatment;
41. MEDICAL TREATMENT
• Vasodilators e. g Papaverine : is phosphodiesterase inhibitor, which
acts to relax vascular smooth muscle and causes vasodilation.
• Thrombolytics : The infusion must be started within 8 hours of
symptom onset. E.g urokinase, recombinant t- PA
• Anticoagulants; heparin and warfarin use in venous thrombosis and
post-operatively after embolectomy or bypass
• Antibiotics.
• Analgesics.
43. ENDOVASCULAR TREATMENT
• Catheter-directed thrombolytic therapy is a potentially useful
treatment modality.
• Initiated with intra-arterial delivery of thrombolytic agent into the
mesenteric thrombus at the time of diagnostic angiography.
• Urokinase or recombinant tissue plasminogen activator have been
reported to be successful
• Catheter-directed thrombolytic therapy has a higher probability of
restoring mesenteric blood flow success when performed within 12
hours of symptom onset.
44. • Successful resolution of a mesenteric thrombus - facilitate the
identification of the underlying mesenteric occlusive disease process.
• Subsequent operative mesenteric revascularization or mesenteric
balloon angioplasty and stenting may be performed electively
• Main drawbacks
• Percutaneous, catheter-directed thrombolysis (CDT) does not allow the
possibility to inspect the potentially ischemic intestine following restoration
of the mesenteric flow.
• Prolonged period of time - achieve successful CDT,
• An incomplete or unsuccessful thrombolysis
46. SURGICAL TREATMENT
• Operative intervention remains the mainstay of management
• The surgeon's goal is to confirm the diagnosis
• Assess bowel viability,
• Determine the responsible etiology,
• Perform revascularization where possible
• Resect nonviable bowel
47. • Indications;
• Failed thrombolytic therapy- no evidence of reperfusion after 4 hours
• Presentation after 8 hours of onset of pain
• Features of peritonitis
48.
49. SUPERIOR MESENTERIC ARTERY EMBOLECTOMY
• The abdomen is explored - midline incision - reveals variable degrees of
intestinal ischemia from the mid jejunum to the ascending or transverse
colon.
• The omentum and transverse colon are lifted cephalad.
• All small bowel is retracted to the right, and the sigmoid colon packed to
the left.
• The ligament of Treitz and the superior attachments of the duodenum are
sharply divided, with the goal of mobilizing the last portion of the
duodenum to the right.
• Then, with four fingers behind the small bowel mesentery and with the
thumb anteriorly, the SMA should be palpable near the base of the
transverse colon mesentery.
50. • Alternatively, after lifting the transverse colon, the SMA can also be
identified by following the middle colic artery until it enters the SMA
at the root of the mesentery.
51. • The SMA has a larger caliber proximal to the middle colic origin, making for
technically easier arteriotomy.
• Once the proximal SMA is identified it is controlled with vascular clamps,
• An approximately 3-4 cm length of artery is exposed and
vessel loops placed for proximal and distal control.
• A transverse arteriotomy may be used.
• Fogarty balloon catheter embolectomy is performed both proximally and
distally.
• Good back-bleeding and inflow suggest that the entire embolus has been
removed
• Bowel resection is performed as appropriate. A second-look exploration, 24-
48 hours following embolectomy, should be considered in many patients.
52. SMA embolectomy.
(a)Location of embolus within SMA is identified.
(b)Transverse or longitudinal arteriotomy is performed, and embolus is
extracted with balloon catheter.
(c)Arteriotomy is closed. Primary closure suffices for transverse arteriotomy, but vein patch is usually required
for closure of longitudinal arteriotomy
53.
54. • Following the restoration of SMA flow,
• Assessment of intestinal viability must be made,
• Nonviable bowel must be resected.
• Several methods
• Intraoperative IV fluorescein injection and inspection with a Wood's lamp
• Doppler assessment of antimesenteric intestinal arterial pulsations.
• A second-look procedure - 24 to 48 hours following embolectomy.
• The goal of the procedure is reassessment of the extent of bowel
viability, which may not be obvious immediately following the initial
embolectomy.
55.
56. SMA BYPASS
• Thrombotic mesenteric ischemia - severely atherosclerotic vessel
• Typically the proximal SMA.
• Require a reconstructive procedure to the SMA to bypass the
proximal occlusive lesion and restore adequate mesenteric flow.
• The saphenous vein is the graft material of choice
• Prosthetic materials should be avoided in patients with nonviable
bowel, due to the risk of bacterial contamination if resection of
necrotic intestine is performed.
57. • Bypass grafting types:
• Antegrade from supraceliac aorta
• Retrograde from infrarenal aorta
61. • Retrograde bypass is performed by first identifying a soft
portion of the distal aorta or common iliac artery.
After completion of the distal SMA anastomosis, the conduit
is stretched to lie taut along the left side of the aorta and
proximal anastomosis is performed.
• The graft should lie with a fair amount of tension to avoid laxity and
kinking.
• In retrograde bypass the limited dissection and avoidance of supraceliac
aortic occlusion make this option attractive
62. FUTURE DIRECTION
• Intestinal ischemia results in formation of free radicals
• Free radicals promote systemic release of bacterial toxins
• Systemic release of toxins leads to pulmonary complications
and distant organ disease.
• Various medications and hyperbaric oxygen continue being
studied to limit this form of injury- ISCHEMIC REPERFUSION
INJURY
63. Conclusion
• The management of mesenteric vascular occlusion is challenging even
in areas with improved facilities. High index of suspicion, early
detection, aggressive resuscitation and restoration of blood flow are
paramount for successful outcome.
64. References
• Micheal J, Stanley W. “Maingot’s Abdominal Operations”. Twelfth
edition. The McGraw-Hill companies, 2013.
• Andrew B. Mesenteric Ishemia; Ghana Emergency Medicine
Collaborative. michigan@umich.edu.
• www.slideshare .net
• E.A Badoe et al, “Principles and Practice of surgery including
pathology in the tropics” 4th edition, Assembly of God Literature
Center ltd, 2009
• Sriram Bhat S “SRB manual of surgery” 4th edition Jaypee Brothers
Medical Publishers (P) Ltd