Measures of dispersion
Absolute measure, relative measures
Range of Coe. of Range
Mean deviation and coe. of mean deviation
Quartile deviation IQR, coefficient of QD
Standard deviation and coefficient of variation
Measures of Central Tendency
Requirements of good measures of central tendency
mean, median, mode
skewness of distribution
relation between mean, median,mode
Measures of dispersion
Absolute measure, relative measures
Range of Coe. of Range
Mean deviation and coe. of mean deviation
Quartile deviation IQR, coefficient of QD
Standard deviation and coefficient of variation
Measures of Central Tendency
Requirements of good measures of central tendency
mean, median, mode
skewness of distribution
relation between mean, median,mode
Frequency distribution, types of frequency distribution.
Ungrouped frequency distribution
Grouped frequency distribution
Cumulative frequency distribution
Relative frequency distribution
Relative cumulative frequency distribution
Graphical representation of frequency distribution
I. Representation of Grouped data
1.Line graphs
2.Bar diagrams
a) Simple bar diagram
b)Multiple/Grouped bar diagram
c)Sub-divided bar diagram.
d) % bar diagram
3. Pie charts
4.Pictogram
II. Graphical representation of ungrouped data
1, Histogram
2.Frequency polygon
3.Cumulative change diagram
4. Proportional change diagram
5. Ratio diagram
This presentation includes an introduction to statistics, introduction to sampling methods, collection of data, classification and tabulation, frequency distribution, graphs and measures of central tendency.
Standard error is used in the place of deviation. it shows the variations among sample is correlate to sampling error. list of formula used for standard error for different statistics and applications of tests of significance in biological sciences
Frequency distribution, types of frequency distribution.
Ungrouped frequency distribution
Grouped frequency distribution
Cumulative frequency distribution
Relative frequency distribution
Relative cumulative frequency distribution
Graphical representation of frequency distribution
I. Representation of Grouped data
1.Line graphs
2.Bar diagrams
a) Simple bar diagram
b)Multiple/Grouped bar diagram
c)Sub-divided bar diagram.
d) % bar diagram
3. Pie charts
4.Pictogram
II. Graphical representation of ungrouped data
1, Histogram
2.Frequency polygon
3.Cumulative change diagram
4. Proportional change diagram
5. Ratio diagram
This presentation includes an introduction to statistics, introduction to sampling methods, collection of data, classification and tabulation, frequency distribution, graphs and measures of central tendency.
Standard error is used in the place of deviation. it shows the variations among sample is correlate to sampling error. list of formula used for standard error for different statistics and applications of tests of significance in biological sciences
This slideshow explains the important measures of central tendency in statistics. It deals with Mean, mode and median; its characteristics, its computation, merits and demerits. This slideshow will be useful to students, teachers and managers.
Exploring Measures of Central Tendency
In this presentation, we delve into the fundamental concept of Measures of Central Tendency. These statistical tools - Mean, Median, and Mode - are at the heart of data analysis, guiding us to understand where the center of our data lies.
We explore each measure's definition and its unique role in analyzing data. Learn when to wisely apply mean, median, or mode based on your data's distribution. Discover the real-life applications that make these concepts crucial in various industries.
By grasping the significance of central tendency, you'll be better equipped to make informed decisions and draw meaningful conclusions from your data. Join the discussion and deepen your understanding of these fundamental statistical tools.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. “It is a sort of average or typical value of the
items in the series and its function is to
summarise the series in terms of this average
value”
Central tendency may be considered as synonym of
average. Averages, are generally the central part of
the distribution and therefore they are also called the
measures of central tendency.
The measures of central tendency is defined as :-
Introduction
3. Types of Measures of Central Tendency :-
There are usually three basic measures of central tendency. These
are :
(1)Mathematical average
(2)Average of position
(3)Measures of partition values
1. Mathematical average :-Average represented purely in
mathematical values are known as mathematical average. It is of
three types :-
(i) Arithmetic mean
(ii) Geometric mean
(iii) Harmonic mean.
4. 2. Average of position :- Mean exhibited by
position is called average of position. It is of
two types:-
(i) Median
(ii) Mode.
3.Measures of partition value:- It is measures of
location. It divides the total observations by an
imaginary line into two or more parts
expressed in percentage.
5. MATHEMATICAL AVERAGE
1. Arithmetic mean:- Average obtained
arithmetically is collect Arithmetic mean.
Arithmetic mean can be obtained both
ungrouped data and grouped data.
(i) Ungrouped data :- If the values of N items are
X1, X2, X3, Xn...... Be the value of variate X, then
simple arithmetic mean ( ) is obtained by dividing
the sum of the values of all the items by the total
number of observations
7. (ii) Grouped data :- When data is presented in frequency
distribution then mean can be obtained by two methods.
(a) Discrete series
(b) continuous series
(a) Discrete series :- If data is in frequency distribution but not
in class interval, then it is called as discrete series.
11. MERITS AND DEMERITS OF ARITHMETIC MEAN
Merits :-
• It is rightly defined and is an easy and ideal
measures of central tendency.
•It covers all the observations and is easy to
calculate.
•It is affected least by fluctuation of sampling. In
other words arithmetic mean is a stable average.
•Arithmetic mean provides base of many other
methods of statistics.
12. Demerits :-
Obtained mean in a series may not be represented
by any observation.
It is very much affected by extreme observation.
By eliminating even a single series, calculation
becomes unreal.
It cannot be determined by inspection nor can be
represented graphically.
In extremely skewed distribution arithmetic mean is
not representative of the distribution.
13. 2. GEOMETRIC MEAN
The geometric mean is defined as the Nth
root of the product of n observations.
15. MERITS AND DEMERITS OF GEOMETRIC MEAN
Merits:-
• It is based on all the observations.
•It is rigidly defined.
•It is capable of further algebraic
manipulation.
•It is not much affected by fluctuation of
sampling.
•It is particularly useful in dealing with
ratios, rates and percentages.
16. Demerits :-
•It cannot be used when any of the
quantities are zero or negative.
•It is difficult to calculate and interpret.
•It may come out to be a value which is
not existing in the series.
17. 3. HARMONIC MEAN
The Harmonic mean is defined as the “reciprocal of
the arithmetic mean of the reciprocals of the given
values” . For e.g. , reciprocal of 5 is 1/5, reciprocal
of 9 is 1/9 and so on. If variables are expressed in
ratios or rates, the proper average to be used is
Harmonic mean.
19. MERITS AND DEMERITS OF HARMONIC
MEAN
Merits :-
• It is rightly defined.
•It is based on all observations of a series.
•It gives greater weightage to the smaller
items.
•It is useful to study the rate of respiration,
rate of pulse, heart beat etc. In unit time.
•It is not much affected by sampling
fluctuations.
20. Demerits:-
•It is not easy to calculate and understand.
•It cannot be calculated if one value is zero.
•It cannot be calculated if negative and
positive values are given in a series.
Relationship between Arithmetic mean,
Geometric mean and Harmonic mean
AM>GM>HM.
21. AVERAGE OF POSITION
MEDIAN:-
The value of the middle most observation,
when the data are arranged in ascending or
descending order of magnitude, is called the
median of the data.
24. MERITS AND DEMERITS OF MEDIAN
Merits :-
•If found directly, it represents an actual item.
•The values of only the middle items are required
to be known.
•It is easy to calculate.
•It can also used in qualitative measures.
•It eliminates the effects of extreme items, since
they are not taken into account in its calculations,
except for arranging the data in increasing or
decreasing order.
25. Demerits:-
•Arithmetic explanation of median is not possible.
•To obtain data must be kept in ascending order
or descending order.
•It gives equal importance to all series.
•It is not very useful in further analysis, because it
is difficult to handle mathematically.
26. MODE
Mode is that value which is repeated maximum
times in a series. In other words we can say that
the mode is that value which has the maximum
frequency.
28. MERITS AND DEMERITS OF MODE
Merits :-
•It avoids the effects extreme items.
•Often it can be ascertained by mere inspection.
•Only the values occurring with high frequencies are
required to be known for its determination. All
values need not be known.
•Bi-modal distribution may give a good indication of
the heterogeneity of a population.
29. Demerits:-
•It is not well defined and is rarely used for
higher life science researchers.
•Arithmetic explanation of mode is not
possible.
•Sometimes it is indefinite.
•It becomes difficult in multi-modal
distribution.
•It is not based on all the observation of a
series.
30. Relationship between Mean, Median,
and Mode
There is empirical relationship between Mean,
Median and Mode of a series of items . If distribution
of item values be symmetrical then the Mean,
median and Mode coincides, otherwise the distance
between the Mode and Median is usually twice the
distance the Median and the Mean. Thus:-
Mode-Median=2(Median-Mean)
Or, Mode-Mean=3(Median-Mean)