#MCQ ON AMINO ACIDS AND PEPTIDES#FOR IIT JAM, NET, GATE#PREVIOUS YEAR QUESTIONS AND SOLUTION WITH TRICKS#BIOORGANIC Amino acids and Peptides chapter comes under Bioorganic Chemistry. From this chapter many MCQ asked in various types of competitive examinations like IIT JAM, CSIR NET and GATE examinations. So in this video I have covered all possible practice questions base on above topic also discussed the solution with proper tricks based on theory. Further also I have solved all the MCQ asked regarding Amino acids and Peptides in IIT JAM, CSIR NET and GATE examinations from 2007-2022. I believe that after watching this video you will able to solve all the questions regarding above topic easily.

1. MCQ ON
AMINO ACIDS AND
PEPTIDES
FOR
IIT JAM, NET, GATE
BY
Dr. ASHIS KUMAR SAHOO
IIT KANPUR

2. Q1. Amino Acid is the Monomer of which Biomolecule
A. Carbohydrates
B. Proteins
C. Nucleic Acids
D. Lipids

3. Q 2. WHICH ONE IS THE CORRECT MATCHING
A B
Carbohydrate Amino acid
Protein Glycerol
Nucleic Acid Manosaccharides
Lipid Nucleotides
A B
Carbohydrate Manosaccharides
Protein Amino acid
Nucleic Acid Nucleotides
Lipid Glycerol

4. Q 3 Amino acid contains which functional groups ?
A. Carboxylic B. Amine
B. C. Both Amine and carboxylic acid D. None

5. Q 4 How many amino acids take part in protein synthesis?
A. 22 B. 20 C. 21 D 10
Q 5 How many amino acids known as proteinogenic or natural?
A. 22 B. 20 C. 21 D 10
Q 6 How many amino acids are encoded by universal genetic code
A. 22 B. 20 C. 21 D 10

6. 1. ALANINE
2. ARGININE
3 ASPARTIC ACID
4.ASPARAGINE
5.CYCTEINE
6.GLYCINE
7.GLUTAMIC ACID
8.GLUDAMINE
9.HISTIDINE
10. ISOLEUCINE
11.LEUCINE
12.LYSINE
13.METHIONINE
14.PHENYL ALANINE
15. PROLINE
16. SERINE
17.TYROSINE
18.TRYPTOPHAN
19.THREONINE
20.VALINE
21.SELENOCYSTEINE
22. PYRROLYSINE
LIST OF 22 AMINOACIDS
ALPHABETICALLY

7. C
H
H
H2N COOH
GLYCINE
C
H
H3C
H2N COOH
ALANINE
C
H
H2C
H2N COOH
PHENYLALANINE
C
H
H2C
H2N COOH
OH
TYROSINE

8. C
H
H2C
H2N COOH
OH
SERINE
C
H
H2C
H2N COOH
SH
CYSTEINE
C
H
H2C
H2N COOH
N
H
TRYPTOPHAN
C
H
H2C
H2N COOH
NH
N
HISTIDINE

9. C
H
H2C
H2N COOH
COOH
ASPARTIC ACID
C
H
H2C
H2N COOH
CONH2
ASPARAGINE
C
H
CH
H2N COOH
CH3
H3C
VALINE
C
H
CH
H2N COOH
CH3
HO
THREONINE

10. C
H
H2C
H2N COOH
CH2
H2NOC
GLUTAMINE
C
H
H2C
H2N COOH
CH2
HOOC
GLUTAMIC ACID
C
H
H2C
H2N COOH
CH2
H3CS
METHIONINE
C
H
H2C
H2N COOH
CH
H3C
CH3
LEUCINE
C
H
CH
H2N COOH
CH2
H3C
ISOLEUCINE
H3C

11. C
H
H2C
H2N COOH
CH2
H2C
H2
C
NH2
LYSINE
C
H
H2C
H2N COOH
CH2
H2C
H
N
ARGININE
C
NH
NH2
N
H
COOH
PROLINE

12. C
H
H2C
H2N COOH
SeH
SELENOCYSTEINE
C
H
H2C
H2N COOH
CH2
H2C
H2
C
N
H
C
O
N
H3C
PYRROLYSINE

13. Q.7 Which amino acid contains imidazole ring?
A. Alanine B. Tryptophan C. Histidine D. Tyrosine
Q. 8 Which amino acid contains indole ring?
A. Proline B. Isoleucine C. Arginine D. Tryptophan
Q 9. Which amino acid contains Phenolic group?
A. Tyrosine B. Tryptophan C. Threonine D. Serine
Q. 10. Which amino acid the amino group present in as secondary amine?
A. Histidine B. Proline C. Lysine D. Cysteine
Q. 11. Which amino acid contain thiol or mercaptan group?
A. Cysteine B. Serine C. Threonine D. Methionine
Q. 12. Which amino acid contain isopropyl group?
A. Valine B. Glutamic acid C. Aspartic Acid D. Methyonine

14. Q 13. Which statement is false
A. Amino acids are generally colourless crystalline solids
B. Amino acids are soluble in water due to Zwitter ionic form
C. Amino acids are low melting solids
D. All amino acids are amphoteric in nature
Q 14. Isoelectric point (pI) of an Amino acid is the
A. The temperature at which amino acids melts
B. The pH at which amino acids remain in cationic form
C. The pH at which amino acid remain in Zwitter ionic form
D. The pH at which amino acids remain in anionic form
Q 15. Which one is correct behaviour of an amino acid when placed in electric field
A. At low pH , AA remain in cationic form migrates towards cathode
B. At high pH , AA remain in anionic form migratyes towards anode
C. At an intermediate pH AA remain in electrically neutral form
D. ALL

15. Isoelectric point :
Amino acids are hydrophilic colloids. Depending upon the pH of the
medium, they move either towards the anode or towards the cathode
when placed in an electric field.
In acid solution (low pH), the zwitter ion takes up a proton from the acid
and exists as cation. So, it migrates towards the cathode.
In alkaline solution (high pH) the zwitter ion donates a proton to the
alkali and exists as anion. So, it migrates towards the anode. Amino
acid bears a positive charge in acidic solution (low pH) and a negative
charge in basic solution (high pH).
There must be an intermediate pH where the amino acid is evenly
balanced between the two forms, as the dipolar zwitterion with a net
charge of zero. This pH is called the isoelectric pH or the isoelectric
point.

16. Q. 16. What is the isoelectric point of Glycine from given data?
O
NH2
OH
pKa= 2.35
pKa=9.78
Q 17. What is the isoelectric point of Proline from given data?
H
N
O
OH
pKa= 2.00
pKa=10.60

17. Q. 18. Calculate the isoelectric point of Aspartic Acid from the given pKa value?
HO
NH2
O
O-
O
pKa=3.71
pKa=9.66
pKa=1.95
Q. 19. Calculate the isoelectric point of Glutamic Acid from the given pKa value?
HO
NH2
O
pKa=4.15
pKa=9.58
pKa=2.16
O-
O

18. Q. 20. Calculate the isoelectric point of Cysteine from the given pKa value?
Q. 21 Calculate the isoelectric point of Tyrosine from the given pKa value?
HO SH
NH2
O
pKa=8.00
pKa=10.25
pKa=2.05
HO
NH2
O
pKa=10.07
pKa=9.11
pKa=2.20
OH

19. Q. 22 Calculate the isoelectric point of Lysine from the given pKa value?
Q. 23 Calculate the isoelectric point of Histidine from the given pKa value?
HO
NH2
O pKa=10.53
pKa=8.95
pKa=2.18
NH3
+
HO
NH2
O
pKa=6.10
pKa=9.18
pKa=1.07
N
NH

20. Q. 24 Calculate the isoelectric point of Arginine from the given pKa value?
HO
NH2
O
pKa=12.48
pKa=9.04
pKa=2.01
H
N
NH2
+
NH2

21. For negative charged amino acids PI = sum of two small pKa/2
For positive charged amino acids PI = sum of two larger pKa/2

22. 25. Which amino acid is not an Eessential amino acid?
A. Valine B. Lysine C. Alanine D. Tryptophan
26. Which amino acid is hydrophilic (polar) amino acid?
A. Histidine B. Phenylalanine C. Valine D. Isoleucine
27 Which on is Negative charged amino acids?
A. Aspartic acid B. Lysine C. Arginine D. histidine

23. ALANINE
ASPARTIC ACID
ASPARAGINE
CYCTEINE
GLYCINE
GLUTAMIC ACID
GLUDAMINE
HISTIDINE
ISOLEUCINE
LEUCINE
LYSINE
METHIONINE PROLINE
SERINE
TYROSINE
VALINE
ESSENTIAL AA NONESSENTIAL AA
PHENYL ALANINE
ARGININE
TRYPTOPHAN
THREONINE
VIP HALL Me TT
HISTIDINE
ARGININE
SEMIESSENTIAL

24. PREVIOUS YEAR QUESTION
ASKED ON
AMINO ACIDS, PEPTIDES
AND PROTEINS

25. JAM 2020

26. JAM 2019

27. JAM 2016

28. JAM 2015

29. JAM 2010

30. JAM 2009

31. GATE 2012

32. GATE 2010

33. GATE 2014

34. NET 2020 NOV

35. NET 2016 JUNE

36. NET 2016 JUNE

40. NET 2014 JUNE

41. NET 2014 DEC

42. NET 2014 JUNE

43. NET 2013 DEC

44. NH2
O
HO
COOH
N
H
NHPh
(S)-2-aminopentanedioic acid
PhNH2
NH2
O
HO
CONHPh
(S)-2-aminopentanedioic acid
O
O
LiAlH4
N
H
NHPh
N-(((S)-pyrrolidin-2-
yl)methyl)benzenamine

45. NET 2014 JUNE
Cysteine contain sulphur and Cd and Hg are highly philic to
sulphur... so cysteine binds Hg and Cd and hence their toxicity decreases.
Soft acid prefer soft base

46. NET 2012 JUNE

47. NET 2012 DEC

48. NET 2011 DEC

49. GATE 2022

50. Determination of N-terminal amino acid
•By The Edman Degradation
By Sanger’s reagent
2,4-dinitrofluorobenzene (DNFB) is called Sanger’s
reagent.
Determination of C-terminal amino acid
By enzyme carboxypeptidase,

53. GATE 2018
Ala-Gly-Phe-Leu
Ala-Gly-Leu-Phe
Ala-Leu-Phe-Gly
Ala-Leu-Gly-Phe
Ala-Phe-Leu-Gly
Ala-Phe-Gly-Leu

54. GATE 2013

55. GATE 2009

56. GATE 2008
Hydrolyze the peptide into smaller fragments.
Trypsin - Cleaves at lys and arg
Chymotrypsin - Cleaves at phe, tyr, and trp
Pepsin - Cleaves at phe, tyr, trp, leu, asp, glu
Cyanogen bromide (not enzymatic) - Cleaves at met

57. GATE 2007
Hydrolyze the peptide into smaller fragments.
Trypsin - Cleaves at lys and arg
Chymotrypsin - Cleaves at phe, tyr, and trp
Pepsin - Cleaves at phe, tyr, trp, leu, asp, glu
Cyanogen bromide (not enzymatic) - Cleaves at met

58. trypsin
trypsin
BrCN
BrCN
ser-met-ala-phe-lys-leu-gly-leu-leu-phe
ala-leu-gly-met-lys-trp-phe-arg-ala-ala
trypsin
trypsin
trypsin
trypsin
BrCN
BrCN
ser-met-ala-phe-lys-leu-gly-leu-leu-phe
ala-leu-gly-met-lys-trp-phe-arg-ala-ala

59. JAM 2018

60. JAM 2017

61. NET 2020 NOV

62. NET 2013 JUNE

63. NET 2013 DEC

64. NET 2013 DEC

65. NET 2012 DEC