Magnetic resonance imaging (MRI) uses powerful magnets and radio waves to generate detailed images of the inside of the body. It was first developed in the 1970s and allows doctors to diagnose issues without exposing patients to radiation. An MRI scan works by aligning hydrogen atoms in the body using magnetism and radio waves. This causes the atoms to emit signals that are picked up by antennas and used by a computer to construct cross-sectional images of tissues and organs. MRI is useful for dental applications as it can image soft tissues like tooth pulp and the temporomandibular joint with high resolution, aiding in diagnosis and treatment planning.
This is a presentation describing in brief regarding the physics behind MRI and it's application from dental point of view. It contains few videos as well.
MRI Scanner, Instrumentation. MDIRT ST. Louis Bamenda, Nchanji Nkeh KenethNchanji Nkeh Keneth
The MRI Scanner; historical facts, Understanding Nuclear Magnetic Resonance, The Scanner componenets, Radiofrequency coils, the casing, types of MRI magnets, understanding the principle of superconductivity. MRI applications
This is a presentation describing in brief regarding the physics behind MRI and it's application from dental point of view. It contains few videos as well.
MRI Scanner, Instrumentation. MDIRT ST. Louis Bamenda, Nchanji Nkeh KenethNchanji Nkeh Keneth
The MRI Scanner; historical facts, Understanding Nuclear Magnetic Resonance, The Scanner componenets, Radiofrequency coils, the casing, types of MRI magnets, understanding the principle of superconductivity. MRI applications
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Xeroradiography is the production of visible image utilizing the charged surface of a photoconductor (amorphous selenium) as the detecting medium, partially dissipating the charge by exposure to X rays to form a latent image and making the latent image visible by xerographic processing.
Nhận viết luận văn đại học, thạc sĩ trọn gói, chất lượng, LH ZALO=>0909232620
Tham khảo dịch vụ, bảng giá tại: https://vietbaitotnghiep.com/dich-vu-viet-thue-luan-van
Download luận án tiến sĩ ngành y học với đề tài: Hiệu quả sát khuẩn ống tủy bằng natri hypoclorit, calcium hydroxide và định loại vi khuẩn trong điều trị viêm quanh cuống răng mạn tính, cho các bạn tham khảo
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Xeroradiography is the production of visible image utilizing the charged surface of a photoconductor (amorphous selenium) as the detecting medium, partially dissipating the charge by exposure to X rays to form a latent image and making the latent image visible by xerographic processing.
Nhận viết luận văn đại học, thạc sĩ trọn gói, chất lượng, LH ZALO=>0909232620
Tham khảo dịch vụ, bảng giá tại: https://vietbaitotnghiep.com/dich-vu-viet-thue-luan-van
Download luận án tiến sĩ ngành y học với đề tài: Hiệu quả sát khuẩn ống tủy bằng natri hypoclorit, calcium hydroxide và định loại vi khuẩn trong điều trị viêm quanh cuống răng mạn tính, cho các bạn tham khảo
MAGNETIC RESONANCE IMAGING QUESTION AND ANSWER 3 MARKS.pdfGanesan Yogananthem
Dear B.Sc MIT Students,
Attached is an essential document featuring comprehensive Questions & Answers for MAGNETIC RESONANCE IMAGING. We encourage you to utilize this resource to deepen your understanding and excel in your studies. Wishing you all the success in your academic endeavors and future careers.
Best regards,
basic and brief but informative knowledge about what basically MRI is ...
easy to understand as well as presenting during lectures and in classes . share it
This presentation discusees a brief history of the MRI, it's mechanism of action, applications in dentistry and recent advancements in its technology. Also it's advantages and disadvantages in comparison with the CT scan
MRI uses a strong magnetic field and radio waves to create detailed images of the organs and tissues within the body.
Developed by the Lauterbur in 1972 at Stony brook in New York.
MRI does not involve radiation
MRI contrasting agent is less likely to produce an allergic reaction that may occur when iodine-based substances are used for x-rays and CT scans
MRI gives extremely clear, detailed images of soft-tissue structures that other imaging techniques cannot achieve
The MRI machine cannot just simply “see the hydrogen nuclei which lie “hidden” in the water molecules distributed in the patient.
It needs to do ‘something’ to the hydrogen nuclei to detect their presence.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
3. HISTORY
The first patent of MRI technology was filed by
Raymond Damadian in 1972. The doctor and
researcher discovered that images created using MRI
technology could be helpful during the process of
diagnosing a patient. Damadian was the first person
to use MRI to make a medical diagnosis.
4. Definition
Magnetic Resonance
It is a non-invasive method for mapping internal structure within the body which uses non-
ionizing electromagnetic radiation and employes radio frequency radiation in the presence
of carefully controlled magentic fields to produce high quality cross-sectional images of the
body in any plane.
6. Magnetic Resonance Imaging Components
help to make Diagnost image.
How does it creates diganostic image.
First mapping internal structure within the body
Uses non-ionizing electromagnetic radiation(RF),
employes radiofrequency radiation in the presence of carefully controlled
magnetic fields to produce high-quality
cross-sectional images of the body in any plane
The magnetic component create a strong magnetic to change the spin of the
atoms in the bodies and radio signals detect these tiny changes.
Finally the computer process this information and construct images of soft
tissue inside the body,from brain to blood vessels.
16. Application
Efficacy Of Magnetic Resonance Imaging in dentistry.
Non-ionzing radiation Diagnostics Imaging
Soft tissue such as paranasal sinus tooth pulp
Successful restorative treatment mapping the shape of dental cavities.
Obtain high contrast between cavities and tooth(SWIFT).
High-resolution anatomical detail
Diagnosis TMJ joint disorders
17. Draws Back in MRI in Dentistry.
Image artifacts can be seen this may due to metal materials and patient
movements also,examinations can be expensive. Some medical and
dental centers have limited access.
18. The Principle of (MRI )
works by obtaining a resonance signal from the hydrogen
nucleus, and therefore, is essentially an imaging of water
in the tissue. Moreover the spin echo and inversion
recovery are the two most commonly used imaging
sequences.
Spinning Atoms (hydrogen) face outside magnetic field
Energy Absorption by RF Coils .
19. Resonance of Hydrogen atoms Measured by RF antenna
which the received signal is sinusoidal in shape.
Imaging by the computer which receives mathematical
data, which is converted through the use of a Fourier
transform into an image.
20. How does MRI work
MRI exploits the presence of vast amount of hydrogen in a
human body as the water content in human body is said to
be about 80%.
At the centre of each hydrogen atom is an even smaller
particle , called proton. Protons are like tiny magnets and
are very sensitive to magnetic fields and has magnetic spin.
MRI utilizes this magnetic spin properties of protons of
hydrogen to elicit images.
21. How does the MRI work
•The protons i.e. hydrogen ions in a body are spinning in a haphazard
fashion and cancel all the magnetism. That is our natural state.
•When there is large magnetic field acts on our body, protons in our body
line up in •same direction. •In same way that magnet can pull the needle
of a compass
22. Human body is largely made of water molecules, which
consists of smaller particles i.e hydrogen and oxygen atoms.
Protons lies at the Centre of each atom, which is sensitive to
any magnetic fields and hence this proton serves as a
magnet. Normally water molecules in our body are
randomly arranged, but upon entering on the MRI scanner
first magnet causes body’s water molecules to align in one
direction and second magnet was then turned on and off in
a series of quick pulses, causing each hydrogen atom to
alter their alignment and quickly , switches back to their
original relaxed state, when switched off.
24. MRI Magnetic Coils
Inside the main magnet is a set of gradient coils for
changing the field along the X, Y and Z directions
required for imaging. Inside the gradient coils are the RF
coils producing the field B1 for rotating the spin by an
angle dictated by the pulse sequence. These coils also
detect the signal emitted by the spins inside the body. At
the centre is a patient table which is computer
controlled.
The magnet, the RF body coil and the gradient coil
assembly represent the three major subsystems that
comprise the resonance module of the MR scanner.
29. COMPONETS OF MRI
1.Superconducting magnet
A superconducting magnet is the heart
and most expensive part of an MRI
scanner.
In its superconducting state, the wire has
no electrical resistance and therefore can
conduct much larger electric currents than
ordinary wire, creating intense magnetic
fields. ...
30. .Gradient coils
Gradient coils are used to produce deliberate variations in the main
magnetic field.
There are usually three sets of gradient coils, one for
each direction.
The variation in the magnetic field permits localization of
image slices as well as phase encoding and frequency
encoding.
The set of gradient coils for the z axis are Helmholtz
pairs, and for the x and y axis paired saddle coils.
31. COMPONETS OF MRI
Gradient coils
X coil – create a varying magnetic field from left
to right.
Y coil- create a varying magnetic field from top to
bottom.
Z coil- create a varying Magnetic field from head to toe
33. Radiofrequency RF Coils
3. RF Coils
Same as Radio waves – high wavelength, low energy
electromagnetic waves.
RF coils are the "antenna" of the MRI system
That transmits the RF signal and receives the return signal.
They are simply a loop of wire either circular or
rectangular.
inside the gradient, coils are the RF coils producing the field B for
rotating the spin by an angle dictated by the pulse sequence. These
coils also detect the signal emitted by the spins inside the body.At
the centre is a patient table which is computer controlled.
34.
35. COMPONENTS OF MRI 3.RF CoilsStart RF pulses (Excitation- Protons jump to
higher energy state by absorbing radiation).
36. 3.
RF coils Stop RF pulses (Relaxation- Protons
return to their original state emitting
radiation)
38. Computer System
Receives RF signal and performs analog to digital conversion.Digital
signal representing image of body part is stored in temporary image space
or case space. It store digital signal during data acquisition, digital signal
then sent to an image processor were a mathematical formula called
Fourier transformation is applied to image of MRI scan is displayed on a
monitor.