Lipid metabolism involves the breakdown of fats into fatty acids to produce energy or the synthesis of new lipids from smaller molecules. Fats can be obtained from food or synthesized in the liver or adipose tissue. Lipids are stored as triglycerides in adipose tissue and mobilized for energy through lipolysis. The liver plays a key role in lipid metabolism by breaking down fats and producing energy, cholesterol, and phospholipids. Lipids are essential for many bodily functions when consumed in proper amounts.
Lipid metabolism is the synthesis and degradation of lipids in cells.
It involves the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
In animals, these fats are obtained from food or synthesized by the liver.
Lipid metabolism is the synthesis and degradation of lipids in cells.
It involves the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
In animals, these fats are obtained from food or synthesized by the liver.
Lipid metabolism entails the oxidation of fatty acids to either generate energy or synthesize new lipids from smaller constituent molecules. Lipid metabolism is associated with carbohydrate metabolism, as products of glucose (such as acetyl CoA) can be converted into lipids.
Lipid metabolism entails the oxidation of fatty acids to either generate energy or synthesize new lipids from smaller constituent molecules. Lipid metabolism is associated with carbohydrate metabolism,
Lipids are fats that are either absorbed from food or synthesized by the liver. Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important.
Cholesterol is a ubiquitous constituent of cell membranes, steroids, bile acids, and signaling molecules.
Triglycerides primarily store energy in adipocytes and muscle cells.
Lipoproteins are hydrophilic, spherical structures that possess surface proteins (apoproteins, or apolipoproteins) that are cofactors and ligands for lipid-processing enzymes (see table Major Apoproteins and Enzymes Important to Lipid Metabolism). All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. Lipoproteins are classified by size and density (defined as the ratio of lipid to protein) and are important because high levels of low-density lipoproteins (LDL) and low levels of high-density lipoproteins (HDL) are major risk factors for atherosclerotic heart disease.
Dyslipidemia is elevation of plasma cholesterol and/or triglycerides, or a low HDL cholesterol level that contributes to the development of atherosclerosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. LIPID METABOLISM
Fats (or triglycerides) within
the body are ingested as
food or synthesized by
adipocytes or hepatocytes
from carbohydrate
precursors.
entails the oxidation of fatty
acids to either generate
energy or synthesize new
lipids from smaller
constituent molecules.
associated with
carbohydrate metabolism,
as products of glucose
(such as acetyl CoA) can be
converted into lipids.
3. WHAT IS THE DEFINITION OF LIPID
METABOLISM?
Lipid metabolism is the synthesis and
degradation of lipids in cells, involving
the break down or storage of fats for
energy. These fats are obtained from
consuming food and absorbing them
or they are synthesized by an animal's
liver.
4. WHAT IS THE END PRODUCT OF LIPID
METABOLISM?
Just like glucose, the end-products of
fatty acid metabolism are carbon
dioxide, water and ATP.
5. WHERE DOES LIPID METABOLISM OCCUR IN
THE BODY?
Triglycerides and lipids, high-energy
molecules, are stored in adipose
tissue until they are needed.
6. WHAT IS A LIPID METABOLISM DISORDER?
Lipid metabolism disorders, such as
Gaucher disease and Tay-Sachs
disease, involve lipids.
Lipids are fats or fat-like substances.
They include oils, fatty acids, waxes,
and cholesterol. ... Or the enzymes
may not work properly and your body
can't convert the fats into energy.
7. WHERE ARE LIPIDS STORED IN THE BODY?
Lipids such as cholesterol, cholesteryl
esters and triglycerides are stored in
your body primarily in specialized fat
cells called adipocytes, which
comprise a specialized fatty tissue
called adipose tissue.
Stored lipids can be derived from the
lipids in your diet or from lipids that
your body synthesizes.
8. WHAT IS THE ROLE OF THE LIVER IN THE USE
OF LIPIDS?
With the help of vitamin K, the liver
produces proteins that are important in
blood clotting.
In fat metabolism the liver cells break
down fats and produce energy.
9. HOW ARE LIPIDS USED IN THE BODY?
Lipids, also known as fats, play many
important roles in your body, from
providing energy to producing
hormones. You wouldn't be able to
digest and absorb food properly
without lipids. Of course, eating more
fat than you need can lead to weight
gain, but in proper amounts lipids are
a healthy part of your diet.
10. HOW DO WE METABOLIZE FAT?
Fat Metabolism. Almost all fat in your
diet comes in the form of triglycerides.
These compounds contain three fatty
acids held together by a molecule
called glycerol. In order to store or use
fats for energy, this bond must be
broken by pancreatic enzymes
released into your stomach acid.
11. WHAT HAPPENS TO FATTY ACIDS IN THE
LIVER?
The liver is the major site for
converting excess carbohydrates and
proteins into fatty acids and
triglyceride, which are then exported
and stored in adipose tissue. The liver
synthesizes large quantities of
cholesterol and phospholipids.
12. WHERE ARE LIPIDS ABSORBED IN THE BODY?
Most lipids that you consume in your
diet are fats. Some digestion occurs in
your mouth and the stomach, but most
takes place in the small intestine.
15. LIVER
The liver takes up a
large fraction of the fatty
acids. There they are in
part resynthesized into
triglycerides and are
transported in VLDL
lipoproteins to muscle
and other tissues.
16. CHOLESTEROL
Cholesterol is a waxy, fat-
like substance that's
found in all the cells in
your body. Your body
needs some cholesterol
to make hormones,
vitamin D, and
substances that help you
digest foods. Your body
makes all the cholesterol
it needs. Cholesterol is
also found in foods from
animal sources, such as
egg yolks, meat, and
cheese.
17.
18. HDL : GOOD CHOLESTEROL
High-density
lipoprotein
one of the five major
groups of lipoproteins.
Lipoproteins are
complex particles
composed of multiple
proteins which
transport all fat
molecules around the
body within the water
outside cells.
19.
20. LDL: BAD CHOLESTEROL
stands for low-
density
lipoproteins.
is called the "bad"
cholesterol
because a high
LDL level leads to a
buildup of
cholesterol in your
arteries.
21. VLDL : VERY LOW-DENSITY LIPOPROTEIN.
very low-density
lipoprotein.
also a "bad" cholesterol
because it too
contributes to the
buildup of plaque in
your arteries. But VLDL
and LDL are different;
VLDL carries
triglycerides and LDL
carries cholesterol.
22. FATTY ACID METABOLISM
Fatty acid
metabolism consists
of catabolic
processes that
generate energy, and
anabolic processes
that create
biologically important
molecules. Fatty
acids are a family of
molecules classified
within the lipid
macronutrient class.
23. FATTY ACID SYNTHESIS
Fatty acid synthesis is
the creation of fatty acids
from acetyl-CoA and
NADPH through the
action of enzymes called
fatty acid synthases.
This process takes place
in the cytoplasm of the
cell. Most of the acetyl-
CoA which is converted
into fatty acids is derived
from carbohydrates via
the glycolytic pathway.
24.
25. LIPOGENESIS
Lipogenesis is the
process your body
uses to convert
carbohydrates into
fatty acids, which
are the building
blocks of fats.
Fat is an efficient
way for your body
to store energy.
26. LIPOLYSIS
the breakdown of
lipids and involves
hydrolysis of
triglycerides into
glycerol and free
fatty acids.
Predominantly
occurring in adipose
tissue, lipolysis is
used to mobilize
stored energy
during fasting or
exercise.
27. PUTTING LIPIDS TO USE
essential to good health, not only for humans but also
for other animals and even plants.
a poor conductor of heat, lipids also can function as
effective insulators
Act as chemical messengers in the body, while others
serve as storage areas for chemical energy. There is a
good reason why babies are born with "baby fat" and
why children entering puberty often tend to become
chubby: in both cases, they are building up energy
reserves for the great metabolic hurdles that lie ahead,
and within a few years, they will have used up those
excessive fat stores