Leptospirosis is a bacterial disease that can infect humans and animals. It is caused by pathogenic Leptospira bacteria carried by rodents and other wild and domestic animals like cattle. In cattle, it is usually caused by Leptospira hardjo or Leptospira pomona which infect the kidneys and genital tract. The bacteria can be transmitted through contact with infected urine and survives best in warm, moist environments. Clinical signs in infected cattle include fever, anemia, and jaundice. Vaccination and improving sanitation can help prevent the spread of leptospirosis.
The new virus has made the jump from pigs to humans and has demonstrated it can also pass from human to human. This is why it is demanding so much attention from health authorities. The virus passes from human to human like other types of flu, either through coughing, sneezing, or by touching infected surfaces, although little is known about how the virus acts on humans.
The new virus has made the jump from pigs to humans and has demonstrated it can also pass from human to human. This is why it is demanding so much attention from health authorities. The virus passes from human to human like other types of flu, either through coughing, sneezing, or by touching infected surfaces, although little is known about how the virus acts on humans.
Leptospirosis is a worldwide public health problem. In humid tropical and subtropical areas, where most developing
countries are found, it is a greater problem than in those with a temperate climate. The magnitude of the problem in
tropical and subtropical regions can be largely attributed to climatic and environmental conditions but also to the
great likelihood of contact with a Leptospira-contaminated environment caused by, for example, local agricultural
practices and poor housing and waste disposal, all of which give rise to many sources of infection. In countries with
temperate climates, in addition to locally acquired leptospirosis, the disease may also be acquired by travellers
abroad, and particularly by those visiting the tropics.
Leptospirosis is a potentially serious but treatable disease. Its symptoms may mimic those of a number of other
unrelated infections such as influenza, meningitis, hepatitis, dengue or viral haemorrhagic fevers. Some of these
infections, in particular dengue, may give rise to large epidemics, and cases of leptospirosis that occur during such
epidemics may be overlooked. For this reason, it is important to distinguish leptospirosis from dengue and viral
haemorrhagic fevers, etc. in patients acquiring infections in countries where these diseases are endemic. At present,
this is still difficult, but new developments may reduce the technical problems in the near future. It is necessary,
therefore, to increase awareness and knowledge of leptospirosis as a public health threat.
Leptospirosis is a worldwide public health problem. In humid tropical and subtropical areas, where most developing
countries are found, it is a greater problem than in those with a temperate climate. The magnitude of the problem in
tropical and subtropical regions can be largely attributed to climatic and environmental conditions but also to the
great likelihood of contact with a Leptospira-contaminated environment caused by, for example, local agricultural
practices and poor housing and waste disposal, all of which give rise to many sources of infection. In countries with
temperate climates, in addition to locally acquired leptospirosis, the disease may also be acquired by travellers
abroad, and particularly by those visiting the tropics.
Leptospirosis is a potentially serious but treatable disease. Its symptoms may mimic those of a number of other
unrelated infections such as influenza, meningitis, hepatitis, dengue or viral haemorrhagic fevers. Some of these
infections, in particular dengue, may give rise to large epidemics, and cases of leptospirosis that occur during such
epidemics may be overlooked. For this reason, it is important to distinguish leptospirosis from dengue and viral
haemorrhagic fevers, etc. in patients acquiring infections in countries where these diseases are endemic. At present,
this is still difficult, but new developments may reduce the technical problems in the near future. It is necessary,
therefore, to increase awareness and knowledge of leptospirosis as a public health threat.
THIS VIDEO EXPLAINS ABOUT LEPTOSPIROSIS IN EASY WAY Important links- NOTES- https://mynursingstudents.blogspot.com/ youtube channel https://www.youtube.com/c/MYSTUDENTSU... CHANEL PLAYLIST- ANATOMY AND PHYSIOLOGY-https://www.youtube.com/playlist?list... COMMUNITY HEALTH NURSING- https://www.youtube.com/playlist?list... CHILD HEALTH NURSING- https://www.youtube.com/playlist?list... FIRST AID- https://www.youtube.com/playlist?list... HCM- https://www.youtube.com/playlist?list... FUNDAMENTALS OF NURSING- https://www.youtube.com/playlist?list... COMMUNICABLE DISEASES- https://www.youtube.com/playlist?list... ENVIRONMENTAL HEALTH- https://www.youtube.com/playlist?list... MSN- https://www.youtube.com/playlist?list... HINDI ONLY- https://www.youtube.com/playlist?list... ENGLISH ONLY- https://www.youtube.com/playlist?list... facebook profile- https://www.facebook.com/suresh.kr.lrhs/ FACEBOOK PAGE- https://www.facebook.com/My-Student-S... facebook group NURSING NOTES- https://www.facebook.com/groups/24139... FOR MAKING EASY NOTES YOU CAN ALSO VISIT MY BLOG – BLOGGER- https://mynursingstudents.blogspot.com/ Instagram- https://www.instagram.com/mystudentsu... Twitter- https://twitter.com/student_system?s=08 #LEPTOSPIROSIS,#FUNCTIONS,#SOURCE, #DEFICIENCY,#DISEASE,#NIGHTBLINDNESS#XEROPHTHALMIA,#BITOTSPOT,#CORNEALXEROSIS, #CONJUNCIVALXEROSIS, YELLOWFRUITS,#MYSTUDENTSUPPORTSYSTEM, #rashes,#nursingclasses, #communityhealthnursing,#ANM, #GNM, #BSCNURING,#NURSINGSTUDENTS, #WHO,#NURSINGINSTITUTION,#COLLEGEOFNURSING,#nursingofficer,#COMMUNITYHEALTHOFFICER
Important Zoonotic disease and its prevention and control By: Dr.Manoj karkimanojj123
Zoonosis are those disease and infection which are naturally transmitted between animals and human. (WHO & FAO, 1959).
Zoonosis word derived from Greek word “ZOO” means Animals and “NOSES” means Disease.
One Health is not a new concept, but it has become more important in recent years because many factors have changed the interaction among human, animals and the environment. These changes have caused the emergence and re-emergence of many disease.
Leptospirosis: Its Epidemiology, Diagnosis and Control Chandrani Goswami
Leptospirosis is a zoonosis caused by pathogenic spirochetes of the genus Leptospira.
Disease was first described by Adolf Weil in 1886
In 1908, a Japanese research group led by Ryokichi Inada and Yutaka to first identified the bacterium as the causative agent of leptospirosis and noted its presence in rats in 1916
Generally it is transmitted by the infected urine of rodents.
Leptospirosis is in the group of 17 neglected tropical diseases, categorized by WHO.
Leptospirosis is an underreported disease, and there are no reliable global incidence figures (WHO, 2015)
Synonyms: Weil's Syndrome, Weil-Vasiliev disease, Swineherd's disease, Rice-field fever, Waterborne fever, Nanukayami fever, Cane-cutter fever, Swamp fever, Mud fever, Stuttgart disease, and Canicola fever.
Infections spread from animals to human are called zoonotic infections.
The term zoonos is’ Derived from the Greek
ZOON (animals) and NOSES (diseases)
Pathogens shared with wild or domestic animals cause more than 60% of infectious diseases in man.
Rabies its transmission, clinical features and preventionmanojj123
Many people think that rabies is transmitted through only dog. But its not true, rabies is transmitted through not only dog, but also spread through bite or scratch from rabies infected animal like dog, bats, raccons, fox, monkeys etc.. Any open wound exposed saliva of infected animal can be potential source of infection.
Many European countries and North America have already eliminated rabies as a public health problem through mandatory vaccination of dog and good access to post exposure prophylaxis for human beings.
More than 95% of human death occurs in Asia/ Africa. And 99% of human rabies cases came from dogs. There is a small proportion of human rabies reported due to transmission via wild life (such as fox, wolves, jackels, raccoon, bats). Rabies kills more than 60,000 people each year (that is one death in every 9 minute) over 150 countries.
Cutaneous anthrax is the most common form of anthrax infection, and it is also considered to be the least dangerous. Infection usually develops from 1 to 7 days after exposure.
When anthrax spores get into the skin, usually through a cut or scrape, a person can develop cutaneous anthrax.
Zoonoses :- derived from the Greek words
Zoon- Animal & Noson – Disease
Zoonoses was coined and first used by Rudolf Virchow who defined it for communicable diseases.
Diseases and infections which are naturally transmitted between vertebrate animals and humans - WHO 1959
Of the 1415 microbial diseases affecting humans, 61% are zoonotic with 13% species regarded as emerging or reemerging
Link b/w human & animals with their surrounding are very close especially in developing countries
Nematodes are invertebrate roundworms that inhabit marine, freshwater, and terrestrial environments. They comprise the phylum Nematoda (or Nemata) which includes parasites of plants and of animals, including humans, as well as species that feed on bacteria, fungi, algae, and on other nematodes. Four out of every five multicellular animals on the planet are nematodes (Platt, 1994). Cobb (1914) calculated that if the nematodes resident in a single acre of soil near San Antonio, Texas, USA, were to proceed in head-to-tail procession to Washington D.C., some 2000 miles away, the first nematode would reach Washington before the rear of the procession left San Antonio!
Ghost Worms in the Sky
Lyrics: Kathy Merrifield
Vocals: Pointless Sisters
The majority of nematodes are microscopic, averaging less than a millimeter in length, but some of the animal parasites are quite large and readily visible to the naked eye. The animal and plant parasites are of direct importance in agriculture, the environment, and in human health; however, most nematodes in the environment are not parasites. Nematodes that feed on other organisms are important participants in the cycling of minerals and nutrients in the ecosystem that is fundamental to other biological activity. Some of these nematodes may have major roles in decomposition, including biodegradation of toxic compounds. In fact, the incidence of certain nematode species is sometimes used as an indicator of environmental quality. Insect-parasitic nematodes can be of importance in regulating insect populations, and are being used in the biological control of insect pests.
The developmental biology of one nematode species, Caenorhabditis elegans, is better characterized than that of any other multicellular organism. C. elegans is studied as a model system in molecular and developmental biology, and is providing insights into many other areas of biology and medicine.
Food hygiene is more than cleanliness ......
Protecting food from risk of contamination, including harmful bacteria, poison and other foreign bodies.
Preventing any bacteria present multiplying to an extent which would result in the illness of consumers or the early spoilage of the food.
Destroying any harmful bacteria in the food by thorough cooking
or processing.
Discarding unfit or contaminated food.
T-Cell Activation
• Concept of immune response
• T cell-mediated immune response
• B cell-mediated immune response
I. Concept of immune response
• A collective and coordinated response to the introduction of foreign substances in an individual mediated by the cells and molecules in the immune system.
II. T cell-mediated immune response
• Cell-mediated immunity is the arm of the adaptive immune response whose role is to combat infection of intracellular pathogens, such as intracellular bacteria (mycobacteria, listeria monocytogens), viruses, protozoa, etc.
Major Histocompatibility Complex
MHC:
• Major Histocompatibility Complex
– Cluster of genes found in all mammals
– Its products play role in discriminating self/non-self
– Participant in both humoral and cell-mediated immunity
• MHC Act As Antigen Presenting Structures
• In Human MHC Is Found On Chromosome 6
– Referred to as HLA complex
• In Mice MHC Is Found On Chromosome 17
– Referred to as H-2 complex
• Genes Of MHC Organized In 3 Classes
– Class I MHC genes
• Glycoproteins expressed on all nucleated cells
• Major function to present processed Ags to TC
– Class II MHC genes
• Glycoproteins expressed on macrophages, B-cells, DCs
• Major function to present processed Ags to TH
– Class III MHC genes
• Products that include secreted proteins that have immune functions. Ex. Complement system, inflammatory molecules
Antigen Processing and Presentation MID
Antigens and “foreignness”
• Antigens (or, more properly, immunogens) have a series of features which confer immunogenicity.
• One of these features is “foreignness.”
• So, we can infer that – most often – antigens – ultimately – originate externally.
• (There are exceptions, of course. Some cells become transformed by disease [e. g., cancer] or by aging. In such instances, the antigens have an internal origin.)
Extinction of a particular animal or plant species occurs when there are no more individuals of that species alive anywhere in the world - the species has died out. This is a natural part of evolution. But sometimes extinctions happen at a much faster rate than usual. Natural Causes of Extinction.
Difference between In-Situ and Ex-Situ conservation
Conservation of biodiversity and genetic resources helps protect, maintain and recover endangered animal and plant species. There are mainly two strategies for the conservation of wildlife: In-situ conservation and Ex-situ conservation. Although, both the strategies aim to maintain and recover endangered species, they are different from each other. Let us see how they differ from each other!
Evolution Of Bacteria
Bacteria have existed from very early in the history of life on Earth. Bacteria fossils discovered in rocks date from at least the Devonian Period (419.2 million to 358.9 million years ago), and there are convincing arguments that bacteria have been present since early Precambrian time, about 3.5 billion years ago. Bacteria were widespread on Earth at least since the latter part of the Paleoproterozoic, roughly 1.8 billion years ago, when oxygen appeared in the atmosphere as a result of the action of the cyanobacteria. Bacteria have thus had plenty of time to adapt to their environments and to have given rise to numerous descendant forms.
Impact of Environment on Loss of Genetic Diversity and Speciation
Genetic variation describes naturally occurring genetic differences among individuals of the same species. This variation permits flexibility and survival of a population in the face of changing environmental circumstances. Consequently, genetic variation is often considered an advantage, as it is a form of preparation for the unexpected. But how does genetic variation increase or decrease? And what effect do fluctuations in genetic variation have on populations over time?
GENE ENVIRONMENT INTERACTION
Subtle differences in one person’s genes can cause them to respond differently to the same environmental exposure as another person. As a result, some people may develop a disease after being exposed to something in the environment while others may not.
As scientists learn more about the connection between genes and the environment, they pursue new approaches for preventing and treating disease that consider individual genetic codes.
How to store food in hot
The Good News
To maximize benefit of preservation, keep your food as fresh as possible for as long as possible. You can do this, even in the heat, by creating a “cooler” made from two basic terra cotta pots, one larger than the other. Put the smaller pot in the larger one, fill the gap with sand, and saturate the sand with water. Then cover it with a cloth. To add additional insulation from the heat, bury the pot up to its rim. The evaporation of moisture from the wet sand will cool the air around the food and help keep it fresh.
What is IUPAC naming?
In order to give compounds a name, certain rules must be followed. When naming organic compounds, the IUPAC (International Union of Pure and Applied Chemistry) nomenclature (naming scheme) is used. This is to give consistency to the names. It also enables every compound to have a unique name, which is not possible with the common names used (for example in industry). We will first look at some of the steps that need to be followed when naming a compound, and then try to apply these rules to some specific examples.
IUPAC Nomenclature
IUPAC nomenclature uses the longest continuous chain of carbon atoms to determine the basic root name of the compound. The root name is then modified due to the presence of different functional groups which replace hydrogen or carbon atoms in the parent structure.
Hybridization describes the bonding atoms from an atom's point of view. For a tetrahedral coordinated carbon (e.g. methane CH4), the carbon should have 4 orbitals with the correct symmetry to bond to the 4 hydrogen atoms.
INTRODUCTION:
Hybrid Orbitals
Developed by Linus Pauling, the concept of hybrid orbitals was a theory created to explain the structures of molecules in space. The theory consists of combining atomic orbitals (ex: s,p,d,f) into new hybrid orbitals (ex: sp, sp2, sp3).
1. Why Firefly give light during night?
2. Why atomic mass and Atomic numbers are given to elements ?
3. Why elements have been characterized and classified into different groups?
4. What is the transition of elements and what they play their role in elements stability?
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. 1
Amjad Khan Afridi 3th
March , 2017
Leptospirosis
Introduction
Leptospirosis is a bacterial disease that affects farm animals, wildlife and humans.
There are many different strains or serovars, carried by rodents and many other wild animals
including rabbits, skunks and birds. Cattle, pigs and dogs are the main domestic animal carriers
of leptospirosis.
Leptospirosis in cattle is generally caused by one of two strains: Leptospira hardjo or Leptospira
Pomona. These two bacteria infect the kidney and genital tract of cattle.
Causative Agent
Leptospirosis is primarily a disease of animals, occasionally infect humans. It is caused by
pathogenic spirochete of the genus leptospira that traditionally consist of two species, Leptospira
interrogans and Leptospira biflexa. The former includes all pathogenic serovars and the later
includes the saprophytic strains. Leptospira strains have been divided into 26 serogroups, of
which 2 belong to saprophytic leptospires.
Each serogroup consists of several strains designated as seorovars. Nearly 300 host adopted
leptospiral serovars are naturally carried by more than a dozen species of rodents, wild and
domestic animals. The moderate to highly conducive abundantly available variety of hosts,
results in successful perpetuation of this organism. The leptospira serovars predominantly
present in India are L.andamana, L.pomona, L.grippotyphosa, L.hebdomadis, L.semoranga,
L.javanica, L.autumnalis, L.canicola.
Pathogenesis
Leptospira enter the body through exposed mucous membranes in the mouth, eyes, skin
abrasions or gastrointestinal tract. The incubation period for leptospirosis is 4 to 20 days. The
leptospires circulate in the blood for 7 days. The leptospires replicate in the liver, kidneys, lungs,
genital tract and central nervous system. The bacteria remain in the kidneys and may be shed in
the urine for a few weeks to many months after infection.
Clinical signs
Leptospirosis is less common in cattle under 15 months of age than in older animals. The clinical
signs of infected calves include;
High fever
Hemolytic anemia (breakdown of red blood cells)
Hemoglobinuria (blood/hemoglobin in urine)
2. 2
Amjad Khan Afridi 3th
March , 2017
Jaundice (yellowing of tissues)
Meningitis and death.
Myalgia
Headache
Conjuctival suffusion
Oliguria/Anuria and/or proteinuria
Nausea
vomiting
Abdominal pain
Diagnosis
Serological evaluation of a herd or pen can infer antibody production against leptospira. Urine
can be tested using dark-field microscopy and/or immunofluorescence. However, these tests are
expensive and the dark-field microscopy isn’t very sensitive. The gold standard is bacterial
culture. Leptospira can be isolated from blood, urine, kidney, liver or any other tissue infected by
the bacteria.
Transmission
Transmission of leptospira often involves direct contact with infected urine, placenta or milk. It
can be transmitted venereally or transplacentally. The most common transmission is through
direct or indirect contact with infected urine. Dairies commonly have leptospira contaminations
in their environment. Dairy feeder calves are probably the largest carriers of leptospira in
commercial feedyards. Dairy calves commonly suckle the sheaths and scrotums of other calves
in the pen. This would be a direct contamination of infected urine from carriers by this suckling
habit.
Leptospira can also survive in the environment. Leptospira favors moist environments and
moderately warm temperatures. Leptospira can survive for extended periods in stagnant water
(i.e. waterholes in pens). Survival of leptospiral is brief in dry soil, cold temperatures or very hot
temperatures. Therefore leptospira outbreaks are most common in dairy calves in the fall and
spring.
Factors Responsible ForThe Emergence OfLeptospirosis
The conditions that are favourable for maintenance and transmission of Leptospirosis are:
a) Reservoir and carrier hosts
Leptospirosis has a very wide range of natural rodent, and non-rodent reservoir hosts especially
rats, cattle, dogs, foxes, rabbits, etc. The animals act as carriers of the leptospires and excrete
3. 3
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large number of leptospires in their urine, thus responsible for the contamination of large and
small water bodies as well as soil.
b) Flooding, drainage congestion
Flooding and drainage congestion may be risk factors for contamination of water bodies with
infected animal urine. Water logged areas may force rodent population to abandon their burrows
and contaminate the stagnant water by their urine.
c) Animal-Human Interface
The potential for infection increases through exposure from occupational or recreational
activities without proper protection. Poor cleanliness/sanitation in recreational areas may attract
animal host such as rodent thus increases the risk of contamination. These may be due to poor
maintenance of facilities, improper disposal of waste and public attitude/ apathy.
d) Human host risk factors
Several sections of the population are more susceptible to infection such as those not previously
exposed to the bacteria in their environment (naïve immunities), and those with chronic disease
and open skin wounds.
HIGH RISK GROUPS
Exposure depends on chance contacts between human and infected animals or a contaminated
environment through occupational and/or recreational activities. Some groups are at higher risk
to contract the disease such as:
Workers in the agricultural sectors
Sewerage workers
Livestock handlers
Pet shops workers
Military personnel
Search and rescue workers in high risk environment
Disaster relief workers (e.g. during floods)
People involved with outdoor/recreational activities such as water recreational activities,
jungle trekking, etc.
Travelers who are not previously exposed to the bacteria in their environment especially
those travelers and/or participants in jungle adventure trips or outdoor sport activities
People with chronic disease and open skin wounds.
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Treatment
Leptospira is a bacterium that is susceptible to dihydrostreptomycin or long-acting
oxytetracycline. We are currently recommending a mass-treatment of the pen with Tetradure 300
at 5 cc/cwt subcutaneously. This new oxytetracycline has blood levels above MIC (minimum
inhibitory concentration) for eight days. Cattle should also be vaccinated with an IBR/Lepto
vaccine at the time of mass-treatment.
Prevention
There are two avenues of prevention for leptospirosis: 1) vaccination and 2) environmental
sanitation. Since dairy cattle are the highest risk for leptospirosis, we are recommending that all
dairy calves receive a leptospirosis vaccination upon arrival.
There are many different brands available and none seem to be better nor worse than the others.
Vaccination will not stop an infected animal from shedding the bacteria however it will help
reduce the infection of naïve calves. Environmentally, we need to be sure that we remove areas
of stagnant water in the feeding and hospital pens. Especially, if there are dairy calves in the pen.
For people who work with animals:
Cover cuts and abrasions with a waterproof dressing;
Wear protective clothing (for example, gloves, eye shields or goggles, aprons and boots)
when working with animals that could be infected, especially if there is a chance of
contact with urine;
Wear gloves when handling cattle placentas or stillborn or aborted calves or carcasses;
Shower after work and wash and dry hands after handling potentially infected material;
Do not eat or smoke while handling animals that may be infected. Wash and dry hands
before smoking or eating;
Vaccinate livestock as recommended by your vet.
For other people:
Avoid swimming in water where there is a possibility of contamination with animal
urine.
Cover cuts and abrasions with waterproof dressings, especially before coming into
contact with soil, mud or water that may be contaminated with animal urine.
Wear footwear outdoors, especially when walking in mud or moist soil.
Wear gloves when gardening.
Control rodents by cleaning up rubbish and removing food sources that are close to
housing.
Do not feed raw offal to dogs.
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Zoonosis
Leptospirosis is a human pathogen. The bacteria can get into your body through cuts and
scratches, the lining of your mouth, throat and eyes after contact with infected urine, blood or
contaminated water. Care should be taken when necropsying animals suspected of being infected
with leptospira.
How can we prevent exposure?
1) Cover all cuts and broken skin before and during work
2) Wear protective clothing and eyewear when necropsying
3) Wash you hands after handling any animal before eating, drinking, smoking, dipping, or
chewing tobacco.
Human clinical signs of leptospirosis:
1) fever and flu like symptoms
2) lethargy, aching joints, headaches
3) long period of sickness with the potential for renal failure.
Amjad Khan Afrid
3th
March , 2017