Zoonosis are those disease and infection which are naturally transmitted between animals and human. (WHO & FAO, 1959).
Zoonosis word derived from Greek word “ZOO” means Animals and “NOSES” means Disease.
One Health is not a new concept, but it has become more important in recent years because many factors have changed the interaction among human, animals and the environment. These changes have caused the emergence and re-emergence of many disease.
Zoonoses :- derived from the Greek words
Zoon- Animal & Noson – Disease
Zoonoses was coined and first used by Rudolf Virchow who defined it for communicable diseases.
Diseases and infections which are naturally transmitted between vertebrate animals and humans - WHO 1959
Of the 1415 microbial diseases affecting humans, 61% are zoonotic with 13% species regarded as emerging or reemerging
Link b/w human & animals with their surrounding are very close especially in developing countries
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
Zoonoses :- derived from the Greek words
Zoon- Animal & Noson – Disease
Zoonoses was coined and first used by Rudolf Virchow who defined it for communicable diseases.
Diseases and infections which are naturally transmitted between vertebrate animals and humans - WHO 1959
Of the 1415 microbial diseases affecting humans, 61% are zoonotic with 13% species regarded as emerging or reemerging
Link b/w human & animals with their surrounding are very close especially in developing countries
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Brucellosis is an important re-emerging zoonosis with a worldwide distribution, in India was recognised first in 1942.
It is still an uncontrolled serious public health problem in many developing countries including India. Brucellosis in India is yet a very common but often neglected disease.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Rabies its transmission, clinical features and preventionmanojj123
Many people think that rabies is transmitted through only dog. But its not true, rabies is transmitted through not only dog, but also spread through bite or scratch from rabies infected animal like dog, bats, raccons, fox, monkeys etc.. Any open wound exposed saliva of infected animal can be potential source of infection.
Many European countries and North America have already eliminated rabies as a public health problem through mandatory vaccination of dog and good access to post exposure prophylaxis for human beings.
More than 95% of human death occurs in Asia/ Africa. And 99% of human rabies cases came from dogs. There is a small proportion of human rabies reported due to transmission via wild life (such as fox, wolves, jackels, raccoon, bats). Rabies kills more than 60,000 people each year (that is one death in every 9 minute) over 150 countries.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Brucellosis is an important re-emerging zoonosis with a worldwide distribution, in India was recognised first in 1942.
It is still an uncontrolled serious public health problem in many developing countries including India. Brucellosis in India is yet a very common but often neglected disease.
Presented by Hung Nguyen-Viet and Jakob Zinsstag at a technical workshop of the Food and Agriculture Organization of the United Nations (FAO) regional initiative on One Health, Bangkok, Thailand, 11–13 October 2017.
Rabies its transmission, clinical features and preventionmanojj123
Many people think that rabies is transmitted through only dog. But its not true, rabies is transmitted through not only dog, but also spread through bite or scratch from rabies infected animal like dog, bats, raccons, fox, monkeys etc.. Any open wound exposed saliva of infected animal can be potential source of infection.
Many European countries and North America have already eliminated rabies as a public health problem through mandatory vaccination of dog and good access to post exposure prophylaxis for human beings.
More than 95% of human death occurs in Asia/ Africa. And 99% of human rabies cases came from dogs. There is a small proportion of human rabies reported due to transmission via wild life (such as fox, wolves, jackels, raccoon, bats). Rabies kills more than 60,000 people each year (that is one death in every 9 minute) over 150 countries.
Peste des-ruminants-is-a-rinderpest.doc pdfGudyne Wafubwa
Peste des petits ruminant virus (PPRV) is a disease mostly affecting goats and sheep. Since its first discovery, it has caused massive economic loss to most small pastoralists in Africa and other developing countries. It is the integral role of all stakeholders to join hands so as to eradicate the disease.
Can humans be ill from dogs?
The short answer is yes, they can.
Diseases that can spread from humans to animal species are called Zoonotic illnesses. They are distributed through wild or farm pets that are kept as household items, such as dogs and cats. Infectious germs can be spread easily through pets at home, per the 2015 research conducted by Trusted Source that ranges from stomach bugs, diarrhea, and minor skin irritations to severe issues. The close contact humans have with their pets can be a perfect environment for spreading a bacterial infection, 2016 research suggests.
A research study from 2012 that was conducted in Finland confirms that noroviruses are among the leading causes of diarrheal disorders in all age groups, and they can be carried by dogs and transmitted to humans.
While infection and subsequent illness aren’t likely, dogs are carriers of germs that could cause disease in people. The spread of these illnesses and germs from dogs in these ways:
They can be spread through food items, other treats, water containers, or surfaces.
Pick the poop of your dog and then place your hands on your eyes or mouth.
The dog that lick your face using their tongues can carry an infection.
You share the same bedding as your pet.
The dog you love gives you scratches, cuts, or bites that tear the skin.
Rabies: A Deadly Threat
Rabies is a viral disease that affects the central nervous system and is typically transmitted through the bite of an infected animal. While rabies in domesticated dogs is rare in many countries due to vaccination protocols, ensuring your dog’s vaccination is current is crucial. Additionally, in case of any unusual behavior or symptoms in your dog, such as aggression, excessive drooling, or difficulty walking, seeking immediate veterinary care is essential. Avoiding contact with stray animals and ensuring your dog is not exposed to potentially rabid wildlife can significantly mitigate the risk of contracting this fatal disease.
Addressing the Risk of Ringworm
Ringworm is a fungal infection that can be passed from dogs to humans through direct contact. This infection presents as circular, red, and itchy patches on the skin and can spread rapidly if not treated promptly. Maintaining good hygiene practices, such as regular hand washing after handling your dog and ensuring your dog’s skin is regularly checked for any signs of infection, is crucial in preventing the spread of ringworm. Prompt treatment from a healthcare professional is necessary if you suspect your dog has been infected with ringworm.
Preventing Leptospirosis Contamination
Leptospirosis is a bacterial disease that can be transmitted to humans through contact with infected animals’ urine or contaminated water. Dogs can contract leptospirosis through exposure to infected wildlife, such as rodents, or contaminated water sources. Preventative measures such as vaccination, avoiding stagnant water sources during walks, and maintaining a clean and hygienic living
zoonoses and its classification on basis of typesNabeel805998
This presentation contains a compression data on the Zoonosis, its types and classification. Along with it aslo contains data on bacterial and viral diseases that are zoonotic. There are terminologies related to epidemiology.
zoonoses and its classification on basis of typesNabeel805998
This presentation contains a compression data on the Zoonosis, its types and classification. Along with it aslo contains data on bacterial and viral diseases that are zoonotic. There are terminologies related to epidemiology.
Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.
Diagnosis of fungal disease by Dr. Manoj karkimanojj123
Early diagnosis of fungal infection is critical for effective treatment. History, clinical signs, gross pathology and in few cases intradermal skin test are all of the value in the diagnosis of clinical specimens.
Equine play an important role in rural communities providing power and transport at low cost. They can be used for various agricultural operations such as ploughing, planting and weeding. They also provide the much-needed transport in rural areas for activities such as carrying water, building materials, agricultural products and people.
Animal welfare refers to the relationship people have with animal and the duty they have to assure that the animal under their care are treated humanely and responsibly.
prevalence of fasciola hepatica in domesticated animal and its control and pr...manojj123
Fasciola hepatica also called (Liver fluke) is a parasitic disease caused by infection of trematode belongs to genus (F. hepatica, F. gigentica). Fasciola hepatica is distributed worldwide and cause great economic loss in livestock sector. Infected animal become anemic and loss of significant amount of weight.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Important Zoonotic disease and its prevention and control By: Dr.Manoj karki
1. Dr. Manoj Karki
M.V.Sc
Equine Field Officer
Durguali, Kailali
2021/8/4
Important Zoonotic Disease
Prevention and Control
Organization by:
2. INTRODUCTION:
Zoonosis are those disease and infection which are naturally
transmitted between animals and human. (WHO & FAO,
1959).
Zoonosis word derived from Greek word “ZOO” means
Animals and “NOSES” means Disease.
More than 200 zoonotic disease describe world wide.
Protecting yourself and your family from animal
diseases and infections.
3. At lease 61% of all human pathogen are zoonotic
75% of new disease discovered in last decade are also
zoonotic.
Animals can carry harmful germs, such as bacteria, virus,
fungi, parasite. These are shared with human and cause illness.
5. One Health is not a new concept, but it has become more
important in recent years because many factors have changed
the interaction among human, animals and the environment.
These changes have caused the emergence and re-emergence
of many disease.
6. FACTOR (CAUSE) CHANGE (EFFECT)
Human population are growing and
expanding into new geographic area
As a result more people live in close
contact with wild/ domestic animals.
Close contact provide more opportunities
for disease to pass between animals and
people.
The earth has experience change in
climate and land use, such as
deforestation and intensive farming
practice.
Disruption in environmental condition
and habitats provides new opportunities
for disease to pass to animals.
International travel, trades have
increased
As a result disease can spread quickly
across the globe
7. Who is at risk:
Veterinarian
Grooming
Horseman
Butchers
Lab work
Farmers
8. How they are transmitted
Zoonosis can be transmitted by various way.
9.
10. Transmission of zoonotic disease
Every day contact with animals
Transporting carcasses
By-products (feces/urine)
Scratches or bites
From milk and milking
Contaminated soils
Contaminated meats
Through insect bites like mosquitos or ticks
11. Factor Influencing the Emergence or re-emergence Zoonotic
Disease
Increased movement of traveling of man. Eg, amobiasis,
giardiasis, salmonella etc..
Handling animal by product and waste. Eg, Anthrax,
dermatophytosis
Increased trade in animals product. Eg, Anthrax, brucella,
salmonella bird flu..
Drug resistance organism. Eg, E- coli, staphylococcus aureus,
Changing environmental condition including climate and
disaster. Eg, plague, leptospirosis
13. Common zoonosis:
Japanese Encephalitis: Mosquito (culex tritaeniorhynchus)
born viral zoonotic disease of public health importance and high
mortality rate.
Family: Flaviviridae, most common cause of childhood viral
encephalitis in world.
Pig is the amplifier host. Bird and pig are most important
reservoir.
Through they usually do not manifest the disease, they develop
very high titers of virus and infect mosquitoes. These pig are
known as amplifying host.
14. Mode of spread:
Man or cattle get infected either from birds or pigs
through mosquito bite.
Man and man transmission does not occur in
Nature.
15. The virus enter in the brain and neurological cell through
hematogenous where it cause extensive damage to the brain
cell by mechanical means and inflammatory reaction.
Infected person show high fever, headache, prostration, nuchal
rigidity and altered sensorium.
In some case incoordination, paralysis and death occur in
extensive damage of neurological cells.
16.
17.
18. Rabies: Rabies is an acute viral zoonotic disease (a disease
that is transmitted to human from animal) characterized by sign
of abnormal behavior, nervous disturbance ascending paralysis
and death.
All warm blooded mammals are susceptible to infection by the
rabies virus.
The virus is present in the saliva of the infected animal and is
transmitted to the other animal and to human through saliva.
19. Rabies is caused by RNA virus belongs to family
Rhabdoviridae and genus lyssavirus.
20. Spread of rabies:
Rabies is transmitted through direct contact between the virus
(e.g. in contaminated saliva) and mucus membrane or wound.
Human infection most frequently occurs following a
transdermal bite or scratch from an infected animal.
Very rare, rabies has been contracted by inhalation of virus
containing aerosol (eg. In caves inhabited by bats)
21. Human –human transmission has never been confirmed.
With the exception of organ transplant from rabid
patient.
Transmission through the consumption of milk and
cooked meat has not been reported to date but the
consumption of milk and meat from rabid animal is
discouraged
22.
23.
24. More than 95% of human death occurs in Asia/ Africa. And
99% of human rabies cases came from dogs.
There is a small proportion of human rabies reported due to
transmission via wild life (such as fox, wolves, jackels,
raccoon, bats).
Rabies kills more than 60,000 people each year (that is one
death in every 9 minute) over 150 countries. Some countries
like Australia, Switzerland, Netherland, rabies are eliminated.
25. How virus travels:
Rabid dog virus enter through saliva Travel via
Peripheral Nervous System to Central Nervous System.
Many people think that rabies is transmitted through only dog.
But its not true, rabies is transmitted through not only dog, but
also spread through bite or scratch from rabies infected animal
like dog, bats, raccons, fox, monkeys etc.. Any open wound
exposed saliva of infected animal can be potential source of
infection.
26. Clinical findings:
In dog:
Furious form
This is classic “mad dog syndrome”. There is rarely evidence
of paralysis during this stage. This form can be divided into
stage of melancholy and stage of excitation.
Stage of melancholy: In this stage, dog may show bite
inanimate or animate objects. It may show unusual violence
and frenzy behavior. Rabid dog may move from one village to
other a long distance in a circular way and thus spread the
disease over wide areas.
27. The animal may lick water and attempt to drink but due to
obvious paralysis of pharyngeal and laryngeal muscle
does not succeed to drink water. The above period last for
1 to 3 days.
Stage of excitement: In this form dog may become very
aggressive. Dog may hide in dark place due to photophobia.
The voice may be change due to the paralysis of vocal cord.
Animal may lick their genital area its show that the sign of
heat.
28. In the fag end, the dog will lose its ability to bark. The lower
jaw will hang, tongue will protrude and head will drop
down.
The dog will develop dyspnea, ascending paralysis, coma
and death. This period may last for 1 to 7 days.
29. Dumb form:
This form is also called paralytic form. In this form there is
paralysis of lower jaw, tongue, larynx, and hind quarter.
The dog is unable to close the mouth (open mouth condition). In
fair percentage of cases, the owner is suspicious that a bone or
some other object might have stuck in the neck and owner may
try to open the mouth for examination and thus prone them to the
possibility of contracting the infection.
The entire clinical course of the disease up to the death takes 1 to
7 days.
30.
31. 10 day confinement and observation period:
Clinically course usually less than 7 days animal dead before
end of 10 days.
In general if a biting dog does not die within 10 days rabies is
unlikely.
In human:
Initial symptoms: pain or paraesthesia at the wound site
Later: hyperactivity, hallucination, hydrophobia, paralysis
and coma and death
32. Furious form:
Hydrophobia, photophobia, aerophobia
Excitation and confusion
Excessive sweating/ salivation’
Dehydration and death in 2 to 5 days
Paralytic form:
Gradual ascending paralysis
Hydrophobia is not seen
Coma, death in 1-2 weeks
33. Approximately 80% of patient present with classical
(furious) rabies and 20% present with paralytic rabies.
40 to 50% of people who are bitten by suspected rabid
animal are children under 15 years age. In Nepal less than
100 people have been died each year due to rabies.
Can we treat after appearance of symptoms?
No treatment of rabies after the appearance of symptoms.
Fatal after symptoms begin.
34. How long will it take to show symptoms in human?
Generally between 1 to 3 month to more than 1 year.. But it may be
short as 4 days or long or may be many years. It depends upon
location of bite and how deep the wound
Prevention and control:
Rabies in human can be prevented, after exposure by PEP. Proper
wound management combine with PEP is close to 100% effective in
preventing rabies.
Immunize all dog and cat owned by an individual or by the
community
Immunize any person with proven or probable exposure to rabies
and administer rabies immunoglobulin in case of severe exposure
35. Wild animal should not be kept as pets
Strict quarantine regulation
Human as high risk (eg. Veterinarian, vet technician, lab
person, volunteer, etc.. ) much received pre exposure
immunization.
Pre exposure prophylaxis : 0,7, 21 or 28 days
Post exposure prophylaxis:0,3,7, 14, 21 days
Vaccine should never be administered in Gluteal region.
Rabies awareness and vaccination program
36. Avian influenza (Bird flu)
Viral disease characterized by extremely high mortality.
The virus affect the respiratory, digestive, and nervous
system.
AI is an envelop, single stranded RNA virus. Two type of
projection called glycoprotein.
Haemaagglutinin (HA) , Neuraminidase (NA)
37. The haemagglutinin is responsible for attachment of the
virus to receptor present on the cell surface thus enables
the virus to enter into the cell
Neuraminidase which is an enzyme is responsible for
release of the new virus from the cell by its action on the
neuraminic acid in the receptors
38. Spread:
Direct contact between infected and susceptible birds,
Indirect contact through fine droplets suspended in air,
fomites
39. Symptoms:
Swelling of the head, face and upper neck of chicken
Excessive discharge from the eye
Haemorrhage under the skin in the feet
Cyanosis (bluish to purple discoloration) on the comb and
wattles
40.
41.
42. Bacterial disease:
Leptospirosis: caused by the organism a spirochete of
genus leptospira.
The disease in animals is characterized by fever, jaundice,
haemoglobinuria, abortion, still birth etc..
The mouse, rat, jacket, dog, pig, cat and cattle are
important reservoir
Among these, rat and small rodents particularly R.
noruegicus and mus musculus are most important
reservoir.
43. Who is at risk?
The farm workers
sewer worker
fisher man are high risk of infection.
44. Spread:
Through contact with an environment contamination by
urine
Aborted fetus and urine discharge of reservoir host,
Spoilage food
45. Leptospira can be enter through abraded skin and
mucus membrane during bathing or swimming in
lakes, pond, river, canal polluted with urine of
infected animals.
46. Man is considered as ‘dead end host’ but transplacental
transmission has been reported
Vertical transmission also occur in rodents
The disease manifest in human in 2 phases:
1st phase= septicaemic
2nd phase= due to immune response, fever, anorexia,
stiffness, jaundice, neurological signs, abortion and death
may occur
48. Glanders (Farcy): Is highly contagious, acute and chronic ,
fatal zoonotic disease of horse, mule and donkey.
Characterized by serial development of ulcerating nodules
on respiratory tract and skin (Farcy)
49. Burkholderia mallei, a gram negative bacteria, rod
shaped, aerobic non motile.
The disease is communicable to man
ETIOLOGY:
50. Ingestion of contaminated food and water
Direct contact with infected animal:
Abraded skin,
Mucous membrane
Person to person (Rare)
Aerogenous ( Rare)
Transmission:
51. Incubation period: 2 weeks may be less or more
Chronic form in horse and acute form in donkey and mule
Clinical sign:
52. Clinical signs and symptoms
In pulmonary form chronic cough and
symptoms of pneumonia my be seen.
If the nasal mucosa is affected a purulent and
oily nasal discharge may be present.
53. Acute form: high fever, coughing, Nasal discharge
(yellowish green exudate), ulcer on nasal mucosa and
nodules on skin.
In chronic form: animal are usually ill for several month
then death
54. Brucella: the disease is characteristics by Abortion (usually in
5-8 month of gestation), retained placenta, orchitis, epididymtis,
economic loss due to loss of progeny, milk yield and animal
protein.
Genus: Brucella
B. abortus is most widely spread where B. melitensis and B.
suis are irregularly disturbance.
B. melitensis is the prevalent species seen in man and cause a
more severe form of disease
55. Spread:
Ingestion ,close contact, inhalation or accidental
inoculation.
Beside these contact with aborted fetus and uterine
discharge
Animals product such as milk, meat products also play an
important role in disease transmission
Dairy products prepare from unpasteurized milk such as
soft cheese, yoghurts, ice-cream may contain high
concentration of bacteria and consumption of there is an
important cause of brucella
56.
57.
58.
59. In human: headache, muscular pain, insomnia,
anorexia, weakness, undulating fever (in evening)
death may be due to severe toxemia and endocarditis
60. Anthrax: This is rapidly fatal infectious disease often
characteristics by sudden death, exudation of tarry un
coagulated blood from the mouth, nares and anus,
splenomegaly, gelatinous infiltration of subcutaneous, and
sub serous tissue, malignant pustules or Escher formation on
skin.
Causative agent: brucella anthracis, gram
positive,endospore forming, rod shape
61. Anthrax spore are transmitted by contact with
infected carcass, hides, hair or bone meal.
62. If suspected of anthrax (on the basis of sudden death,
pathogenic symptoms and history), the carcass should
never be opened to avoid contamination of surrounding.
Generally quick and fairly reliable diagnosis blood smear
prepared rom ear clipping or laryngeal edema are stained
form M Fadyean reaction.
63.
64. Toxoplasmosis: caused by Toxoplasma gondii (protozoa)
and affect cattle, buffalo, sheep, goat and man
The principal host is Cat in which the organism reproduce
sexually and the cyst are shed in feces of cat and spread
the disease to other animal and man.
67. Congenital as well as acquired infection occur in man.
There may be abortion, premature birth, hydrocephaly,
microcephaly, splenomegaly, icterus, cerebral
calcification, mental retardation in congenital infection.
The disease is more important in immunocompermized
person
In toxoplasma number of abortion were reported in human
as well as animals.
68.
69. Prevention and control of zoonotic disease:
Veterinary play an important role in prevention and
control of zoonosis by virtue of their ability to destroy or
treat the disease and also controlling the movement of
domestic animals.
Quarantine
Environment hygiene
Chemoprophylaxis including deworming
Early diagnosis and proper treatment
Education of people about disease prevention/ awareness
campaign
70. Isolation of disease animal from healthy stock
Separation/ culling/ slaughtering of disease animal or
animals at risk.
Vector control
Reservoir control
Genetic improvement
Epidemiological diagnosis
Health education