- Leishmaniasis is a protozoal disease caused by Leishmania parasites and transmitted by sandfly bites. It is endemic in 88 countries across 5 continents.
- There are several clinical forms including cutaneous, mucocutaneous, and visceral leishmaniasis. Visceral leishmaniasis, also known as kala-azar, is the most serious form and if left untreated is usually fatal.
- India has the largest burden of visceral leishmaniasis worldwide, accounting for over half of global cases. It is endemic in 4 states, primarily Bihar where most cases occur.
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
Leishmaniasis is caused by a protozoa parasite from over 20 Leishmania species. Over 90 sandfly species are known to transmit Leishmania parasites. There are 3 main forms of the disease:
Visceral leishmaniasis (VL), also known as kala-azar is fatal if left untreated in over 95% of cases. It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anaemia. Most cases occur in Brazil, East Africa and in South-East Asia. An estimated 50 000 to 90 000 new cases of VL occur worldwide each year out of which only an estimated 25–45% are reported to WHO. In 2017, more than 95% of new cases reported to WHO occurred in 10 countries: Bangladesh, Brazil, China, Ethiopia, India, Kenya, Nepal, Somalia, South Sudan and Sudan.
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and causes skin lesions, mainly ulcers, on exposed parts of the body, leaving life-long scars and serious disability or stigma. About 95% of CL cases occur in the Americas, the Mediterranean basin, the Middle East and Central Asia. In 2017 over 95% of new CL cases occurred in 6 countries: Afghanistan, Algeria, Brazil, Colombia, Iran (Islamic Republic of), Iraq and the Syrian Arab Republic. It is estimated that between 600 000 to 1 million new cases occur worldwide annually.
Mucocutaneous leishmaniasis leads to partial or total destruction of mucous membranes of the nose, mouth and throat. Over 90% of mucocutaneous leishmaniasis cases occur in Bolivia (the Plurinational State of), Brazil, Ethiopia and Peru.
Transmission
Leishmania parasites are transmitted through the bites of infected female phlebotomine sandflies, which feed on blood to produce eggs. The epidemiology of leishmaniasis depends on the characteristics of the parasite and sandfly species, the local ecological characteristics of the transmission sites, current and past exposure of the human population to the parasite, and human behaviour. Some 70 animal species, including humans, have been found as natural reservoir hosts of Leishmania parasites.
(WHO, 2019)
https://www.who.int/news-room/fact-sheets/detail/leishmaniasis
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
A basic description of Leishmania spp. along with Old and New world Leishmaniasis regarding Parasite morphology, Life Cycle, Pathogenesis, Clinical manifestations, Laboratory Diagnosis and Treatment.
Leishmaniasis is caused by a protozoa parasite from over 20 Leishmania species. Over 90 sandfly species are known to transmit Leishmania parasites. There are 3 main forms of the disease:
Visceral leishmaniasis (VL), also known as kala-azar is fatal if left untreated in over 95% of cases. It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anaemia. Most cases occur in Brazil, East Africa and in South-East Asia. An estimated 50 000 to 90 000 new cases of VL occur worldwide each year out of which only an estimated 25–45% are reported to WHO. In 2017, more than 95% of new cases reported to WHO occurred in 10 countries: Bangladesh, Brazil, China, Ethiopia, India, Kenya, Nepal, Somalia, South Sudan and Sudan.
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and causes skin lesions, mainly ulcers, on exposed parts of the body, leaving life-long scars and serious disability or stigma. About 95% of CL cases occur in the Americas, the Mediterranean basin, the Middle East and Central Asia. In 2017 over 95% of new CL cases occurred in 6 countries: Afghanistan, Algeria, Brazil, Colombia, Iran (Islamic Republic of), Iraq and the Syrian Arab Republic. It is estimated that between 600 000 to 1 million new cases occur worldwide annually.
Mucocutaneous leishmaniasis leads to partial or total destruction of mucous membranes of the nose, mouth and throat. Over 90% of mucocutaneous leishmaniasis cases occur in Bolivia (the Plurinational State of), Brazil, Ethiopia and Peru.
Transmission
Leishmania parasites are transmitted through the bites of infected female phlebotomine sandflies, which feed on blood to produce eggs. The epidemiology of leishmaniasis depends on the characteristics of the parasite and sandfly species, the local ecological characteristics of the transmission sites, current and past exposure of the human population to the parasite, and human behaviour. Some 70 animal species, including humans, have been found as natural reservoir hosts of Leishmania parasites.
(WHO, 2019)
https://www.who.int/news-room/fact-sheets/detail/leishmaniasis
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
By the end of this presentation we’ll be able to learn about- -Geographical distribution of leishmania parasites- Know the different stages of leishmania parasites and their morphology.-Describe the lifecycle of leishmania.-Causes and pathogenesis of leishmania -Preventive measures of leishmaniasis
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
Visceral leishmaniasis is spread by sandfly bites. This type of leishmaniasis affects the internal organs, usually the spleen, liver and bone marrow.
Some people have no symptoms. For others, symptoms may include fever, weight loss and swelling of the spleen or liver.
By the end of this presentation we’ll be able to learn about- -Geographical distribution of leishmania parasites- Know the different stages of leishmania parasites and their morphology.-Describe the lifecycle of leishmania.-Causes and pathogenesis of leishmania -Preventive measures of leishmaniasis
LUMEN DWELLING FLAGELLATES - GIARDIA
REFS:
INTERNATIONALLY ACCEPTED BOOK OF MEDICAL PARASITOLOGY BY K. D. CHATTERJEE
TEXT BOOK OF MEDICAL PARASITOLOGY BY PANIKER
IMAGE SOURCES : FROM INTERNET
Visceral leishmaniasis is spread by sandfly bites. This type of leishmaniasis affects the internal organs, usually the spleen, liver and bone marrow.
Some people have no symptoms. For others, symptoms may include fever, weight loss and swelling of the spleen or liver.
: Parasitic water pollution in the Nile River (Schistosoma & Giardia lamblia)MenrvaSorial
Causative organism.
Geographical distribution.
Epidemiology & Risk factors.
Mode of Transmission.
Vector (if available).
Habitat.
Life cycle (including infective stage, Diagnostic stage, Final host, Intermediate host and Reservoir).
-According to your lab group assignment topic, you must mention at least two examples (Causative organisms) for the required type of parasitic infection and their prevalence in Egypt. -Then discuss briefly the mentioned examples covering all the following points:
As a pharmacist, how could you identify and confirm a patient with such disease?
(NB: Identification and confirmation include the signs and symptoms and the diagnostic tests in details)
What are the therapeutic options available (suggest a line of treatment).
How can we prevent & control such disease?
Malaria(Plasmodium falciparum)- Epidemiology, Life Cycle, Prevention and Erad...Sarath
Malaria(Plasmodium falciparum)- Epidemiology, Life Cycle, Prevention and Eradication.
Contains Videos in two slides. So try using Power Point 2010.
My email : doc.sarathrs@gmail.com
Mucormycosis ppt by Dr. Bomkar bam ENT M.S.Bomkar Bam
mucormycosis in the covid era in India. it is mostly seen in the post-recovery patient of covid - 19. most of the data are derived from the 2nd wave of covid in India.
Rabies presentation for medical undergraduate students Khan Amir Maroof
for MBBS phase II students
29th July 2021
with videos and pictures
For educational use only and NOT FOR PROFIT
www.consortiumagainstrabies.com
Credit: Dr Anurag Agarwal (Gen Secretary, Consortium Against Rabies)
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Cambridge International AS A Level Biology Coursebook - EBook (MaryFosbery J...
Leishmaniasis
1.
2. Varied collection of protozoal diseases
Named after Leishman - First identified the organisms
in 1901
Smears taken from a man who had died of “Dum
Dum” fever
Annually - Two million cases worldwide
Has emerged as an AIDS - associated opportunistic
infection
4. Endemic in 88 countries on five continents
Cutaneous Leishmaniasis cases occur in Iran,
Afghanistan, Syria, Saudi Arabia, Brazil and Peru
Visceral Leishmaniasis cases occur in
Bangladesh, Brazil, India and Sudan
World Health Organization estimates that 350
million people are at risk
5. 2.4 million disability - adjusted life years
Around 7,00,000 deaths per year
WHO South East Asia Region - 200 million
people in the Region are “at risk”
6. World’s largest foci of Visceral Leishmaniasis, accounting for
50% of the total burden
Endemic in 4 states in India:
Bihar- 32 districts Jharkhand- 4 districts
West Bengal- 11 districts Uttar Pradesh- 5 districts
An estimated 165.4 million population is at risk
About 1,00,000 cases occur annually
8. 19 protozoan species
Genus Leishmania
Amastigote- obligate intracellular parasites and
divide in macrophages- diagnostic phase
Promastigotes- extracellular present in the
arthropod vectors- infective phase
Absence of cross immunity
9. Leishmania donovani complex
Leishmania donovani, L. infantum and L. chagasi
Leishmania mexicana complex
L. mexicana, L. amazonensis and L. venezuelensis
Leishmania tropica
Leishmania major
Leishmania aethiopica
In India: Leishmania donovani
10.
11. Female sand flies of the genus Lutzomyia in
the Americas and Phlebotomus in other parts
of the world
Sandflies breed in cracks and crevices in the
soil and buildings, tree holes and caves
Sandflies are active in the evening and night -
time hours
In India, Phlebotomus argentipes is a proven
vector of KalaAzar.
12. Cutaneous form mainly zoonotic,
- humans are accidentally exposed
Indian Kala - Azar is anthroponotic with humans
being the only known reservoir of infection
Peak age of infection is 5 to 9 years
Males
Poor socio-economic background
Common in various farming practices, forestry,
mining and fishing
13. Mostly confined to the plains
Overcrowding,
Poor ventilation
High relative humidity, warm temperature
Accumulation of organic matter in the
environment facilitates transmission
14. Transmitted by the bite of infected female
sandflies
Rarely: initiated by amastigotes via blood
(shared needles, transfusion, transplacental
spread) or organ transplantation
16. Typical lesion :
Develops at the site where promastigotes are
injected by the vector
A papule - papule enlarges – ulcerates
Multiple lesions may be present
17.
18. Infected with Leishmania braziliensis
Begins with nasal stuffiness and inflammation
Ulceration of the nasal mucosa and septum
follows.
The lips, cheeks, soft palate, pharynx and
larynx may eventually be involved, resulting in
substantial disfigurement
More common among immunosuppressed
with neoplasms or AIDS
19. Recurrent fever
Loss of appetite, pallor and weight loss with
progressive emaciation
Weakness
Splenomegaly - spleen enlarges rapidly to massive
enlargement, usually soft and non-tender
Liver - enlargement not to the extent of spleen, soft,
smooth surface, sharp edge
20.
21. Death often occurs due to a secondary bacterial
infection, such as
Pneumonia, Septicemia,
Dysentery, Tuberculosis,
Measles Other viral infections
22. Anaemia, Neutropenia, Thrombocytopenia and
pronounced hypergammaglobulinemia.
The anaemia is usually normocytic, normochromic,
unless there is concomitant iron deficiency
Leukopenia can be profound with white blood cell
counts below 1000/mL
The globulin level can reach 9 or 10 g/dl.
23. Some patients in India and Africa develop skin lesions
following treatment, ranging from hyperpigmented macules
to frank nodules
Skin lesions typically appear 1 or 2 years after treatment and
may persist for as long as 20 years.
Persistence of lesions beyond one year is associated with high
anti - leishmanial antibody titers and negative leishmanial skin
test responses
Anti - leishmanial treatment is indicated in Indian PKDL
24. Immunocompromised individuals progress to develop the
disease far more often than immunocompetent people
It quickly accelerates the onset of AIDS and shortens the
life expectancy of HIV - infected people.
Visceral Leishmaniasis is considered a major contributor
to a fatal outcome HIV in co - infected patients
25. Parasite Identification:
Wright-Giemsa stain is used for identifying amastigotes
in tissue sections
Serology:
Anti-leishmanial antibody titers are typically present in:
▪ High titer in people with Visceral Leishmaniasis and
▪ Low titer or undetectable in those with Cutaneous
Leishmaniasis.
Assays such as ELISA, IFAT and agglutination assays,
rk-39 rapid diagnostic test
26. Skin Test
Intradermal leishmanin (Montenegro) skin test
Positive Negative
- Asymptomatic
- Self resolving
leishmania
- Following successful
treatment
- Progressive visceral
Leishmaniasis
- Diffuse cutaneous
Leishmaniasis
27. Aldehyde test
Napier is a simple test
1 to 2 ml of serum from a case of kala-azar is taken
and a drop or two of 40 per cent formalin is added.
A positive test is indicated by jellification to milk-
white opacity like the white of a hard-boiled egg
so that in ordinary light newsprint is invisible
through it
28. FIRST LINE OF DRUGS
SHORT TERM LONG TERM
SSG
SENSITIVITY
>90%
SSG
SENSITIVITY
<90%
SSG 20
mg/Kg i.m or
i.v for 20
days
Amphotericin B
1mg/kg i.v daily
or alternate days
SSG
RESISTANCE
>20%
SSG
SENSITIVITY
>80%
MILTEFOSINE
100mg/day
divided doses for
4 weeks
SSG
20mg/kg/ day
i.m/i.v for 30
days
CONTROL OF RESERVOIR
29. SECOND LINE OF DRUGS
SSG FAILURE SSG AND MILTEFOSINE FAILURE
Amphotericin B
1mg/kg i.v daily
or alternate
LIPOSOMAL
AMPHOTERICIN
B
30. Treatment of PKDL :
SSG in usual dosage for kala azar
Could be given for 120 days.
Repeated 3-4 courses of Amphotericin B can be
given in patients failing SSG treatment.
31. Sandfly Control: using residual insecticides, DDT used as
the first choice
BHC may be used as second line of defence
Santation measures like removal of breeding places
Personal prophylaxis: The short - term visitor to an
endemic area should use personal protective measures to
avoid sand fly bites
The application of DEET (diethyltoluamide)
Use of fine mesh nets
Application of insect repellants
32. 1. The disease is endemic in following three
countries of the WHO South East Asia Region
except:
(a). Bangladesh (b) India (c) Nepal (d) Sri lanka
2. The disease is reported in _________ no of
districts in India:
(a) 51 (b) 52 (c) 53 (d) 54
33. 3. State which accounts for more than 90 per cent of the
cases in India
(a) Uttar Pradesh (b) Bihar (c) Assam (d) M.P
4. Leishmania donovani complex comprises of all except
(a) Leishmania infantum (b) Leishmania chagasi
(c) Leishmania venezuelensis (d) Leishmania donovani
5. Cutaneous Leishmaniasis is also known as all the following
except
(a) Oriental sore (b) Aleppo evil (c) Delhi boil (d) Espundia
Answers : (1) d; (2) b; (3) b; (4) c; (5) a.
Editor's Notes
spontaneously healing skin ulcer to overwhelming visceral disease
Similarly AIDS increases the risk of Visceral Leishmaniasis by 100 - 1000 times in endemic areas
containing insect repellents to exposed skin and under pant and shirt cuffs, the use of fine – mesh screens or insect nets, and the application of insecticide (usually permethrin or other pyrethroids) to clothing and bed nets - decrease the risk of transmission