The document provides an overview of the endocrine system and its major components. It discusses the following key points in 3 sentences:
The endocrine system uses hormones to regulate metabolic processes. It includes glands like the pituitary, thyroid, parathyroids, adrenals, pancreas and gonads that secrete hormones into the bloodstream. These target distant cells and trigger metabolic responses, with the hypothalamus and pituitary acting as the primary controllers of the other endocrine glands.
The endocrine system is a messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In vertebrates, the hypothalamus is the neural control center for all endocrine systems.
The endocrine system is a messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In vertebrates, the hypothalamus is the neural control center for all endocrine systems.
The endocrine system refers to the collection of glands of an organism that secrete hormones directly into the circulatory system to be carried towards distant target organs.
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Endocrine glands are glands of the endocrine system that secrete their products, hormones, directly into the blood rather than through a duct. The major glands of the endocrine system include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus and adrenal glands.
Classification of hormones, mechanism of hormone action, structure
and functions of pituitary gland, thyroid gland, parathyroid gland, adrenal gland, pancreas, pineal gland, thymus and their disorders.
The endocrine system refers to the collection of glands of an organism that secrete hormones directly into the circulatory system to be carried towards distant target organs.
www.novaivifertility.com
Endocrine glands are glands of the endocrine system that secrete their products, hormones, directly into the blood rather than through a duct. The major glands of the endocrine system include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus and adrenal glands.
Classification of hormones, mechanism of hormone action, structure
and functions of pituitary gland, thyroid gland, parathyroid gland, adrenal gland, pancreas, pineal gland, thymus and their disorders.
22.chemical control & coordination in one shot.pptxanonymous
There are special chemicals which act as hormones and provide chemical
coordination, integration and regulation in the human body. These hormones
regulate metabolism, growth and development of our organs, the endocrine glands
or certain cells. The endocrine system is composed of hypothalamus, pituitary
and pineal, thyroid, adrenal, pancreas, parathyroid, thymus and gonads (testis
and ovary). In addition to these, some other organs, e.g., gastrointestinal tract,
kidney, heart etc., also produce hormones. Progesterone plays a major role in the maintenance of pregnancy as
well as in mammary gland development and lactation. The atrial wall of the heart
produces atrial natriuretic factor which decreases the blood pressure. Kidney
produces erythropoietin which stimulates erythropoiesis. The gastrointestinal tract
secretes gastrin, secretin, cholecystokinin and gastric inhibitory peptide. These
hormones regulate the secretion of digestive juices and help in digestion.
Antepartum haemorrhage (APH) is defined as bleeding from or in to the genital tract, occurring from 24+0 weeks of pregnancy and prior to the birth of the baby. The most important causes of APH are placenta praevia and placental abruption, although these are not the most common.
Types 1 and 2 are classified as minor placental praevia as these typically result in minor antepartum haemorrhaging. Types 3 and 4 are referred to as major placental praevia due to the risk of heavy haemorrhaging in the case of a rupture due to the location of placental attachment.
Disorders of the placenta including: FGR, pre-eclampsia, placental abruption and abnormal (velamentous) cord insertion are associated with over 50% of stillbirths and are frequently cited as the primary cause of death [1–3]. Abnormal placental structure and function significantly increases the risk of stillbirth.
Placenta accreta, placenta increta, and placenta percreta. Abnormal placental implantation (accreta, incretak, and percreta) is described using a general clinical term, respectively, morbidly adherent placenta (MAP) [2] or “abnormal invasive placenta” (AIP).
A miscarriage, or spontaneous abortion, is an event that results in the loss of a fetus before 20 weeks of pregnancy. It typically happens during the first trimester, or first three months, of the pregnancy. Miscarriages can happen for a variety of medical reasons, many of which aren't within a person's control.
Chromotherapy Chromotherapy, sometimes called color therapy, colorology or cr...jagan _jaggi
Chromotherapy
Chromotherapy, sometimes called color therapy, colorology, or chromotherapy, is an alternative medicine method, which is considered pseudoscience.
Color therapy (or chromotherapy) is an alternative remedy that uses color and light to treat physical or mental health by balancing the body's energy centers, also known as chakras. This concept dates back to ancient Egyptians who used sun-activated solarium rooms constructed with colored glass for therapeutic purposes.
Behavior therapy or behavioral psychotherapy is a broad term referring to cl...jagan _jaggi
Behavioral therapy is an umbrella term for types of therapy that treat mental health disorders. This form of therapy seeks to identify and help change potentially self-destructive or unhealthy behaviors. It functions on the idea that all behaviors are learned and those unhealthy behaviors can be changed.
Behavior therapy
Behavior therapy or behavioral psychotherapy is a broad term referring to clinical psychotherapy that uses techniques derived from behaviorism and/or cognitive psychology.
light therapy is meant to compensate for the lack of exposure to sunlight th...jagan _jaggi
Light therapy
Description
DescriptionLight therapy—or phototherapy, classically referred to as heliotherapy—consists either of A. exposure to daylight or some equivalent form of light as a treatment for seasonal affective disorder or B. exposure of the skin to specific wavelengths of light using polychromatic polarized light to treat a skin condition.
Center for Mental Health Services, also known as community mental health teams in the United Kingdom, support or treat people with mental disorders in a domiciliary setting, instead of a psychiatric hospital.
The Government of India has launched the National Mental Health Programme (NMHP) in 1982, keeping in view the heavy burden of mental illness in the community, and the absolute inadequacy of mental health care infrastructure in the country to deal with it
Inotropic agents, or inotropes, are medicines that change the force of your h...jagan _jaggi
An inotrope is an agent that alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction.
A neurological examination is the assessment of sensory neuron and motor responses, especially reflexes, to determine whether the nervous system is impaired. This typically includes a physical examination and a review of the patient's medical history, but not deeper investigation such as neuroimaging.
Transposition of the great arteries is a serious but rare heart defect present at birth (congenital), in which the two main arteries leaving the heart are reversed (transposed). The condition is also called dextro-transposition of the great arteries.
If you've had a heart attack, you may have already had certain procedures to help you survive your heart attack and diagnose your condition. For example, many heart attack patients have undergone thrombolysis, a procedure that involves injecting a clot-dissolving agent to restore blood flow in a coronary artery.
Defibrillation -cardioversion Cardioversion is a medical procedure by which a...jagan _jaggi
Defibrillation is a technique used in emergency medicine to terminate ventricular fibrillation or pulseless ventricular tachycardia. It uses an electrical shock to reset the electrical state of the heart so that it may beat to a rhythm controlled by its own natural pacemaker cells.
Cardioversion is a medical procedure by which an abnormally fast heart rate (tachycardia) or other cardiac arrhythmia is converted to a normal rhythm using electricity or drugs.
Cathlab procedures, it's contains what are the procedure doing in the cathla...jagan _jaggi
Cath lab is an examination room in a hospital or clinic with diagnostic imaging equipment used to visualize the arteries of the heart and the chambers of the heart and treat any stenosis or abnormality found.
Arterial blood gas test Diagnostic testjagan _jaggi
Arterial blood gas test
Diagnostic test
Description , An arterial-blood gas test measures the amounts of arterial gases, such as oxygen and carbon dioxide. An ABG test requires that a small volume of blood be drawn from the radial artery with a syringe and a thin needle, but sometimes the femoral artery in the groin or another site is used.
Obstetric instruments power point presentaion jagan _jaggi
Image result for obstetric instrumentswww.slideshare.net
Our gynaecology instruments include: Forceps & Clamps - For uterine and caesarian birthing, hysterectomy and other obstetrics and gynae surgery. Cervical Dilators - For stretching the cervical wall and dilating the cervical muscles. Vaginal Speculums - Used in procedures such as the pap smear.
Florence nightingale was an English social reformer and statistician, and the...jagan _jaggi
Florence Nightingale, OM, RRC, DStJ (/ˈnaɪtɪnɡeɪl/; 12 May 1820 – 13 August 1910) was an English social reformer and statistician, and the founder of modern nursing. Nightingale came to prominence while serving as a manager and trainer of nurses during the Crimean War, in which she organized to care for wounded soldiers.
To strengthen your pelvic floor muscles, sit comfortably and squeeze the muscles 10-15 times in a row. Don't hold your breath or tighten your stomach, buttock or thigh muscles at the same time. When you get used to doing pelvic floor exercises, you can try holding each squeeze for a few seconds.
Breastfeeding techniques The World Health Organization and UNICEF have recomm...jagan _jaggi
Breastfeeding, also known as nursing, is the feeding of babies and young children with milk from a woman's breast. Health professionals recommend that breastfeeding begin within the first hour of a baby's life and continue as often and as much as the baby wants
The World Health Organization and UNICEF have recommended for a decade that mothers breastfeed for at least two years. But most US women who nurse stop before their baby is six months old – and many never start at all.
Alcoholism, also known as alcohol use disorder (AUD), is a broad term for any drinking of alcohol that results in mental or physical health problems. The disorder was previously divided into two types: alcohol abuse and alcohol dependence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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2. Endocrine System
• Endocrine system regulates long term ongoing
metabolic activity
• The endocrine system uses chemicals messenger called
hormones to “communicate”.
• Hormones alter metabolic activities of tissues
• A hormone is secreted by a group of specialized cells
called gland
• Hormones are transported by the blood vessels
• Paracrine communication involves chemical
messengers between cells within one tissue
3. 3
Overview of the Endocrine System
• System of ductless glands that secrete hormones
• Hormones are “messenger molecules”
• Circulate in the blood
• Act on distant target cells
• Target cells respond to the hormones for
which they have receptors
• The effects are dependent on the programmed
response of the target cells
• Hormones are just molecular triggers
6. • Based on their chemical structure hormones are
classified into three general classes (groups) of
hormones.
• 1) Amino acid derivatives hormones e.g. epinephrine
• Structurally similar to amino acids
• 2) Peptide hormones e.g. insulin
• Chains of amino acids
• 3) Lipid derivatives hormones e.g. steroid hormones
(prostaglandin is an example of a steroid hormone)
Hormone structure
7. Hormones Transportation
• Hormones can be
• Freely circulating
• Rapidly removed from bloodstream
• Bound to transport proteins e.g. albumin or
globulin
8. • Each hormone’s shape is specific and can be
recognized by the corresponding target cells
• The binding sites on the target cells are called
hormone receptors.
• Receptors for peptide hormones, are located
on the surface of cell membranes because they
can not cross the membrane to enter the cell
• Thyroid and steroid hormones can cross the
membrane and bind to receptors in the
cytoplasm or nucleus
Mechanisms of hormone action
9. • Hypothalamus regulates the activity of the
nervous and endocrine systems
• Hypothalamus secrets regulatory hormones
(releasing hormones and inhibiting hormones)
that control the activity of the pituitary gland
• Releasing/inhibiting hormones secreted by the
hypothalamus either stimulate or inhibit
activity of pituitary gland
Control of endocrine activity
11. • The pituitary gland is called the “master gland”
but it is under the control of the hypothalamus.
• Hypothalamus and pituitary gland control many
other endocrine functions.
• Pituitary Gland releases nine important peptide
hormones
• All nine bind to membrane receptors
• Pituitary gland is divided into posterior and
anterior lobe
The Pituitary Gland
13. • Anterior lobe of pituitary gland produces 7
hormones
• 1) Thyroid stimulating hormone (TSH)
• TSH triggers the release of thyroid hormones by the thyroid
glands
• Thyrotropin releasing hormone promotes the release of TSH
• 2) Adrenocorticotropic hormone (ACTH)
• ACTH stimulates the release of glucocorticoids by the adrenal
gland
• Corticotrophin releasing hormone causes the secretion of ACTH
• 3) Follicle stimulating hormone (FSH)
• FSH stimulates follicle development and estrogen secretion in
females and sperm production in males
Hormones of the adenohypophysis
The anterior lobe (adenohypophysis)
14. • 4) Leutinizing hormone (LH)
• LH causes ovulation and progestin (progesterone) production in
females and androgen (testosterone) production in males
• Gonadotropin releasing hormone (GNRH) promotes the secretion
of FSH and LH
• 5) Prolactin (PH)
• PH stimulates the development of mammary glands and milk
production
• 6) Growth hormone (GH or somatotropin)
• GH stimulates cell growth and replication
• Growth-hormone releasing hormone
(GH-RH)
• Growth-hormone inhibiting hormone
(GH-IH)
• 7) Melanocyte stimulating hormone (MSH)
• Stimulates melanocytes to produce melanin
The anterior lobe (adenohypophysis)
15. • The posterior lobe of the pituitary gland secretes two
hormones: Antiduretic Hormone and Oxytocin.
• 1) Antidiuretic hormone (ADH)
• Decreases the amount of water lost at the
kidneys
• Elevates blood pressure
• 2) Oxytocin
• Stimulates contractile cells in mammary glands
• Stimulates smooth muscle cells in uterus
The posterior lobe of the pituitary gland
(neurohypophysis)
16. 16
Hypothalamus
• Releasing hormones (releasing factors) of hypothalamus
Secreted like neurotransmitters from neuronal axons into capillaries and
veins to anterior pituitary (adenohypophysis)
TRH (thyroid releasing hormone) -----turns on* TSH
CRH (corticotropin releasing hormone) -----turns on ACTH
GnRH (gonadotropin releasing hormone) ---turns on FSH and LH
PRF (prolactin releasing hormone) -----turns on PRL
GHRH (growth hormone releasing hormone) ----turns on GH
*
17. • Inhibiting hormones of hypothalmus
PIF (prolactin inhibiting factor) -----turns off PRL
GH (growth hormone) inhibiting hormone ---turns off GH
The hypothalamus controls secretion of hormones which in
their turn control the secretion of hormones by the thyroid
gland, the adrenal cortex and gonads: in this way the
brain controls these endocrine glands
18. • Thyroid gland is located near the thyroid cartilage
of the larynx
• The two lobes of thyroid gland is connected by an
isthmus
• Microscopically it has 2 distinct population of cells:
Flicular Cell (produce thyroid hormone) and C cell
(produce calcitonin)
The thyroid
19. 19
• Thyroid is composed of spherical follicles
• Follicle cells: produce thyroglobulin, the
precursor of thryoid hormone (thyroxin)
• Colloid lumen is of thyroglobulin
• Parafollicular “C” cells: produce calcitonin
21. • Thyroid gland release several hormones such
as thyroxine (T4) and triiodothyronine (T3)
• Thyroid hormones (T4 and T3) are
transported by to thyroid binding globulins
(TBG), and albumin
22. Functions of Thyroid hormones include:
• Increases the basal metabolic rate
• The rate at which the body uses oxygen to transform
nutrients (carbohydrates, fats and proteins) into energy
• Increasing ATP production, when bound to
mitochondria.
• Activating genes that control energy utilization,
when bound to receptors
• Exert a calorigenic effect
23. 23
Some Effects of Thyroid Hormone
(Thyroxine)
• Affects many target cells throughout the body; some
effects are
• Protein synthesis
• Bone growth
• Neuronal maturation
• Cell differentiation
24. • C cells of thyroid gland produce calcitonin
• Calcitonin helps to regulate calcium
concentration in body fluids
26. 26
Parathyroids
(two types of cells)
• chief cells
• oxyphil cells (unknown
function)
• Chief cells produce PTH
• Parathyroid hormone, or
parathormone
• A small protein hormone
27. • Chief cells produce parathyroid hormone (PTH)
in response to lower than normal calcium
concentrations
• Parathyroid hormones plus calcitriol are primary
regulators of calcium levels in healthy adults
Parathyroid glands
28. The Homeostatic Regulation of Calcium Ion
Concentrations
• When calcium levels decrease in the blood, parathyroid glands produce
PTH
• PTH increase blood calcium level by:
1. Releasing stored calcium from the bones
2. Stimulating production of calcitriol at the kidney. Calcitriol
increases absorption of calcium by the digestive system
3. Enhance reabsorption of calcium by the kidneys
• When calcium levels increase in the blood, thyroid glands produce
calcitonin.
• Calcitonin decreases blood calcium level by:
1. Increasing excretion of calcium by the kidneys
2. Increase calcium deposition in the bones
3. Stop osteoclast
32. • Manufactures steroid hormones derived from
cholesterol (corticosteroids).
• Secretes lipid-based steroid hormones, called
“corticosteroids” – “cortico” as in “cortex
The Adrenal Glands
Adrenal cortex
33. • Corticosterioid hormones are divided into 3 functional
groups
• Mineralocorticoids (Aldosterone)
• Regulate mineral and salt balance by renin-
angiotensis-aldosterone system
• Aldosterone is the main one
• Glucocorticoids (cortisol and cortisone)
• Regulate glucose levels i.e. they increase
gluconeogenesis and decrease protein synthesis
• Cortisol (hydrocortisone) is the main one
• Decrease inflammation response
• Androgens also called sex hormones
34. The Adrenal Glands
Adrenal medulla
• Responsible for flight-or-fight response
• Produces epinephrine and norepinephrine
35. 35
The Pineal Gland
• At the end of a short stalk on the roof of the
diencephalon
• Contains pinealocytes
• Synthesize melatonin
• Pinealocytes with dense calcium particles
• Can be seen on x-ray (because of Ca++)
37. 37
The Pancreas
Exocrine and endocrine cells
• Acinar cells (forming most of the pancreas)
• Exocrine function
• Secrete digestive enzymes
• Islet cells (of Langerhans)
• Endocrine function
38. • Clusters of endocrine cells within the pancreas
called Islets of Langerhans or pancreatic islets
• Alpha cells secrete glucagons
• Glucagon raises blood glucose by increasing the rates
of glycogen breakdown and glucose manufacture by
the liver
• Beta cells secrete insulin
• Insulin lowers blood glucose by increasing the rate of
glucose uptake and utilization
• Delta cells secrete GH-IH secrete somatostatin
• inhibits glucagon
• F cells secrete pancreatic polypeptide
The pancreatic islets
40. Diabetes
• Type I – Insulin dependent diabetes
• Caused by autoimmune destruction of beta
cells
• Type II – non insulin dependent diabetes
• Caused by body resisting the effects of insulin
at its receptor.
• Symptoms: Polyuria (inreased frequency of
urination), polydipsia (increased thirst)
42. • Produce calcitriol and erythropoietin (EPO) and the
enzyme rennin
• Calcitriol = stimulates calcium and phosphate ion
absorption along the digestive tract
• EPO stimulates red blood cell production by bone
marrow
• Renin converts angiotensinogen to angiotensin I
• Angiotensin I is converted to angiotensin II at the lungs
• Agiotensin II:
1. Stimulates production of aldosterone by the
adrenal glands
2. Stimulates release of ADH by the pituitary gland
3. Promotes thirst
4. Elevates blood pressure
The kidneys
44. 44
The Gonads (testes and ovaries)
main source of the steroid sex hormones
• Testes
• Interstitial cells secrete androgens
• Primary androgen is testosterone
• Maintains secondary sex characteristics
• Helps promote sperm formation
• Ovaries
• Androgens secreted by thecal folliculi
• Directly converted to estrogens by follicular granulosa cells
• Granulosa cells also produce progesterone
• Corpus luteum also secretes estrogen and progesterone
45. • The Heart
• Specialized muscle cells produce natriuretic peptides in
response to high blood pressure
• Natriuretic peptide generally has the opposite actions
of angiotensin II
• The Intestine
• Produce hormones important to the coordination of
digestive activities
• The Thymus
• Produces thymosins
• Help develop and maintain normal immune defenses
The heart, The intestines and the Thymus
46. • Normal growth requires the interaction of several
endocrine organs
• Six hormones are important
• GH
• Thyroid hormones
• Insulin
• PTH
• Calcitriol
• Reproductive hormones
Hormones and growth
47. • Leptin, a feedback control for appetite
• Resistin, which reduces insulin sensitivity
Adipose tissues secrete
48. • Many hormones affect the CNS
• Changes in the normal mixture of hormones
significantly alters intellectual capabilities,
memory, learning and emotional states
Hormones and behavior