The endocrine system is comprised of glands that secrete hormones directly into the bloodstream to regulate distant organs and systems. The major endocrine glands include the pituitary, thyroid, parathyroid, adrenal, pancreas, ovaries, testes, and pineal glands. These glands secrete hormones that govern critical body functions like reproduction, stress response, growth, energy levels, and homeostasis. The hormones travel through the circulatory system to target organs and allow for integration of body systems and physiological equilibrium.