'Rasasastra' ,is the science of metals , minerals , other toxic herbs , which are applied for attaining two goals. It is either used in the perspective of metallurgy, where lower metals are converted in to higher metals. It is otherwise used for the attainment of supreme health. This science , with both the applications were once well practiced in our country. But due to several factors, this divine science has been restricted to treatment aspect. 'Kshetreekarana' is the method of preparing the body to be eligible for administering processed divine mercury. In the midst various references Kshetreekarana generally , includes two steps. The first step is implementing Panchakarma therapy and second step involves administration of special formulations to attain a healthy condition to accept the divine mercury.