Daily administration of prednisolone during infections significantly reduced relapse rates in children with frequently relapsing nephrotic syndrome compared to alternate day dosing. The intervention group had 44 relapses compared to 76 in the control group, with daily dosing reducing relapse rates by 59%. Poisson regression analysis found daily dosing reduced the mean number of relapses per infection from 0.35 to 0.13. The number needed to treat was 6, indicating daily dosing during infections effectively reduced relapse frequency.
This is a case on Diastolic heart failure with Type 2 Diabetes mellitus. Here we have discussed the pharmaceutical care plan (SOAP) about the treatment and non pharmacological approaches to treat the specified conditions
Hello members...this powerpoint deals with A journal presentation, that aims at highlighting the "Efficacy & safety of Lacosamide in painful diabetic neuropathy patients".
This also elucidates a model of "Journal club presentation" for interested students.
Happy reading!!
:)
This is a case on Diastolic heart failure with Type 2 Diabetes mellitus. Here we have discussed the pharmaceutical care plan (SOAP) about the treatment and non pharmacological approaches to treat the specified conditions
Hello members...this powerpoint deals with A journal presentation, that aims at highlighting the "Efficacy & safety of Lacosamide in painful diabetic neuropathy patients".
This also elucidates a model of "Journal club presentation" for interested students.
Happy reading!!
:)
journal club is one of the important academic activity during MD/MS courses. Present PPT is a journal club presented on an article that compare two antihypertensives and the presentation also includes critical analysis of the article.
Presentation performed for highlighting VERIFY: Galvus-met trials superiority in managing newly diagnosed DMT2 patients with preserving B cell function, evidence.
journal club is one of the important academic activity during MD/MS courses. Present PPT is a journal club presented on an article that compare two antihypertensives and the presentation also includes critical analysis of the article.
Presentation performed for highlighting VERIFY: Galvus-met trials superiority in managing newly diagnosed DMT2 patients with preserving B cell function, evidence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
3. Complex disturbances in
immune system
Genetic Mutations /
Mutations in proteins
Extensive effacement of podocyte foot processes
Increased permeability of glomerular capillary
wall
Massive proteinuria
Hypoalbuminaemia
Edema
PATHOPHYSIOLOGY
4.
5.
6. DEFINITIONS
Remission Urine albumin nil or trace for 3 consecutive
early morning specimens
Relapse Urine albumin 3+ or 4+ for 3 consecutive early
morning specimens
Frequent relapses Two or more relapses in initial six months or
more than three relapses in any twelve
months.
7. Daily Corticosteroids Reduce Infection-
associated Relapses in Frequently
Relapsing Nephrotic Syndrome: A
Randomized Controlled Trial
Name of the journal : Clinical journal of the American
Society of Nephrology
Volume : 6
Page No: 63 – 69
Year of publication: 2011
Impact factor = 6.18
8. Ashima Gulati,
Aditi Sinha,
Aparna Math,
Pankaj Hari,
Arvind Bagga
Vishnubhatla Sreenivas
Division of Nephrology,
Departments of Pediatrics,
All India Institute of Medical Sciences,
New Delhi, India
Division of Nephrology,
Departments of Biostatistics,
All India Institute of Medical Sciences,
New Delhi, India
10. INTRODUCTION
Idiopathic nephrotic syndrome
40 to 50% show frequent relapses
Prolonged course with risks of life threatening infections,
thromboembolic complications
side effects of therapy
Need to examine safe and effective treatment regimens for
patients with frequently relapsing nephrotic syndrome.
11. 2 studies found an effect
on relapse rates, BUT
1st
study- small
number
2nd
study- did not
examine its long-
term benefit
12. RESEARCH QUESTION
Whether the strategy of short-term administration of small daily doses
of prednisolone during infectious illnesses was effective in reducing
annual relapse rates in patients with frequently relapsing Nephrotic
syndrome.
13. RESEARCH QUESTION
• P- Patients with frequently relapsing Nephrotic Syndrome
• I- Daily prednisolone
• C- Alternate day prednisolone
• O- Rate of infection associated relapse, frequency,
cumulative amount of prednisolone
• S- RCT
14. METHODOLOGY
Study design: randomized ,non blind, parallel group
Study site: Tertiary care hospital
Study subjects: Patients with idiopathic, frequently
relapsing nephrotic syndrome
Sample size: 100
Study period: September 2006 to October 2009 (Enrollment,
18 months)
Ethics committee clearance was taken
Written informed consent taken
15. Patients aged 1 to 16 years
Recently diagnosed frequently
relapsing nephrotic syndrome
(at least two relapses in 6
months or more than three
relapses in 12 months)
Impaired renal function (serum
creatinine > 1.2 mg/dl confirmed once
over a period of 2 weeks)
Intake of immunosuppressive
medications other than oral
prednisolone in the preceding 6
months
Steroid threshold exceeding 1 mg/kg
on alternate days for maintaining
remission and
one or more features of steroid
toxicity (BMI>95th percentile for
age, cataract, or stage 2
hypertension )
Inclusion criteria Exclusion Criteria
16. Frequently relapsing NS
1.5 mg/kg for 4 weeks,
f/b 0.25 mg/kg every 2 weeks until a dose of 0.5 to
0.75 mg/kg on alternate days was reached.
Prednisolone
STANDARD TREATMENT
If dose > 1mg/day to maintain
remission
If no steroid toxicity
Prednisolone + levamisole=2 mg/kg on alternate days
17. The presence of an INFECTION defined :
(1) fever: >38°C on 2 axillary temperature measurements at
least 1 hour apart
(2) Rhinorrhea or cough for more than 1 day
(3) Diarrhea (3 or more semiformed stools/d for 2 days)
INFECTION
Increase prednisolone
from alternate day to
daily dose for 7 days
Alternate day
prednisolone
Intervention group
Control group
18. RELAPSE DEFINITION AND MANAGEMENT
• Presence of 3 to 4 + proteinuria for 3 consecutive days after 7
days of the onset of an infectious illness
• Treatment:
– Prednisolone - 2 mg/kg per d until remission (trace/negative
protein for 3 consecutive days)
– 1.5 mg/kg; alternate days; 4 weeks and tapered.
Follow ups – Every 2 months for 1 year
Blood levels – (creatinine, albumin, cholesterol)
At enrollment, 6 months & 12 months
19. SERIOUS INFECTIONS
Lower respiratory tract infection, peritonitis, and
cellulitis - Hospitalized
Both groups were treated with
prednisolone (0.5 mg/kg per d orally) or an equivalent
IV hydrocortisone during therapy
21. SAMPLE SIZE
Relapse rate = 4.6+1.4 relapses/year
power - 80%
alpha error - 5%
dropout rate -10%.
to show 50% reduction in frequency of infection-associated relapses
n = 50 (each group)
22. STATISTICALANALYSIS
• Stata, version 9.1
• Intention to treat
• Incidence (relapse) density rates and rate differences calculated
• Poisson regression: compare relapse rates
• One-way ANOVA: assess the association between the number
of relapses and infections
• On the basis of the rate ratio, the number needed to be treat to
reduce the frequency of relapses to less than three per year
23. INCIDENCE DENSITY RATES
The incidence rate is the number of new cases per population
in a given time period.
When the denominator is the sum of the person-time of the at
risk population, it is also known as the incidence density rate
or person-time incidence rate.
24. EXAMPLE OF RELAPSE RATES
If a population initially contains 1,000 pts and 14
develop a condition over 1 year of observation
The Relapse rate is 14 cases per 1000 person-years
14 relapses would be expected for 1000 children observed for 1
year
25. RATE RATIO
Calculated to compare the ratio of events occurring at any given
point in time.
Rate Ratio = Incidence Rate 1/Incidence Rate 2
26. NUMBER NEEDED TO TREAT
The number of patients that need to be treated for one to
benefit compared with a control.
1/ARR
The ideal NNT is 1, where everyone has improved with
treatment and no-one has with control.
The higher the NNT, the less effective is the treatment.
29. 68 patients alternate-day prednisolone alone (strata 1)
32 received alternate-day prednisolone and levamisole (strata 2)
30.
31. 44 relapses (31 infection-associated) intervention group
76 (56 infection-associated) in the controls.
32.
33.
34. ADJUSTED ANALYSIS & NUMBER NEEDED TO
TREAT
Mean numbers of relapses per infection
Intervention 0.13+0.1
Control groups 0.35+0.2
Mean difference 0.22 (95% CI 0.16, 0.28) (P=0.04).
Poisson regression - daily administration of prednisolone during
infections independently resulted in a 59% reduction in the rate
of relapses (rate ratio, 0.41; 95% CI 0.3, 0.6).
Reduces frequency of relapses to less than 3 per yr
For every one out of six patients with frequent relapses
35. TREATMENT FAILURES AND ADD ON THERAPY
• Treatment failures
• 2 intervention group (at 6- and 10-month follow-ups)
• four control group (1 at 6-months & 3 at 9-month follow-up)
• Treated
– cyclophosphamide (n=2) or calcineurin inhibitors (n=4)
• Enalapril for stage 1 hypertension.
– 0.2 mg/kg/d
– 1 patient intervention group & 2 patients control group
37. DISCUSSION
With follow-up over 1 year, showed daily administration
during inter current infections
reduced relapse rates by almost one-half
higher proportion of patients with sustained remission.
1 of every 6 patients receiving intervention showed
infrequent relapses,
Reduction in relapse rates chiefly due to a reduced number
of infection-associated relapses.
Seventy percent relapses intervention group and 74%
controls preceded by infections, chiefly URI
38. PREVIOUS STUDIES
• Mattoo et al from Saudi Arabia,
• n=36
– patients with steroid-dependent nephrotic syndrome
– prednisone maintenance dose of 0.5 mg/kg on alternate days
• Alternate patients allocated to either
– receive daily prednisone for 5 days during URI or
– continue on alternate-day prednisone.
• At a 2-year follow-up,
– significant reduction in relapse rates in daily prednisolone.
• Limitations
– small number
– not randomized
– did not provide estimates of infections and prednisone dosage in the two
groups.
39. PREVIOUS STUDIES
Randomized, placebo-controlled trial from Sri Lanka
n=48 patients
steroid-dependent nephrotic syndrome receiving long-term treatment with
low-dose (<0.6 mg/kg), alternate-day prednisolone
Allocated to
receive prednisolone or placebo daily, for 7 days at the first sign of an
URTI.
Therapy switched during the second infectious illness.
Significantly lower relapse with daily therapy
Limitations
Patients observed for two consecutive infections
The effect of the intervention on the long-term unclear.
40. INFECTIONS
Number of infections
226 Intervention group
161 Control Group (P<0.04).
92% URI
6% gastroenteritis
2% fever without any localizing signs
41. MORE INFECTIONS IN INTERVENTION GROUP!
Precise reason unclear
Included four patients, each with 12 to 14 URI episodes
Mild and self-limiting
Did not require antibiotic therapy.
Did not appear to be related to steroids
Trend toward lower cumulative steroid dose in the
intervention group.
The risk of serious infections that required hospitalization &
corticosteroid side effects similar in both groups
42. Lack of a placebo arm
Although adequate allocation concealment before
randomization
subsequently physicians aware of the allocation
potential for bias.
Diagnosis of infection was clinical
no efforts for virological or bacteriological
confirmation
Judgment of excluding allergies on the basis of clinical
presentation, past patient history, and family history.
LIMITATIONS
43. LIMITATIONS
Subjects with mild courses of nephrotic syndrome.
Difficult nephrotic syndrome with a prolonged duration of disease
or high steroid threshold or those showing steroid toxicity
excluded.
Steroid threshold in this study was 0.5 to 0.75 mg/kg every other
day
Unclear whether this intervention useful in patients with a
lower steroid threshold
Similar benefits in patients co treated with other
immunosuppressive agents, e.g., MMF or CNI
Effect in patients from developed countries & in populations where
infections don't constitute a major cause for relapses of nephrotic
syndrome unclear
45. Section/topic Checklist item Comment
Title & abstract Identification as a randomised trial in the
title
Mentioned
Structured summary of trial design,
methods, results, and conclusions
Mentioned
Introduction
Background & objective Scientific background and explanation of
rationale
Mentioned
Specific objectives or hypotheses
Mentioned
Methods
Trial design Description of trial design (such as parallel,
factorial) including allocation ratio
Mentioned
Important changes to methods after trial
commencement (such as eligibility criteria),
with reasons
Not applicable
46. Section/topic Checklist item Comment
participants Eligibility criteria for participants
Mentioned
Settings and locations where the data
were collected
Tertiary care hospital
Interventions
The interventions for each group with
sufficient details to allow replication,
including how and when they were
actually administered
Mentioned
Outcomes Completely defined pre-specified primary
and secondary outcome measures,
including how and when they were
assessed
Mentioned
Any changes to trial outcomes after the
trial commenced, with reasons
None
Sample size How sample size was determined
50 in each group.
power-80%, α error-
5%, drop out-10%
When applicable, explanation of any
interim analyses and stopping guidelines
None
47. Section/topic Checklist item Comment
Randomization
Sequence generation
Method used to generate the random
allocation sequence
Mentioned
Type of randomisation; details of any
restriction (such as blocking and block
size)
Stratified
randomisation
Allocation concealment
mechanism
Mechanism used to implement the
random allocation sequence (such as
sequentially numbered containers),
describing any steps taken to conceal the
sequence until interventions were
assigned
Opaque sealed envelops
Implementation Who generated the random allocation
sequence, who enrolled participants, and
who assigned participants to interventions
Not mentioned
Blinding If done, who was blinded after assignment
to interventions (for example, participants,
care providers, those assessing
outcomes) and how
Not done
If relevant, description of the similarity of
interventions
not mentioned
Statistical methods Statistical methods used to compare
groups for primary and secondary
outcomes
Mentioned
Methods for additional analyses, such as
subgroup analyses and adjusted analyses
Subgroup analysis done
48. Section/topic Checklist item Comment
Results For each group, the numbers of
participants who were randomly assigned,
received intended treatment, and were
analysed for the primary outcome
Mentioned
Participant flow For each group, losses and exclusions
after randomisation, together with reasons
Mentioned
Recruitment Dates defining the periods of recruitment
and follow-up
Mentioned
Why the trial ended or was stopped
Not applicable
Baseline data A table showing baseline demographic and
clinical characteristics for each group
Table 1
Number analyzed For each group, number of participants
(denominator) included in each analysis
and whether the analysis was by original
assigned groups
Mentioned
Outcomes & estimation For each primary and secondary outcome,
results for each group, and the estimated
effect size and its precision (such as 95%
confidence interval)
Mentioned
For binary outcomes, presentation of both
absolute and relative effect sizes is
recommended
-
49. CONCLUSION
Daily administration of maintenance doses of prednisolone,
during intercurrent infections, significantly reduces relapse
rates and the proportion of children with frequently
relapsing nephrotic syndrome.
Editor's Notes
The cause of nephrotic syndrome can be idiopathic (primary glomerular disease) or secondary to chronic systemic diseases (e.g., diabetes mellitus, amyloidosis, sickle cell anemia,18 lupus), cancer (e.g., multiple myeloma, Hodgkin’s disease), infections (e.g., HIV,19 hepatitisB, syphilis, malaria), intravenous (IV) drug abuse, and edications (e.g., gold, penicillamine, captopril, nonsteroidal
anti-inflammatory drugs [NSAID]
Steroid dependence- Two consecutive relapses when on alternate day steroids or within 14 days of its discontinuation.
Steroid resistance- Absence of remission despite therapy with daily prednisolone at a dose of 2 mg/kg per day for 4 weeks.
To test the hypothesis that
primary outcome was assessed by comparing
the rates of infection-associated relapses (relapses occurring
in the week after the 7-day intervention period)
and expressed as episodes/patient per yr. Secondary
outcomes included the frequency and type of
infections and the cumulative amount of prednisolone
received in both groups. The occurrence of
two or more relapses in any 6-month period was
considered treatment failure. These patients exited
the study and were treated using alternative medications.