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Greet Van den Berghe, M.D., Ph.D., Alexander Wilmer, M.D., Ph.D., Greet Hermans, M.D., Wouter Meersseman, M.D., Pieter J. Wouters, M.Sc., Ilse Milants, R.N., Eric Van Wijngaerden, M.D., Ph.D., Herman Bobbaers, M.D., Ph.D., and Roger Bouillon, M.D., Ph.D.
Background ,[object Object]
Introduction ,[object Object]
Introduction ,[object Object],[object Object],[object Object]
[object Object],[object Object],Introduction
Methods ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Design ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conventional Treatment Group ,[object Object],[object Object]
Intensive Treatment Group ,[object Object],[object Object]
 
Outcome Measures ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Outcome Measures ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Secondary Outcome
 
Results ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results Hypoglycemia
Morbidity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
Morbidity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
Stays in ICU Longer Than Three Days ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
 
[object Object],[object Object],[object Object],Results Stays in ICU Longer Than Three Days
[object Object],[object Object],Results Stays in ICU Longer Than Three Days
[object Object],[object Object],Results Stays in ICU Longer Than Three Days
[object Object],[object Object],[object Object],Results Stays in ICU Longer Than Three Days
Mortality ,[object Object],[object Object],[object Object],Results
Mortality ,[object Object],[object Object],Results
 
Mortality ,[object Object],[object Object],[object Object],Results
Discussion ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],Discussion The reduced morbidity in patients who received intensive insulin therapy as compared with those who did not resulted  from
[object Object],[object Object],[object Object],Discussion
[object Object],[object Object],[object Object],Discussion
Limitations ,[object Object],[object Object]
Conclusion  ,[object Object],[object Object]
Recommendations ,[object Object],[object Object]
Recent studies  ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Results Recent studies
[object Object],[object Object],Recent studies
On going study  ,[object Object],[object Object]
A Multi-Center, Open Label Randomized Stratified Controlled Trial of the Effects of Blood Glucose Management on 90-Day All-Cause Mortality in a Heterogenous Population of  Intensive Care  Unit (ICU)  Patients Purpose  The primary aim of the study is to compare the effects of the two blood glucose targets on 90 day all-cause mortality in Intensive Care patients who are predicted on admission to stay in the ICU for at least one full calendar day The hypothesis  is that there is little difference in the relative risk of death between patients assigned a glucose range of 4.5 - 6.0 mmol/L, and those assigned a glucose range of less than 10.0 mmol/L with insulin being infused if blood glucose exceeds 10.0 mmol/L, and adjusted when needed to maintain blood glucose of 8.0 - 10.0 mmol/L On going study
 

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Intensive Insulin Therapy In The Medical ICU

  • 1. Greet Van den Berghe, M.D., Ph.D., Alexander Wilmer, M.D., Ph.D., Greet Hermans, M.D., Wouter Meersseman, M.D., Pieter J. Wouters, M.Sc., Ilse Milants, R.N., Eric Van Wijngaerden, M.D., Ph.D., Herman Bobbaers, M.D., Ph.D., and Roger Bouillon, M.D., Ph.D.
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  • 39. A Multi-Center, Open Label Randomized Stratified Controlled Trial of the Effects of Blood Glucose Management on 90-Day All-Cause Mortality in a Heterogenous Population of Intensive Care Unit (ICU) Patients Purpose The primary aim of the study is to compare the effects of the two blood glucose targets on 90 day all-cause mortality in Intensive Care patients who are predicted on admission to stay in the ICU for at least one full calendar day The hypothesis is that there is little difference in the relative risk of death between patients assigned a glucose range of 4.5 - 6.0 mmol/L, and those assigned a glucose range of less than 10.0 mmol/L with insulin being infused if blood glucose exceeds 10.0 mmol/L, and adjusted when needed to maintain blood glucose of 8.0 - 10.0 mmol/L On going study
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