This document discusses iron storage and transport in the human body. It describes how ferritin is an iron storage protein that stores iron in a safe form and releases it when needed. Transferrin is also discussed as a transport protein that carries iron through the bloodstream and delivers it to tissues. The document emphasizes the crucial role of iron in transporting oxygen via hemoglobin in red blood cells. Maintaining adequate iron levels is important to prevent deficiencies or anemia, though the body continually loses small amounts of iron through normal processes.

1. Iron storage protein

2. Content.
• Introduction
• The crucial role of iron in the body.
• Iron disorder
• Ferritin: The iron storage protein
• Transferrin
• Clinical importance of iron

3. Iron storage protien.
• Introduction:
• What are our bodies made of, and how do they
work?
• These questions are fudamental to the study of
medicine and to many chemists, biologists, and
engineers.
• We know that our bodies are matter, and thus must
be composed of atoms that have been specially
arranged to produce the molecules and larger
structures that sustain our lives.

4. Continue...
• We know that the properties of an atom (e.g.,size,
electronegativity, number of valence electrons)
determine how that atom will interact with other
atoms.
• The largest elemental components of the body,mass,
are oxygen(65%), carbon(18%), hydrogen elements in
the body, such as calcium, phosphorus, iron, and
copper, are known to physiologists as minera
elements and trace elements.

5. The crucial role of iron in the
body:
• The iron is necessary for oxygen transport in the
blood.
• Recall that iron is the central atom of heme group,
a metal complex that binds molecular oxygen in the
lungs and carries it to all of the other cells in the
body ( e.g., the muscles) that need oxygen to
perform their activities.

6. Continue...
• Without iron in the heme group, there would be no
site for tha oxygen to bind, and thus no oxygen
would be delivered to the cells(which would result
in the cells dying).

7. Iron disorders
• Because iron plays such a crucial role in the body, it is
important for us to mantain an adequate supply of
iron to form hemoglobin .and the other molecules in
the body that depend on iron to function properly.
• Yet, our bodies continually lose iron (in small
amounts) through everyday process such as
urination, defection, sweating, and sloughing off skin
cells.

8. Continue...
• When the body's supply of available iron is too low, a
conditon known as iron deficiency results.
• People with iron deficiency cannot produce an
adequate amount of hemoglobin to meet their
body's oxygen transport needs.
• When the deficiency becomes severe(so that there
are too few circulating red blood cells or the
hemoglobin content of these cells is very low)the
condition is diagnosed as iron-deficiency anemia.

9. Ferritin: The iron storage protein
• Ferritin is protein that stores iron and releases it in
a controlled fashion.
• Hence, the body has a "buffer" against iron
deficiency(if the blood has too little iron,ferritin can
release more) and, to a lesser extent, iron
overload(if the blood and tissues of the body have
too much iron, Ferritin can help to store the excess
iron).

10. Continue...
• Ferritin serves to store iron in a non- toxic form,to
deposit it in a safe form, and to transport it to areas
where it is required.
• The function and structure of the expressed ferritin
protien varies in different cell types.

11. Transferrin:
• The role of trasferrin as a vehicle for the transport
of iron begins with the synthesis and secretion of
the glycoprotein moecule by tissues such as the
live, continues with the acquisition of a maximum
of two atoms of ferric iron, and terminates with the
delivery of this essential element to a variety of
body tissues.

12. Continue...
• The intracellular iron cycle can be thought of as
consisting of two arms.
• The endocytotic arm begins with the internalisation
of the membrane receptor fuses back into the lipid
bilayer whilst the apotransferrinis released into the
extracellular fluid.

13. Clinical importance of iron:
• Iron is essential element for blood production.
• About 70% of iron is found in the red cells of our
blood called hemoglobin and in muscle cells called
myoglobin.
• About 6 percent of body iron is a component of
certain proteins, essential for respiration and
energy metabolism.

14. Continue...
• About 25 percent of the iron in the body is stored
as ferritin, found in cells and circulates in the blood.
• The average adult male has about 1,000 mg of
stored iron(enough for about three years), whereas
women on average have only about 300 mg ,(
enough for about six months).

15. • Thank you 😃