Cytochrome is an electron transferring protein containing a heme group. There are different types of cytochromes which contain different groups attached to the heme. Cytochrome C specifically is attached to the inner mitochondrial membrane and plays a key role in electron transfer as part of the electron transport chain and ATP production. The electron transport chain involves several protein complexes including Complex III which contains cytochromes B and C, and Complex IV or cytochrome C oxidase which uses cytochrome C to shuffle electrons into oxygen molecules.

1. Cytochrome
Feroze Hussain (8828)
Presented by
DEPARTMENT OF CHEMISTRY
CENTRAL UNIVERSITY OF HARYANA
M.Sc. 3rd semester
110/27/2017

2. Content
 Introduction
 Types
 Cytochrome C
 Role of Cytochrome
 Conclusions
References
 Acknowledgement 210/27/2017

3. Cytochrome
Color
Protein
Heme group
Transfer electron
310/27/2017

4. Heme group
N
N
N
N
H
H
410/27/2017

5. Heme group
510/27/2017

6. Heme types
Heme A:
R1= CH CH2
R2= C18H30OH
Heme B
R1=R2=CH CH2
Heme C
R1=R2= CH(CH3)S Protein
610/27/2017

7. Cytochrome types
A B C 710/27/2017

8. Cytochrome C
 Heme- protein attached with inner-
mitochondrial membrane
 Higly water soluble
 Redox
 Electron transfer in Complexes
810/27/2017

9. Distribution
 In animals, plants, and unicellular organisms
 In Plants – ETC
 In animals – ETC
 Evolutionary Biology
910/27/2017

10. Structure
 Heme group has polypeptide
chain wrapped around it
Contains Variable number of
Amino acids
 Nitrogen atom from histidine
and a Sulfur atom from
methionine segment are
coordinated with Iron atom
1010/27/2017

11. Cytochrome-C-Oxidase
 Uses metal to shuffle electron
into oxygen molecule
4 Fe2+-cytochrome c + 8 H+
in + O2 → 4 Fe3+-
cytochrome c + 2 H2O + 4 H+
out
1110/27/2017

12. Power House Of The Cell
 Semi- autonomous cell Organelle.
 Electron Transport Chain
1210/27/2017

13. Electron Transport Chain
1310/27/2017

14. Complex 3rd
 Also called cyt bc1 complex
 Has cyt B and Cyt C
 Cyt B has Heme B
 Cyt c has Heme C
 Reskie iron sulfur also
present 1410/27/2017

15. Complex 4th
 Also known as cyt a complex
 Has various subunits
 Subunit 1: heme groups
and Cu ion
 Subunit 2: Has 2 Cu ion
 Subunit 3: role not clear but
important for the functioning of this complex
1510/27/2017

16. Conclusions
1610/27/2017
 Electron transferring protein
 Cytochrome types differ by attachment of different
groups
 Cytochrome found in all sort of life
 Mitochondria in which cytochrome plays its role
 Electron transport chain
 complexes involves in the ETC
 ATP

17. References
 Inorganic chemistry ; James E. Hueey, 663-666.
 GOOGLE
 Principles of Biochemistry ; David L.Nelson
1710/27/2017

18. Acknowledgement
Dr. Prakash Kanoo
Dr. Manoj Kumar Gupta
1810/27/2017

19. 1910/27/2017