ABSTRACT
Azadirachta indica common name Neem is a very useful traditional medicinal plant in the sub-continent and each part of the tree has some medicinal properties. It has many therapeutic properties as it boosts the immune system, beneficial in treating acne, provides relief from bad breath, helps to protect against diabetes, effective in treating malaria symptoms, lowers the risk of cancer and cardiovascular disease. The plant is native to Asia and its sub-continents. Therefore, the aim of the present study was to investigate the phytochemical constituents present in leaves and bark of neem. The antioxidant activity, total phenolic, and flavonoid contents were also evaluated. Neem leaves and bark were collected from the Bundelkhand University Campus, Jhansi. It was cleaned with tap water and finally with distilled water and was air dried at room temperature and crushed. TLC was done for the determination of bioactive compounds present in the leaves. A qualitative phytochemical analysis was performed and we found that alkaloids, reducing sugar, flavonoids, glycosides, tannins, phenolic compounds, saponins are present in neem leaves and bark. TLC results shown total 8 spots in the methanolic leaves extract having different Rf values. The total antioxidant capacity of A. indica leaves shown the dose dependent activities. The mean values of total phenolic contents and flavonoids are 70 mg GAE/g & 119 mg QE/g respectively. Thus in the present study, the presence of flavonoids and phenolic compounds in the neem leaves extract could be considered responsible for conferring antioxidant ability.
Key-words: Phytochemical, Azadirachta indica, Antioxidant Activity, Total Phenolic Content (TPC), Total Flavonoids Content (TFC)
ANTI - INFLAMMATORY ACTIVITY OF LEAVES OF JATROPHA GOSSYPIFOLIA L.Raju Sanghvi
BY HRBC MEMBRANE STABILIZATION METHOD, Introduction, Preparation of extracts, Chemicals and instruments, In vitro anti – inflammatory activity, Acute oral toxicity study, Discussion
Antimicrobial activity of herbal productionkarimbscdu
The use of plants in treatment of burns, dermatophytes and infectious diseases is common in traditional medicine. The development of new antimicrobial agents against resistant pathogens is increasing interest. Therefore, the methanolic extracts from different parts of four medicinal plants used locally in folk medicine were evaluated for antimicrobial activity. It was found that most plant extracts studied had antibacterial and antifungal activities. The methanolic extract of leaf of the plant Azadiracta indica, Acacia nilotica and Witania somnifera showed significant antibacterial activity against Bacillus subtilis, Escherchia coli, stphaylocuccus aureus and pseudomonas fluorescence. Azadiracta indica and A.tinolica showed significant antifungal activity against A. flavus, Ziziphus mauritiana. The rhizome extract of curcuma longa showed significant activity against all tested bacteria and showed higher anti fungal activity against Fusarium verticillioides
Oxygen is highly reactive atom that is capable of becoming part
of potentially damaging molecule commonly called “free radical.”
Free radicals are capable of attacking cells of the body, causing
them to lose their structure and function.
Free radicals have been implicated in the pathogenesis of at
least 50 diseases.
Free radial formation is controlled naturally by various compounds
known as antioxidants.
It is when the ability of antioxidant is limited that this damage can
become cumulative and debilitating.
Following criteria should be considered while selecting an antioxidant.
It should be able to produce desire redox reaction.
It should be physiologically and chemically compatible.
It should be physiologically inert.
It should be non-toxic both in the reduced and oxidized forms.
It should be effective in low concentration.
It should provide prolonged stability to the formulation.
Phytochemical and anti proliferative activity of Nigella sativa (Kalonji)Saptarshi Samajdar
Highly potent plant having very useful pharmacological effect especially in anticancer studies and various other diseases. It is even called Panacea because it can cure all diseases except death. Various religious books mention its existence as potent herbal drug.
Studies that examined the therapeutic potential of plants leaf extracts
Plant Scientific Name Common Name Type of extraction Proposed active material
1. Solanum viarum Tropical Soda Apple Ether Solasodine glycoalkaloid
2. Acanthus illicifolious Harkucha Kanta Methanol Triterpenoids,Flavonoids,
Alkaloids
3. Annona squamosa Custard Apple Ethyl acetate Acetogenins,Alkaloids,
Dofamine
4 Alstonia scholaris. Chatium Methanol Alkaloids,Flavonoids
5. Calotropis gigantea Akanda Ethanol Triterpenoids,Flavonol
Glycosides
Definition of drug interaction, potential of herb-drug interactions,significance of study of herb-drug interactions, reasons for their study, types according to ayurveda, effects & different ways of herb-drug interactions, their mechanism, hypericum, kava lava, ginkgo biloba, ginseng, garlic, pepper, ephedra.
ABSTRACT- Background: Spinacia oleracea L. commonly known as palak is an edible flowering plant belongs to Amaranthaceae family. The plants exhibit its curative activity against several human diseases because of the presence of biological tannins and phenolic active phytochemicals such as alkaloids, flavonoids, steroids, glycosides, terpenoids. It is used in the treatment of difficulty in breathing, inflammation of liver and lungs and leucorrhoea, useful in urinary concretion, inflammation of the lungs, sore throat, and pain in joints. Materials and Methods: Spinacia oleracea L. was collected from local market Jhansi in the month of January 2017. Aqueous and methanolic extraction of Spinacia oleracea L. and phytochemical screening of the extracts was done for Saponins, Reducing sugar, Cardiac glycosides, Protein and Amino acid, Glycosides, Alkaloids, Tannins, Flavonoids, Terpenoids, and Steroids. Results: Phytochemical analysis of leaves of S. oleracea had most of the important phytochemicals like Alkaloids, Tannins, Glycosides, Terpenoids, and Flavonoids etc. In which, the aqueous extract of S. oleracea showed (in most of the test) positive result for Alkaloids, Phenols, Flavanoids, Saponins, Terpenoids, Reducing sugar, Protein, and Amino acid and showed a negative result for Carbohydrate, Glycosides, and Cardiac glycosides. The methanolic extract of the plant leaves revealed the presence of (in most of the test) Alkaloids, Tannins & Phenolic compounds, Flavanoids, Saponins, Terpenoids and Steroids and negative results for the rest. Conclusions: The phytochemical analysis of S. oleraceae revealed the presence of phytochemicals such as, Tannins, Flavonoids, Alkaloids, Saponins, and Terpenoids etc. in the different extracts. By the presence of these phytochemicals, we were suggested that S. oleracea is a good nutrient rich leafy vegetable that can be used as a therapeutic and curative medicine for many oxidative stress- induced diseases. Key-words- Phytochemical analysis, Spinacia oleracea, Flavonoids, Alkaloids, Terpenoids, Methanolic extract
ANTI - INFLAMMATORY ACTIVITY OF LEAVES OF JATROPHA GOSSYPIFOLIA L.Raju Sanghvi
BY HRBC MEMBRANE STABILIZATION METHOD, Introduction, Preparation of extracts, Chemicals and instruments, In vitro anti – inflammatory activity, Acute oral toxicity study, Discussion
Antimicrobial activity of herbal productionkarimbscdu
The use of plants in treatment of burns, dermatophytes and infectious diseases is common in traditional medicine. The development of new antimicrobial agents against resistant pathogens is increasing interest. Therefore, the methanolic extracts from different parts of four medicinal plants used locally in folk medicine were evaluated for antimicrobial activity. It was found that most plant extracts studied had antibacterial and antifungal activities. The methanolic extract of leaf of the plant Azadiracta indica, Acacia nilotica and Witania somnifera showed significant antibacterial activity against Bacillus subtilis, Escherchia coli, stphaylocuccus aureus and pseudomonas fluorescence. Azadiracta indica and A.tinolica showed significant antifungal activity against A. flavus, Ziziphus mauritiana. The rhizome extract of curcuma longa showed significant activity against all tested bacteria and showed higher anti fungal activity against Fusarium verticillioides
Oxygen is highly reactive atom that is capable of becoming part
of potentially damaging molecule commonly called “free radical.”
Free radicals are capable of attacking cells of the body, causing
them to lose their structure and function.
Free radicals have been implicated in the pathogenesis of at
least 50 diseases.
Free radial formation is controlled naturally by various compounds
known as antioxidants.
It is when the ability of antioxidant is limited that this damage can
become cumulative and debilitating.
Following criteria should be considered while selecting an antioxidant.
It should be able to produce desire redox reaction.
It should be physiologically and chemically compatible.
It should be physiologically inert.
It should be non-toxic both in the reduced and oxidized forms.
It should be effective in low concentration.
It should provide prolonged stability to the formulation.
Phytochemical and anti proliferative activity of Nigella sativa (Kalonji)Saptarshi Samajdar
Highly potent plant having very useful pharmacological effect especially in anticancer studies and various other diseases. It is even called Panacea because it can cure all diseases except death. Various religious books mention its existence as potent herbal drug.
Studies that examined the therapeutic potential of plants leaf extracts
Plant Scientific Name Common Name Type of extraction Proposed active material
1. Solanum viarum Tropical Soda Apple Ether Solasodine glycoalkaloid
2. Acanthus illicifolious Harkucha Kanta Methanol Triterpenoids,Flavonoids,
Alkaloids
3. Annona squamosa Custard Apple Ethyl acetate Acetogenins,Alkaloids,
Dofamine
4 Alstonia scholaris. Chatium Methanol Alkaloids,Flavonoids
5. Calotropis gigantea Akanda Ethanol Triterpenoids,Flavonol
Glycosides
Definition of drug interaction, potential of herb-drug interactions,significance of study of herb-drug interactions, reasons for their study, types according to ayurveda, effects & different ways of herb-drug interactions, their mechanism, hypericum, kava lava, ginkgo biloba, ginseng, garlic, pepper, ephedra.
ABSTRACT- Background: Spinacia oleracea L. commonly known as palak is an edible flowering plant belongs to Amaranthaceae family. The plants exhibit its curative activity against several human diseases because of the presence of biological tannins and phenolic active phytochemicals such as alkaloids, flavonoids, steroids, glycosides, terpenoids. It is used in the treatment of difficulty in breathing, inflammation of liver and lungs and leucorrhoea, useful in urinary concretion, inflammation of the lungs, sore throat, and pain in joints. Materials and Methods: Spinacia oleracea L. was collected from local market Jhansi in the month of January 2017. Aqueous and methanolic extraction of Spinacia oleracea L. and phytochemical screening of the extracts was done for Saponins, Reducing sugar, Cardiac glycosides, Protein and Amino acid, Glycosides, Alkaloids, Tannins, Flavonoids, Terpenoids, and Steroids. Results: Phytochemical analysis of leaves of S. oleracea had most of the important phytochemicals like Alkaloids, Tannins, Glycosides, Terpenoids, and Flavonoids etc. In which, the aqueous extract of S. oleracea showed (in most of the test) positive result for Alkaloids, Phenols, Flavanoids, Saponins, Terpenoids, Reducing sugar, Protein, and Amino acid and showed a negative result for Carbohydrate, Glycosides, and Cardiac glycosides. The methanolic extract of the plant leaves revealed the presence of (in most of the test) Alkaloids, Tannins & Phenolic compounds, Flavanoids, Saponins, Terpenoids and Steroids and negative results for the rest. Conclusions: The phytochemical analysis of S. oleraceae revealed the presence of phytochemicals such as, Tannins, Flavonoids, Alkaloids, Saponins, and Terpenoids etc. in the different extracts. By the presence of these phytochemicals, we were suggested that S. oleracea is a good nutrient rich leafy vegetable that can be used as a therapeutic and curative medicine for many oxidative stress- induced diseases. Key-words- Phytochemical analysis, Spinacia oleracea, Flavonoids, Alkaloids, Terpenoids, Methanolic extract
A Preliminary Study on Phytochemical Screening of Boerhaavia Diffusa, Euphorb...ijtsrd
Medicinal plants are of great importance to the health of individuals and communities. The medicinal value of these plants lies in some chemical substances that produce a definite physiological action on the human body. The objective of the present study was to evaluate the phytochemical constitution and antioxidant activity of Aqueous extracts of three selected plant Boerhaavia diffusa, Euphorbia hirta and Amaranthus polygonoides. Preliminary phytochemical screening revealed the presence of phytochemicals like alkaloids, flavonoids, Steroids, phenols, tannin and carbohydrates in Boerhaavia diffusa and Euphorbia hirta where as in Amaranthus polygon ides many phytoconstituents like alkaloids, flavonoids, Steroids, terpenoids, phenols, saponin, tannin and carbohydrates were present. Antioxidants are the compounds which terminate the attack of reactive species and reduce the risk of diseases. The free radicals oxidants are species with very short half life, high reactivity and damaging activity towards macromolecules like proteins, DNA and lipids. The results of antioxidant activity of three aqueous extract showed maximum activity in different concentration of 50, 250, 500, 750 and 1000 µg ml. The percent inhibition of aqueous extract of Boerhavia diffusa , Euphorbia hirta , Amaranthus polygonoides was 176.15, 404.78 and 413.06 respectively. In the present work potent anti oxidant activity of aqueous extract of Boerhaavia diffusa was higher when compared to other two extracts. The present study revealed that the plant extract possessed good antioxidant activity and less quantity of toxic metals, which therefore can be used as a natural source of free radical scavenger. However, further study needs to be carried out to know its mode of action. R. Ezhilarasi | Dr. B. Senthilkumar | Dr. K. Devi "A Preliminary Study on Phytochemical Screening of Boerhaavia Diffusa, Euphorbia Hirta and Amaranthus Polygonoides" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29435.pdfPaper URL: https://www.ijtsrd.com/biological-science/zoology/29435/a-preliminary-study-on-phytochemical-screening-of-boerhaavia-diffusa-euphorbia-hirta-and-amaranthus-polygonoides/r-ezhilarasi
THE ANTIOXIDANT ACTIVITY OF DIFFERENT SOLVENT EXTRACTS OF LEAVES AND BARK OF ...adeij1
In this work we have find out the antioxidants activity of the ethyl acetate, methanolic and aquaous extract of leaves and bark of Baccaurea ramiflora (Lour.). The antioxidant activity of the extracts was measured by in vitro chemical analyses involving the assays of (1) Au nanoparticle formation potential (2) 1,1-diphenyl2-picrylhydrazyl (DPPH) radical scavenging activity (3) ferric ion reducing power and (4) ferrous ion chelating activity. A simpler method has been created based on Au nanoparticles formation to assess the antioxidant activity of any plant extract. It was for the assessment of the antioxidant activity of all the extract of leaves and bark of Baccaurea ramiflora (Lour.). In all the assays, methanolic extract of leaves of Baccaurea ramiflora (MEBRL) and methanolic extract of bark of Baccaurea ramiflora (MEBRB) showed significantly greater activity over other extracts. This work provides a scientific support for the high antioxidant activity of this plant and thus it may find potential applications in the treatment of the diseases caused by ROS.
Neem Azadirachta indica has much importance. Usefulness of neem has already mentioned in several literature. Ayurveda has mentioned its use in many disease conditions. Now public awareness for herbal products are increasing highly so it has been found demand of neem products are increasing day by day. Neem is a plant who's every parts holds multiple usage. Researcher has reported many medicinal benefits of neem. Neem is known for its anti diabetic, anti inflammatory, anti cancer effect. Neem is used in many hindu rituals. This review work represents several usage of neem which will provide a great knowledge to people and let them know about the wonder of neem. Rudra Prasad Giri | Dr. Ajit. K. Gangawane | Dr. Sucheta Ghorai Giri ""Neem the Wonder Herb: A Short Review"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23038.pdf
Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/23038/neem-the-wonder-herb-a-short-review/rudra-prasad-giri
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
Antioxidant activity of Hedera helix L. extracts and the main phyto constituentspharmaindexing
The present study was carried out to evaluate antioxidant activity of Hedera helix stems extracts and also to investigate the main phytoconstituents in the bio-active extract. N-hexane, dichloromethane, ethyl acetate and methanol 80% extract were tested for free radical scavenging activity on model reaction with stable 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The results showed that ethyl acetate was the most active one as antioxidant agent and phytochemical analysis of that extract revealed the presence of triterpenes, saponins, flavonoids, tannins and carbohydrates. The results suggest new chemical classes of natural antioxidant substances that could serve as selective agents for infectious diseases.
Phytochemical screening and antimicrobial activity evaluation of aqueous and ...Premier Publishers
Azadirachta indica Juss (neem) is a plant which has been used for a long time as traditional medicine for household remedy against various human ailments from antiquity. To evaluate the scientific basis for the use of Azadirachta indica, both aqueous and ethanolic extracts of the dried leaves of the plant were subjected to phytochemical screening and determination of anti-microbial activity on six different species of bacteria and a fungus. The phytochemical screening of the aqueous and ethanolic extracts of dried powdered leaves of the plant was done using standard methods. The antimicrobial activity of the concentrated extracts was evaluated by determination of the diameter of zone of inhibition against the microorganisms using agar well diffusion method. The Phytochemical screening of the test plant revealed the presence of saponins, alkaloids, cardiac glucosides, phenols, resins, tannins, terpenes and steroids. Although, both plant extracts had antimicrobial effects against the test organisms, the aqueous extracts were found to show greater anti-microbial effect than ethanolic extract. Thus, the mean diameter zones of inhibition ranged from 0.03mm-40.00mm for aqueous extract and 0.50mm-21.00mm for ethanolic extract at the highest concentration of 50mg/ml. The finding of this study supports the use of neem leaf in the treatment of various microbial infections by alternative systems of medicine.
The Medicinal Plant of Mimusops Elengi (Sapodaceae) in Antimicrobial ActivitiesIJERA Editor
The selected study area for this study is Pachaimalai Hills, situated in Eastern ghats of Tamil Nadu. This study
was focussed on the antimicrobial activity of Mimosopselengi, one of the medicinal plant belongs to the family
sapotaceae. It is a tropically distributed the highly medicinal plant. Antimicrobial activities and extracts of
petroleum ether, Ethyl acetate and methanol were also found to be better with respect to inhibitory function
against the two fungal species, Fusarium oxysporum and Aspergillus flavus. The study scientifically validates
the use of plant in traditional and ethno medicine. Three solvents such as Petroleum ether, Ethyl acetate and
Ethanol were used to take plant extract. These extracts were studied for antimicrobial activity against two gram
positive bacterial strains such as Bacillus substilis andBacillus thuriengensis and two gram negative bacterial
strains such as Klebsiella pneumonia and Escherichia coli. This study also extended to find antifungal activity
against four fungal strains
The Comparative Study of Antioxidant Activity Of Monsoon Plant-Clerodendrum S...inventionjournals
ABSTRACT: The increasing demands of convenient food have led to rapid growth in the ready-to-eat product category. Many of the food ingredients contain unsaturated fatty acids that are quite susceptible to quality deterioration, especially under oxidative stress. To combat this, the best strategy is addition of antioxidants. Also, natural antioxidants in the daily diet need to be encouraged in order to improve human health and prevent degenerative diseases like Alzheimer’s, coronary heart disease, neurogenetic disorders, cancer, atherosclerosis and inflammations by oxidation of proteins, lipids, nucleic acids, DNA, etc. The DPPH method of free radical scavenging was carried out and the effect of the commercial, fresh, dried and cooked sample of Clerodendrum serratum were compared and calculated to check for its antioxidant activity. All samples showed antioxidant activity, highest being in cooked, followed by commercial, fresh and dried samples. Thus, it is advisable to consume the vegetable in cooked form at home as it shows highest radical scavenging power. The dried samples were over-heated, thereby showing minimum antioxidant activity.
In vitro free radical scavenging activity of different extracts of Adansonia ...IJEAB
The species Adanasonia digitata L. (Bombacaceae) is a multipurpose tree with enormous range of medicinal and economic importance. The objective of the current study was to investigate the free radical scavenging potential of A. digitata. The methanol extracts of different parts i.e., leaf, seed, bark, fruit wall and floral extracts of A. digitata were screened for antioxidant activity using DPPH assay. Results from this study showed that the maximum and minimum percentage of free radical scavenging activity was exhibited by methanol extracts of seed and fruit wall (27.69 & 20) as measured by using DPPH assay. These results showed the antioxidant potential of this medicinal plant to make use in the preparation of drugs with free radical scavenging activity.
Studies on the Antioxidant Properties of Various extracts of Hippophae rhamnoideIJEAB
Sea Buckthorn (Hippophae rhamnoides) a spiny shrub native to Ladakh Region of Jammu and Kashmir, have been found to posses so many medicinal properties from times immoral. From this point of view the antioxidant property of the plant fruit extracts have been analysed by DPPH method. Various plant extracts viz, fruit, leaf and root have been analysed for the antioxidant power determination in which fruit extracts showed highest free radical scavenging activity followed by leaf and root extracts. Among the solvents which have been used, more polar solvents showed highest antioxidant activity than the less polar solvent extracts. The IC50 value of various plant extracts as determined have been found to be 40 for DCM extract of fruit, 38 for Methanolic extract of fruit and 30 for the water extract of fruit. Similarly the leaf extracts posses IC50 value as 51, 47 and 37 respectively for DCM, Methanol and Water extracts. The IC50 values of various root extracts have been found to be 53, 50 and 48 respectively for DCM, Methanol and Water.
Similar to Investigation of Total Phenolic, Flavonoid Contents and Antioxidant Activity from Extracts of Azadirachta indica of Bundelkhand Region (20)
Background: Cancer is a disease caused when cells divide uncontrollably and spread into the surrounding tissue. Changes to DNA cause cancer. It is one of the most common and largest killer diseases in the world. It usually affects physically, and the disease can alter one’s perspective on life and personality. Many treatment options are there to treat cancer. Among them, chemotherapy treatment may have more side effects like lethargy, esophagitis, nausea, vomiting, Fatigue, and insomnia, the most common problems among chemotherapy patients in India. Methods: A quasi-experimental study with a sample size of 60, out of which 30 subjects were in the experimental group and 30 were in the control group. A convenient sampling method was used to select the subjects. A structured questionnaire tool was used to collect the data. Result: The result of the study showed that, during pre-test in the study group, among 30 subjects 3(10%) had moderate Fatigue, 22(73.33%) had severe Fatigue, 5(16.67%) had worst Fatigue and 12(40%) had moderate insomnia, 18(60%) had severe insomnia and in control group among 30 subjects, 6(20%) had moderate Fatigue, 13(43.33%) had severe Fatigue, 11(36.67%) had a worst fatigue, and 14(46.67%) had moderate insomnia, 16(53.33%) had severe insomnia. With post-test, in experimental group, 14(46.67%) had no fatigue, 16(53.33%) had mild fatigue, 14(46.67%) had no insomnia, 16(53.33%) had mild insomnia, and in control group, 6(20%) had moderate fatigue, 13(43.33%) had extreme fatigue, 11(36.67%) had worst fatigue, and 14(46.67%) had moderate insomnia, 16(53.33%) had severe insomnia. Conclusion: The study concluded that clients who were receiving chemotherapy had fatigue and insomnia problems. The Warm water foot bath therapy is very effective in clients undergoing chemotherapy in reducing Fatigue and insomnia. A positive correlation between pre-test and post-test was found by using the Mann-Whitney test.
Key-words: Cancer, Chemotherapy, Foot bath, Health, Warm water
Background: Alcohol has long been a global social and medical issue. According to W.H.O report. Total 3.3 million people die from
alcohol abuse annually. Alcoholic liver disease (A.L.D.) ranges from steatosis to liver cirrhosis. Chronic heavy drinkers get hepatitis
or cirrhosis 15 20% of the time
Methods: This study was c onducted in the general medicine inpatient department at PGIMER & C . in Bhubaneswar, Odisha,
Indi a. All hospitali z ed patients with liver illness who had previously t aken alcohol were screened. Each patient's alcohol
consumption, including native alcoholic beverages, was recorded. To support the diagnosis, all standard and extra examination s
were carri ed out. The modified Kuppuswamy scale was used to determine s s ocioeconomic class.
Results: The study comprised 186 participants with a median age of 46. The gender ratio was 3:1, with 139 (74.7%) men. Urban
populations have a greater prevalence of alcohol ic liver disease (60.75%) than rural populations (39.24%). The l ower
s ocioeconomic c lass (50.53%) has the highest rate of alcoholic liver disease. Men drink more (>700 gm/wk) and married people
drink more. A woman who drinks 140 280 grams per week for 10 1 5 years is more likely to develop alcoholic liver disease than a
man who drinks >700 grams per week for 15 years.
Conclusions: In this study, we conclude d that the prevalence of A .L. about S .E. is of utmost importance in developing
population based st r ategies that effectively educate individuals on the need to modify their drinking habits. This is crucial to
mitigate the occurrence of alcohol consumption and its associated repercussions.
Key-words: Socioeconomic status, Hospitalized Patients, Alcoholic Liver Disease
Background: One of the most common disorders in this age group, abnormal uterine bleeding (AUB), is the primary cause of most gynaecological problems in adolescents. Unfortunately, epidemiological data on AUB in teenagers is scarce, especially in the Indian subcontinent. The PALM-COEIN classification, where PALM stands for structural reasons and COEIN for functional causes, was employed in this single-center prospective observational study to evaluate the relative contributions of several etiological factors in AUB. To comprehend the etiological, dermographic, and therapeutic factors affecting menorrhagia in patients going through adolescence. Methods: Enrollment for females with AUB between 10 and 19 occurred between January and December 2022. A thorough history, physical examination, and laboratory evaluation, which in every case comprised standard testing, hormone analysis, and abdominal and pelvic ultrasonography were used to determine the cause of AUB. MRIs and CT scans were performed when needed. Results: There were 190 patients enrolled in total. Functional factors comprised the predominant aetiology of AUB among adolescent females: Adenomyosis=01 (0.52%), Polyp=1 (0.52%). Coagulopathy=2 (1.05%), Leomyoma=01 (0.52%), Malignancy=1 (0.52%), and PALM=4 (2.11%). COEIN=186 (97.89%), ovulation disorder=175 (92.15%), endometrial=01 (0.52%), iatrogenic=6 (3.15%), non-specified=2 (1.05%), and iatrogenic=6 (3.15%). Conclusion: The most frequent cause of AUB in the adolescent population is ovulatory abnormalities. Even though they are extremely rare, structural factors must be ruled out. A helpful technique for evaluating patients with AUB systematically is the PALM-COEIN classification.
Key-words: PALM-COEIN, Leiomyoma, AUB, Polycystic ovarian syndrome, Hormonal therapy
Derived from the bacterium Proteus vulgaris , chondroitin ABC lyase is an enzyme that can be used in treating proteoglycans that
affect neural activity (communication, plasticity). Chondroitinase can be used for vision abnormalities and spinal injuries. The
biological activity of chondroitinase is due to its ability to act on chondroitin sulfate proteoglycans (CSPGs) which are required for
normal functioning. Th is study aim s to examine various types and routes of administration of Chondr oitina se e n zymes. There is an
increasing application of chondro itin sulfate proteoglycans in spinal cord injury, vit reous attachment, and the management of
various carcinogenic conditions. Research must be done to create an effective chondroitinase delivery mech anism so that the
pharmacological activity seen in vitro and in preclinical research may be applied in the clinic. More studies are required to widen
the application of chondroitinase in therapeutics. In this review, chondroitinase ABC, B, and C are all di scuss ed. T he routes of
administration like caudal or ros tral, intracerebroventricular, hydrogels, and intrath ecal have been detailed. The current review
article highlights the different medical uses for chondroitinase, drug delivery methods for the enzym e, and chondroitinase
dispersion across bacteria. In conclusion, this study can reduce the chance of edema by the intracerebroventric ular route.
However, it is not effective for people due to the gyrencephalic anatomy of brain
Key-words: Chondroitinase, Chondroitin, Chondroitin Sulfate Proteoglycans, Spinal Injuries, Ocular Abnormalities, Proteoglycans
Background: Maturing is a widespread peculiarity. Advanced age is not in itself a sickness however is an ordinary piece of human existence length. A guardian, like wise called a career, home wellbeing assistant or individual consideration assistant, is the individual answerable for furnishing their clients with day-to-day private consideration and help with exercises. Methods: Exploration approach: unmistakable methodology research plan: graphic study research plan. The setting of the review: provincial areas of Bagalkot region. Information assortment strategy: organized polls test. The example was chosen by an arbitrary inspecting procedure. The analyst arbitrarily chose Shirur town as a provincial setting and was chosen for enrolment of subjects. Results: The information score of guardians was 41.06%, with mean and SD of 12.32±3.925. These discoveries uncover those guardians had normal information for advanced-age medical conditions. The mentality score of guardians was 73.73%, with a mean and SD of 110.6±11.008. These discoveries uncovers that parental figures have concur capable demeanour in regards to the advanced age medical conditions. Conclusion: At last, a critical co-connection between the information and demeanour at 0.001 the discoveries uncovers that there is a moderate positive relationship between the information and disposition of the advanced age medical issues.
Key-words: Assess, Care Giver, Health Problems, Knowledge, Old Age
Background: Adolescent is one of the most rapid phases of human development. Anemia is a deficiency in the number of RBC in your body. RBC carry oxygen around your body using a particular protein called hemoglobin. Normal hemoglobin level in adolescent girls 13-15 g/dl. According to WHO, the hemoglobin level 10- 11.9 g/dl is considered mild anemia, 7-9 g/dl is considered moderate, and less than 7 g/dl is called severe anemia. Methods: The present study is pre-experimental among 60 adolescent girls, using a disproportional stratified random technique. One experimental group of clients was selected without randomization and no control group was used. The data was collected by using the structured close-ended knowledge questionnaire. The data was analyzed using descriptive and inferential statistics regarding mean, frequency distribution, percentage, paired table t-test and chi-square test. Results: The overall findings reveal that the post-test knowledge mean score 26.24% with SD±5.94, which was 72% of the total score was more when compared to the pre-test knowledge mean score 12.98 with SD 5.94, which was 36.83% of total score. The calculated t-value of 24.91 was much higher than the table t-value 1.96 for the hypothesis. Conclusion: The study provides that VATP on knowledge regarding the preparation and use of moringa juice in managing anemia among adolescent girls was the scientific, logical and cost-effective strategy.
Key-words: Adolescent girls, Knowledge, VATP, Effectiveness, Socio-demographic variables.
Background: The research demonstrates that water birth comports and loosens mothers actually and intellectually. The buoyance lessens body weight and permits free development and situating to the mother. Buoyance and warm water upgrade uterine withdrawal and better blood flow, which builds uterine muscles' oxygenation, diminishes the mother's torment and increases maternal oxygenation of the child. Submersion of water assists with decreasing circulatory strain and additionally gives security, which hinders uneasiness or dread. Methods: The current review pre-trial study with 50, 4th-year B.Sc. Nursing is chosen through basic arbitrary methods. One gathering pre-test without control bunch configuration was utilized. Information was gathered through a self-directed, organized, shut, finished information survey. Data was examined by involving distinct and inferential measurements concerning mean rate by conveyance, matched "t" test, and Chi-square test for affiliation. Results: The pre-test reveals that out of 50 BSc 4th-year nursing students, the highest pre-test (62%) of BSc 4th-year nursing students had poor knowledge. Overall, the post-test knowledge score (22.6±4.19), 70.62% of the total score, was more than the pre-test knowledge score (8.76±3.95), 23.3%. The effectiveness of the assisted teaching programme, in this area, the mean knowledge score was 13.84 with SD±0.24, which was 43.25% of the total score. Hence, it indicates that the video-assisted teaching program effectively enhanced the knowledge of BSc 4th-year nursing students. Conclusion: This study concluded that video-assisted teaching programmes on knowledge regarding waterbirth among B.Sc 4th year Nursing students was the scientific, logical and cost-effective strategy.
Key-words: Effectiveness, Fourth year B.Sc. Nursing students, Knowledge, VATP, Water birth
Background: Post-menopausal women experience many physical, emotional, and mental symptoms during the post-menopausal period, and reflexology has grown into a complex therapeutic modality and has a range of effects. Reflexology will help put hormones back into a normal state and act like a process of emotional cleansing, relieving stress and restoring harmony to the body and soul. Hence, foot reflexology seems to be effective in treating post-menopausal symptoms. Methods: In the present study, pre-experimental i.e. one group pretest-posttest design, was adopted. The study was conducted on 30 post-menopausal women to assess their knowledge regarding foot reflexology. Samples were selected by using a convenient sampling technique. Data was collected using a structured knowledge questionnaire and analyzed using descriptive and inferential statistics. Results: The mean percentage of the pre-test score was 28%, and the post-test score was 76.65%. The mean and the standard deviation of the pre-test score were 5.60±1.71, and the mean and the standard deviation of the post-test score were 15.33±1.15. The total mean and standard deviation are 9.73±2.07 by comparing the pre-test and post-test scores. Hence, it was found that there is a significant difference between pre-test and post-test knowledge scores of post-menopausal women regarding foot reflexology. No significant association was found between post-test knowledge scores and socio-demographic variables on foot reflexology. Conclusion: The study concluded that a planned teaching program on knowledge regarding foot reflexology for post-menopausal women was a scientific, logical, and cost-effective strategy to reduce post-menopausal symptoms.
Key-words: Effectiveness, Foot reflexology, Post-menopausal women, Planned teaching program, Socio-demographic variables
Background: A 51-year-old woman had left lower abdomen pain for 18 hours with nausea and vomiting. Prior CT scans suggested pelvic neoplasms. Our hospital's emergency CT showed an enlarged uterus with cystic shadows, right adnexal cysts, and stomach fluid. Physical examination revealed left lower abdomen discomfort. A gynaecological examination revealed a painful, firm pelvic mass of 151210 cm. Further diagnosis is underway. Method: The patient underwent emergency exploratory laparotomy, discovering a twisted, swollen left ovary with a 540° rotation, classified as a benign cyst. It was found that the patient had congenital upper vaginal atresia and bilateral initial uteri. Pain was reduced after surgery, thanks to symptomatic treatment. An abnormal karyotype of 46, XX,1qh+ was found during genetic testing. Result: Fallopian tubes, uterus, and vagina develop from the embryonic accessory mesonephric duct. MRKH syndrome is caused by bilateral accessory mesonephric duct dysplasia and disappearance of the uterus or vagina. MRKH has three types, with Type 1 lacking uterus or vagina. Due to ovarian cyst torsion, this Type 1 MRKH with double initial uterus and upper vaginal atresia needed left adnexa resection. Genetic testing showed a typical female karyotype. MRKH's complex aetiology incorporates chromosomal abnormalities, emphasizing early cytogenetic evaluation for personalized treatment and fertility assistance. Conclusion: Early cytogenetic testing for MRKH syndrome patients is crucial for determining the underlying cause and guiding personalized treatment plans to restore reproductive function and improve quality of life.
Key-words: Double primordial uterus; MRKH syndrome; Upper vaginal atresia; Torsion of left ovarian cyst pedicle
Background: Cell phones have advanced to the degree of becoming a necessary piece of individuals' lives. Cell phones are utilised for correspondence, diversion, efficiency, interpersonal interaction, and gaming. In addition to supplanting the conventional cells, cell phones have likewise supplanted personal computers and numerous other comparative gadgets. Individuals these days feel indistinguishable from their cell phones. In lined with the rising improvement of innovation and excessive utilisation of cell phones, one of the significant issues that scientists have noticed and are chipping away at is cell phone addiction. Methods: It was a graphic study directed among 100 nursing students aged 19-22 in B.V.V.S. Institute of Nursing Sciences Bagalkot. Information was gathered utilising a structured knowledge questionnaire to survey socio-demographic information. The Stanford Sleepiness Scale (Alertness Test) was utilised to evaluate the classroom alertness of the nursing students and the Cell phone Addiction Scale-Short Version (SAS-SV) was utilised to assess the cell addiction of the nursing students. Results: An association was found between the year of studying and the classroom alertness of students (χ2 =3.9102) p<0.05. There was a significant negative correlation between cell phone addiction and classroom alertness of the nursing students, p<0.05. The r-value obtained was 0.80. Thus, the correlation between the two factors is seen as statistically significant. Conclusion In the wake of acquiring the consequences of the current work the scientist s saw a negati ve relationship between cell
pho ne addiction and the class room alertness of the students.
Key-words: Addiction, Alertness, Cell phone, Classroom, Phone addiction
Background: Chemical changes occur in the epididymis when the testicular sperm grows. When sperm and seminal fluids mix during ejaculation, a substance called semen is formed. The cervical mucus of a fertilized egg screens out the best possible sperm. For infertility, Intra Cytoplasmic Sperm Injection (ICSI) can be necessary. Test sperm that are DNA efficient, normal, and motile using Swim Up. Sperm could be damaged by reactive oxygen species that are produced during centrifugation. All infertility treatments should take these factors into account. Methods: The in vitro fertilization (ICSI) procedure was administered to fifty male patients who were 35 years old or younger and tested positive for normozoospermia, asthenozoospermia, and oligozoospermia. After obtaining informed consent, a Swim-Up was performed using both the full semen and a washed pellet. With sperm obtained from both methods, six Metaphase-2 stages of oocytes (MII oocytes) were implanted in each patient. A Tri-gas Bench-top incubator was used to put each injected oocyte in its 37°C setting. Results: The study showed that the age differences were insignificant (p=0.722), but significant variations emerged in sperm concentration before processing (p=1.030) and after (p=1.064). Sperm morphology differences were evident before processing (p=0.004) and after (p=0.002). No significant differences were noted in the number of Day 3 cleavage stage embryos. Conclusion: The study concluded that there is no significant difference between the two techniques regarding sperm washing efficiency.
Key-words: Sperm preparation methods, Swim-up, Centrifugation, ICSI, Fertilization, Day 3 Embryo
Background: The third most common musculoskeletal symptom in orthopaedic clinical practice is a sore shoulder, which can cause significant morbidity. It has been reported that 7–27% of the general population has it, and 36–66% of overhead arm athletes have it. Pathophysiology includes functional, degenerative, and mechanical factors. Most shoulder pain is subacromial pain syndrome (SAPS), often known as ‘shoulder impingement syndrome’. Impingement hypothesis: shoulder joint structures mechanically clash. SAPS accounts for 36–48% of shoulder discomfort. Methods: This observational study was conducted in the Department of Orthopaedics, MKCG Medical College and Hospital, Berhampur, among Eastern Indian outpatients. The study included adult patients (ages 18–75) of both sexes who presented to MKCG Medical College and Hospital's OPD with shoulder pain from December 2020 to November 2022 and were diagnosed with Shoulder Impingement Syndrome (SIS). Thorough histories and clinical exams were done. The Department of Radiology, MKCG Medical College and Hospital, Berhampur, performed conventional shoulder MRIs on the selected participants. Results: Most cases and controls were Type-II (43.3%), followed by Type-I (28.3% and 30%, 29.2% of the total group). The study's least common acromial shape was type-IV, seen in 5% of cases and 10% of controls (7.5% of the sample). Fisher's exact test showed no significant connection between subacromial impingement and acromial shape (p=0.65). With a p-value of 0.045, cases had a significantly greater acromial width (8.12±2.16 mm) than controls (7.51±0.81 mm). Conclusion: Sub-acromial impingement was unrelated to acromion morphology. There was no correlation between acromial morphology and rotator cuff injuries.
Key-words: Shoulder Impingement Syndrome, Acromion Morphology, MRI
Impact of Acceptance and Mindfulness-Based Intervention as an Add-on Treatment for Skin Diseases-Acne, Eczema and Psoriasis
http://dx.doi.org/10.21276/SSR-IIJLS.2020.6.5.2
Seasonal Incidence and Varietal Response of Gram against Helicoverpa armigera (Hubner) at Talwandi Sabo, Punjab
http://dx.doi.org/10.21276/SSR-IIJLS.2020.6.4.3
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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ASA GUIDELINE
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae