This document provides an introduction to genetics concepts including:
1) Genes located on chromosomes are segments of DNA that code for proteins which determine traits. Traits are physical characteristics influenced by alleles which are different versions of genes.
2) Genotype refers to the alleles an organism receives from its parents, while phenotype describes the physical traits that are expressed.
3) Dominant alleles will always be expressed over recessive alleles in determining an organism's phenotype, with the exception of traits only expressed in the homozygous recessive genotype.
This Power Point Presentation is designed to explain Mendel's experiment on hybridization and dihybrid cross which considers inheritance of two traits at a time and to know whether they are inherited independently or are influenced by each other and also about Law of Independent assortment
Examples of Codominance. The best example, in this case, is the codominance blood type. ABO group is considered to be a codominant blood group where both father’s and mother’s blood group is expressed. It means that the properties of the blood groups exist in the ABO type.
Codominance is a relationship between two versions of a gene. Individuals receive one version of a gene, called an allele, from each parent. If the alleles are different, the dominant allele usually will be expressed, while the effect of the other allele, called recessive, is masked.
This Power Point Presentation is designed to explain Mendel's experiment on hybridization and dihybrid cross which considers inheritance of two traits at a time and to know whether they are inherited independently or are influenced by each other and also about Law of Independent assortment
Examples of Codominance. The best example, in this case, is the codominance blood type. ABO group is considered to be a codominant blood group where both father’s and mother’s blood group is expressed. It means that the properties of the blood groups exist in the ABO type.
Codominance is a relationship between two versions of a gene. Individuals receive one version of a gene, called an allele, from each parent. If the alleles are different, the dominant allele usually will be expressed, while the effect of the other allele, called recessive, is masked.
Law of Dominance - Recessive alleles will always be masked by dominant alleles .
Law of Segregation - At the time of gametes formation the two copies of each hereditary factor segregates so that offspring get one factor from each parent .
Law of Independent Assortment - Genes for one trait are not inherited together with another trait .
its deals with the general basic ideas of gene and evolutions.different types of examples are used to explain the gene and evolutions.the origin of basic genetics and their ideas are also formulated in this presentation
Law of Dominance - Recessive alleles will always be masked by dominant alleles .
Law of Segregation - At the time of gametes formation the two copies of each hereditary factor segregates so that offspring get one factor from each parent .
Law of Independent Assortment - Genes for one trait are not inherited together with another trait .
its deals with the general basic ideas of gene and evolutions.different types of examples are used to explain the gene and evolutions.the origin of basic genetics and their ideas are also formulated in this presentation
A systematic approach to Genotype-Phenotype correlationsfisherp
It is increasingly common to combine Microarray and Quantitative Trait Loci data to aid the search for candidate genes responsible for phenotypic variation. Workflows provide a means of systematically processing these large datasets and also represent a framework for the re-use and the explicit declaration of experimental methods. Here we highlight the issues facing the manual analysis of microarray and QTL data for the discovery of candidate genes underlying complex phenotypes. We show how automated approaches provide a systematic means to investigate genotype-phenotype correlations. This methodology was applied to a use case of resistance to African trypanosomiasis in the mouse. Pathways represented in the results identified Daxx as one of the candidate genes within the Tir1 QTL region.
Phenotype terminologies in use for genotype-phenotype databases: a common cor...Human Variome Project
The community needs to be provided with terminology standards in order to achieve interoperability between databases intended for clinical research and including description of phenotypes. This is crucial to interpret genomic rearrangements as well as future high-throughput sequence data. The aim of our work was to promote a core terminology of phenotypes interoperable with all the terminologies in use. Relevant terminologies in use by different communities to describe phenomes were cross–referenced: PhenoDB (2846 terms), London Dysmorphology Database (LDDB; 1318 terms), Orphanet (1243 terms), Human Phenotype Ontology (9895 terms, 22/08/2012), Elements of Morphology (AJMG; 423 terms), ICD10 (1230 terms), as well as medical terminologies in use: UMLS (7,957,179 distinct concept terms), SNOMED CT (>311,000 concepts), MeSH (26,853 concepts) and MedDRA (69,389 concepts). We established a strategy to compare them to find commonalities and differences, using ONAGUI as a tool to pick-up exact matches. The non-exact matches were verified manually by an expert. A core-terminology of 2,300 terms was derived and analysed by a panel of experts (International Consortium for Human Phenotype Terminologies – ICHPT). The resulting consensual terminology will be freely available in a dedicated website (www.ichpt.org) and mappings with other terminologies will be given in order to ease the interoperability between databases without disturbing the habits of the different groups of users.
This presentation is one of the series as part of the Australian Curriculum for Year 10 Science students. It covers the Biological Sciences (BS) strand of Science Understanding.
10 BS Genetics I AO covers the theme of 'Transmission of heritable characteristics from one generation to the next involves DNA and genes (ACSSU184)'.
The elaboration is describing the role of DNA as the blueprint for controlling the characteristics of organisms.
Considerations about dissemination of improved fish strains for aquacultureWorldFish
One of the largest aquaculture and aquarium shows in Asia, Aqua Aquaria India 2013, was recently held in Vijayawada, AndhraPradesh, India, from 8 – 10 February.
Hosted by the Marine Products Export Development Authority of the Government of India (MPEDA), the event showcased the latest production and marketing technologies in aquaculture and ornamental fish culture to hatchery operators and breeders, technical staff, and more than 5000 local fish and shrimp farmers.
National and international experts on aquaculture and ornamental fish presented technical sessions sharing their experience and research findings.
Aquaculture and Genetic Improvement scientist, Dr. Curtis Lind, made a presentation based on a WorldFish publication entitled ‘Considerations about the dissemination of improved fish strains’ authored by R.W. Ponzoni, H.L. Khaw, N.H. Nguyen and B.M. Rodriguez Jr. (Download publication here: http://www.worldfishcenter.org/resources/publications/considerations-about-dissemination-improved-fish-strains).
The publication summarizes key strategies, knowledge and experience related to the multiplication and dissemination of improved fish strains, and makes recommendations on how some of the practices may be improved.
If implemented, these improved practices may help fish farmers increase the productivity and profitability of their farms.
Related project:
Unleashing the potential of GIFT tilapia on the Indian subcontinent led by the WorldFish Genetics Team in partnership with the Rajiv Gandhi Center for Aquaculture (RGCA). (See more information on the project here http://www.worldfishcenter.org/ongoing-projects/unleashing-potential-gift-tilapia-indian-subcontinent).
Genes, Chromosomes, and Genetic Code: Relevance and ImplicationsJen Gragera
Genes are the thing that determines your unique traits from the inside out. They play an important role in your overall health but they can also make you more susceptible for certain health problems and diseases, in the first place those that run in your family. Most diseases are a result of a combination of multiple factors including dietary, lifestyle and environmental factors. However, it is also possible to develop health problems exclusively due to genetic abnormalities and mutations.
2. I CAN…
• I CAN explain the relationship
between
chromosomes, DNA, genes, alleles, pr
oteins, and traits
• I CAN explain the difference between
genotype and phenotype
• I CAN differentiate between
homozygous and heterozygous
• I CAN determine phenotype based on
dominant and recessive alleles.
3. WHAT CONTROLS WHAT I LOOK LIKE?
ANSWER: GENES!
Genes – sections of DNA that
code for proteins. Proteins
determine your traits. B=brown b=blue
Traits – physical
characteristics
(color, height, size, personalit
y etc.)
Alleles – different types of
genes
Ex: alleles for eyes could be
brown, blue, green, hazel, etc.
4. CFU
What might be two different allele types of hair color?
What macromolecule plays an important role in determining
your traits?
Arrange from smallest to biggest:
DNA, gene, chromosome, nucleotide
5. WHERE DO MY GENES COME FROM?
Review: you get one set of 23 chromosomes from your
mom and another set of 23 chromosomes from your dad
– sexual reproduction
• You can get different types of genes from your
mom and dad different alleles
• Ex: Allele for blue eyes from dad, brown eyes
from mom
6. WHAT IS A WHAT IS A
GENOTYPE? PHENOTYPE?
• genotype - letter showing each • Phenotype –physical
allele we get from our parents characteristic
• Ex: brown eyes from dad • Ex: brown
(B) + blue eyes from mom eyes, curly
(b) = Bb hair, widow’s
• If the alleles are the same (BB peak, sickle cell
or bb) the organism is disease, etc.
homozygous for the trait • Different alleles
code for different
• If the alleles are different (Bb) phenotypes!
the organism is heterozygous
for the trait
7. CHECK FOR
UNDERSTANDING
For the following examples, write down if the person is
homozygous or heterozygous for a specific trait
EE
Ee
ee
8. SO HOW DO YOU DECIDE
WHICH TRAIT TO SHOW?
There is a battle going on…
between your Mom and Dad’s alleles!
9. DOMINANT VS. RECESSIVE
• dominant allele always wins over the
recessive allele. It’s the phenotype that
shows up.
• It’s always the capital letter
• recessive allele is the loser. It’s always
overshadowed if a dominant allele is
present
• Phenotype is only expressed if the
organism’s genotype is homozygous
recessive ex: bb, hh, tt, etc.
• Always the lowercase letter CU Buffs
DOMINATING, as per
usual.
“DOMINANT TRAIT...I'll overpower you!
RECESSIVE TRAIT...I will hide!”
10. CHECK FOR UNDERSTANDING
B is the allele for brown hair and b is the allele for
blonde hair. What will be the phenotype of a
reebop with the genotype Bb?
Is the person homozygous or heterozygous for
this trait?
STEP UP: Widow’s peak (w) is a dominant trait. If
a dad is homozygous for widow’s peak and the
mom has no widow’s peak, what are the parents
genotypes?
Will their kid have a widow’s peak?
Widow’s peak
11. PRACTICE MAKES PERFECT!
homozygous or heterozygous?
TT = _________________
tt = __________________
Tt = __________________
dominant or recessive trait expressed?
TT = _________________
tt = __________________
Tt = __________________