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11. Intra-embryonic Mesoderm
• It is formed from proliferating cells from sides
of primitive node and streak.
• It fills the space between ectoderm and
endoderm except at buccopharyngeal
membrane, cloacal membrane (fusion
between ectoderm and endoderm caudal to
primitive streak) and median region which is
occupied by notochord.
Dr. Sherif Fahmy
15. Differentiation of Intra-embryonic
Mesoderm
• Intra-embryonic mesoderm on each side
of notochord, divides into:
1- Paraxial Mesoderm: on both sides of
notochord.
2- Intermediate Mesoderm: Middle part of
the mesoderm.
3- Lateral plate Mesoderm: Lateral part
which communicates with that of the
opposite side infront prochordal plate.
Dr. Sherif Fahmy
20. 1-Paraxial Mesoderm
• It is the most medial mesoderm.
• It is divided into cubical masses called somites
(42 – 44 pairs).
• Formation of somites starts At the 20th day
by formation of one pair at cranial region.
Then this followed by formation of 3 pairs/day
till day 30 then the rate becomes slower to
complete full number at the end 5th week.
• Somites are classified into: 4 occipital, 8
cervical, 12 thoracic, 5 lumbar, 5 sacral and 8 –
10 coccygeal. Dr. Sherif Fahmy
24. Fate (Organisation) of Somites
• 1- Sclerotome: It is ventro-medial part
that form vertebral column and
intervertebral discs.
• 2- Dermo-myotome: It is the dorso-
lateral part which subdivided into:
A- Dermatome: Forms dermis of skin.
B- Myotome: Forms skeletal muscles of
trunk and limbs.
Dr. Sherif Fahmy
27. 2-Intermediate Mesoderm
• Narrow strip between paraxial
and lateral plate mesoderm.
• It is divided into many
segments.
• It forms uro-genital system.
Dr. Sherif Fahmy
28. Lateral Plate Mesoderm
• Flat plate of mesoderm between intermediate
mesoderm and margin of embryonic disc.
• It is continuous with that of other side infront
prochordal plate.
• Intra-embryonic coelom: It is formed from fused
small cavities. This coelom forms serous
membranes of the body (pericardium, pleura and
peritoneum).
• Lateral plate mesoderm is split by the coelom into:
-Somatic mesoderm & Splanchnic mesoderm.
Dr. Sherif Fahmy
