The document summarizes the procedure for infertility treatment using intrauterine insemination (IUI). It involves stimulating a woman's ovaries to produce multiple eggs, preparing sperm by separating normal from abnormal sperm, and placing the sperm directly into the uterus. Success rates are 10-20% per cycle and depend on factors like the woman's age. Potential risks are rare infections, but careful technique can prevent issues. The procedure takes 15-20 minutes and patients can resume normal activities after.

2. Procedure to treat infertility by:
 Ovaries Stimulated to produce more eggs
 Seminal fluid washed in artificial media and
introduced into the uterus
 Sperms swims towards the egg for fertilization
to take place
 Entire procedure takes 15-20 minutes

3. Can be either due to abnormal sperm
shape, motility and viability. IUI helps to
separate the normal sperms from abnormal
sperms thus achieving fertilization.
Abnormal position of the cervix preventing
sperm travel to the egg.
Thick cervical secretion during ovulation thus
preventing sperm ascent to the uterus and to
the egg.

4. Some woman are allergic to the protein in the
semen of their husband which causes discomfort
after intercourse so most couple prevent intercourse
thus preventing pregnancy.
There are many unexplained reasons for infertility
for which the only treatment solution is IUI.

6. Monitoring
Ovulation
• Monitoring of ovulation is done by vaginal
ultrasound after the woman is given
ovarian stimulating drugs to make sure of
the maturity of the follicles
• Doctor usually prefers having at least 1-3
mature follicles to give the HCG injection
Preparation
of the
semen
sample
• After 2-5 days of abstinence semen
collected in hospital
• Normal sperm isolated from abnormal
sperms
• Sperm separated form other components
and concentrated in a media.
• Total time for sperm preparation 30-60
minutes.

7. Done in the
clinic of the
doctor, and
there is no
need for
medication
or an
analgesic
during the
procedure
Speculum is
placed in
the vagina
and
cervical
area is
cleaned
Specimen of
highly motile
sperm is
placed in
the uterine
cavity using
a special
flexible
catheter

8. Success rate of Intra Uterine
Insemination - IUI:
 The pregnancy rate of IUI is 10-20% and it
depends on the age of the wife, her health
situation, and also on the number of motile
sperm that is used in each cycle, and the
pregnancy rate in 2 IUI cycles using 5 million
sperm is more than the pregnancy rate in 1 IUI
cycle using 10 million sperm.

9. 10% chance per month using
clomid, and IUI for up to 3 cycles
15-20% chance per month using
injection by FSH medication, and
IUI for up to 3 cycles.

10.  Rarely, IUI may cause infection in
the uterus and tubes, from
bacterial contamination that
originate either from semen
sample, or contamination of
sterile catheter in the vaginal or
cervical area during the
procedure. Careful cleaning of
the cervix and cautious
technique alleviate this and
make it a rarity.

11. The IUI is usually done twice during the
treatment cycle, and it has been proved that
doing the IUI twice increases the pregnancy
rate because it decreases the loss of the
fertility period during the ovulation, but there
was a study that was done comparing the
pregnancy rate after IUI on one time, or two
times, and found no difference.

12. Usually, the IUI procedure takes from 15-20
minutes. The patient is then asked to lie
down on her back for a period of time
The patient can continue her
normal life, and passage of a small
amount of blood in 1-2 days after
IUI is normal

13. Pregnancy test should not be done before 2
weeks have past since the IUI. Doing it before
this may cause false negative result (which
means that the patient is pregnant while the
test is negative), and in the cases where
hormones are used for ovulation induction, like
HCG, doing the pregnancy test before 2
weeks can cause a false positive result (which
means that the patient is not pregnant while
the test is positive that is caused by the HCG
hormone that is found in the blood).

14.  It can be repeated 3-6 times to increase
the pregnancy rate
 It can be repeated after at least one
month or more, this depends on the
doctor's and the couple's mutual
decision
If IUI fails after 4 trials, it is
preferred not to repeat it. The
doctor will decide the next
step according to the case

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