Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
The so Called Brugada Syndrome The True HistoryBortolo Martini
The syndrome of sudden Death, right bundle branch block and ST elevation was firstly described by A.Nava and B. Martini in 1988-1989, and only five years later by the Brugada Brothers. The ECG pattern is due to a conduction disturbance of the RVOT, caused by fibrofatty substitution of that structure.
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
The so Called Brugada Syndrome The True HistoryBortolo Martini
The syndrome of sudden Death, right bundle branch block and ST elevation was firstly described by A.Nava and B. Martini in 1988-1989, and only five years later by the Brugada Brothers. The ECG pattern is due to a conduction disturbance of the RVOT, caused by fibrofatty substitution of that structure.
Its crucial to diagnose arrythmias quickly and treat it promptly.
Here i have made small attempt to diagnose tachyarrythmias briefly and proceeds with its immediate managenent..
This presentation describes the epidemiology, initial assessment, investigation and emergency department management of a patient with atrial fibrillation. Some new research evidences are also discussed to answer some dilemmas.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
4. .
Partial IAB (P-IAB) : P wave duration that equals or exceeds 120
milliseconds and a bimodal morphology, especially in leads I, II, VL
or inferior leads.
6. .
The prolonged P wave duration (P-wave duration ≥120
milliseconds) may be present in the elderly but can also be a
consequence of acute illness, such as pericarditis or acute
myocardial infarction.
7. .
The combination of LAE with advanced interatrial block (A-IAB) is
very common but isolated cases of A-IAB may be seen.
8. .
Cutting the Bachmann’s bundle at either the right or left atrial side
results in a typical ECG pattern with wide P wave with biphasic
morphology in inferior leads.
9. .
The interatrial blocks may be of first (partial), second (transient
interatrial block is part of atrial aberrancy), or third degree
(advanced).
10. .First-degree (Partial) Interatrial Block
-The electrical impulse is conducted from the right to the LA
through the normal propagation route but with a delay.
-The ECG shows that a P wave of 120 milliseconds or more, usually
bimodal, is especially visible in leads I, II, or III.
11. Second-degree Interatrial Block
Interatrial block occurs transiently on a beatby- beat basis or may
be recorded momentarily.
The morphology of the P wave may change in the same recording
from interatrial block pattern (first or third degree) to normal
pattern, usually transiently in relation to the preceding premature
beats.
These changes may be considered as atrial aberrancy.
Atrial aberrancy may also present a transient bizarre P wave
without the morphology of interatrial block. In these cases, the
location of the block is usually the right atrium.
12. Third-degree (advanced) Interatrial Block
The electrical impulse is blocked especially in the upper and middle
part of the interatrial septum, in the Bachmann’s bundle zone,
and/or in the upper part of LA.
Retrograde left atrial activation occurs mainly via muscular
connections in the vicinity of coronary sinus.
In rare occasions, the right atrium and LA can demonstrate
dissociated electrical activity.
13. Third-degree (advanced) Interatrial Block
The ECG shows that
(a) P wave duration of 120 milliseconds or more.
(b) the morphology of P wave is usually biphasic [±] in leads II, III,
and VF ( and also often in V1 to V3)
The electrophysiological mechanism underlying this ECG pattern has been explained using deductive ECG-VCG data.
14. Third-degree (advanced) Interatrial Block
In dogs, the same biphasic morphology appears after cutting the
Bachmann’s bundle at the right and left sides of the septum.
Atrial fibrosis is considered the anatomic substrate of A-IAB, which
does not necessarily mean that the LA is enlarged.
P wave (biphasic in inferior leads) that pinpoints that there is a
retrograde activation of the LA.
This type of block is very frequently accompanied by paroxysmal
atrial arrhythmia.
16. Inter-Atrial Block degrees
1st
d: pIAB: prolonged P-wave duration>120 ms.
2nd
d: tIAB: transient IAB, ( a, p)
3rd d: aIAB : prolonged P-wave duration>120ms + biphasic P-wave
morphology.
- Bayés syndrome: The association of A-IAB and AF.
17. .
The prevalence of partial (P) and advanced A–IAB is rare before
the age of 50.
The prevalence is much higher with advancing age.
In patients with heart failure a prevalence of A-IAB of 10 %.
18. .
The advanced IAB group presented a higher incidence of atrial
flutter/fibrillation during a 30-month follow-up compared with
partial IAB.
At one year of follow-up, the incidence of arrhythmias was 80 %
and 20 % of AIAB and PIAB respectively.
The prevalence of frequent premature atrial contractions (more
than 60/h by Holter) was much more frequent in advanced (75 %)
than in partial (25 %) IAB.
20. .
The strong relationship between advanced IAB and atrial flutter/
fibrillation suggests the possible role of preventing atrial
arrhythmias using antiarrhythmic drugs.
A small comparative trial of patients with advanced IAB received
either an antiarrhythmic drug or a placebo.
A significant reduction of AF recurrences was observed at follow-up
in the group receiving prophylactic antiarrhythmic medication.
21. BAYÉS SYNDROME
Bayés syndrome is a new
clinical entity, characterized
by the association of
advanced interatrial block
(IAB) on surface
23. BAYÉS SYNDROME
In 1988, Bayés de Luna et al.1 reported that patients with advanced interatrial
block (IAB) presented with supraventricular arrhythmia more often than
patients with partial IAB. However, until a consensus article was published
on IAB in 2012,2 only a few authors had shown interest in the subject,
mainly the groups led by Spodick,3 García-Cosío,4 and Platonov,5 as well
as our own group.6,7 Since this consensus article was published, there has
been growing interest, and Conde and Baranchuk8 named this
combination “Bayés syndrome,” a term quickly accepted by the scientific
community.
24. THANKS
The reference: Antoni Bayés de Luna,Albert Massó-van Roessel,Luis Alberto Escobar Robledo;
The Diagnosis and Clinical Implications of Interatrial Block.European Cardiology Review
2015;10(1):54–9