The document discusses various types of insulin and insulin delivery methods for managing diabetes. It describes a 37-year-old man with type 1 diabetes of 18 years whose HbA1c is consistently high at 9.0-10.5% despite different insulin regimens. It then discusses options like Glargine insulin and education programs that can help improve blood sugar control and reduce hypoglycemia for patients.
Vanita R. Aroda, MD, prepared type 2 diabetes mellitus infographics for this CME activity titled, "Putting Basal Insulin Therapy to Work for Patients With Type 2 Diabetes Mellitus." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2kdVkuJ. CME credit will be available until September 12, 2020.
Vanita R. Aroda, MD, prepared type 2 diabetes mellitus infographics for this CME activity titled, "Putting Basal Insulin Therapy to Work for Patients With Type 2 Diabetes Mellitus." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2kdVkuJ. CME credit will be available until September 12, 2020.
Many have troubles choosing the proper insulin type and dosing for their patients.. Here is a quick presentation that introduce you to different studies in that matter.
This presentation is intended for healthcare prfessionals
Many have troubles choosing the proper insulin type and dosing for their patients.. Here is a quick presentation that introduce you to different studies in that matter.
This presentation is intended for healthcare prfessionals
This presentation was delivered at the 2017 JDRF TypeOneNation Summit in Tulsa, OK on 1/28/2017. It is a summary of insulin pumps, CGMs, data display and management software, and other aspects of technology related to type 1 diabetes.
A Mathematical Model for the Enhancement of Stress Induced Hypoglycaemia by A...IJRES Journal
The normal distribution is a very commonly occurring continuous probability distribution. In this paper the Multivariate Normal distribution is used for finding the mgf of the curve for the enhancement of stress induced Hypoglycaemia with consideration of the variablesProlactin, ACTH, Growth Hormone, Blood Pressure, Plasma Glucose, Plasma Renin, Epinephrine, Cortisol. These variables are treated with the drugs (citalopram and tianeptine) and the joint moment generating function for the variables in Citalopram, Tianeptineand Placebo casesare found out and are given as curves in the Mathematical Results
Newborn Care: Skills workshop Glucose control and hypoglycaemiaSaide OER Africa
Newborn Care was written for healthcare workers providing special care for newborn infants in level 2 hospitals. It covers: resuscitation at birth, assessing infant size and gestational age, routine care and feeding of both normal and high-risk infants, the prevention, diagnosis and management of hypothermia, hypoglycaemia, jaundice, respiratory distress, infection, trauma, bleeding and congenital abnormalities, communication with parents
Newborn Care was written for healthcare workers providing special care for newborn infants in level 2 hospitals. It covers: resuscitation at birth, assessing infant size and gestational age, routine care and feeding of both normal and high-risk infants, the prevention, diagnosis and management of hypothermia, hypoglycaemia, jaundice, respiratory distress, infection, trauma, bleeding and congenital abnormalities, communication with parents
An insightful presentation on issue of Hypoglycaemia in patients of Diabetes Mellitus with focus on causes, symptoms and management. Also find included experience based inputs on issue of vehicle driving and hypoglycaemia
Intensification Options after basal Insulin RevisitedUsama Ragab
Intensification Options revisited
By Dr. Usama Ragab Youssif
Add an OAD
Add a short-acting insulin at mealtime
Switch to premixed insulins
Novel insulin combinations
Basal insulin/GLP-1 RA combinations
Case studies in the managment of type 2 diabetes NasserAljuhani
Case 1:Poorly controlled type 2 diabetes on triple oral therapies
Case 2:Morning hypoglycemia on premixed InsulinCase 3
Case 3:Newly diagnosed D.M Type1D.M or type 2 D.M ?
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
16. 1530 Levemir® vs. NPH in treat-to-target trial: Hypoglycaemia Hypoglycaemia Hermansen K, et al., Diabetologia 2004;47(Supplement 1):A273
17.
18. Within-patient variability with NPH insulin Selected clamp profiles on 4 identical study days for 8 out of 17 subjects on NPH who completed the study The CV for all 17 patients on NPH who completed the study was 68% Heise, T. et al., Diabetes, 2004; Vol. 53: 1614-1620 Data on file: InsDet 09 2004
19. Within-patient variability with Levemir ® Selected clamp profiles on 4 identical study days for 8 out of 18 subjects on Levemir ® who completed the study The CV for all 18 patients on Levemir ® who completed the study was 27% Heise, T. et al., Diabetes, 2004; Vol. 53: 1614-1620 Data on file: InsDet 09 2004
20. HbA1c (%) Post- Baseline Post-CSII Post-TIFA Changes in HbA1c during transfer to Pump therapy (CSII) Individual patients
25. Randomisation N Engl J Med 2007; 357: 1716-30 * Intensify to a combination insulin regimen in year one if unacceptable hyperglycaemia 708 T2DM on dual OAD Add biphasic insulin twice a day Add prandial insulin three times a day R Year 1 Comparison of three single insulin regimens, added to OADs* Add basal insulin once (or twice) daily Add prandial insulin at midday Add basal insulin before bed Years 2 and 3 If HbA 1c >6.5%, stop sulfonylurea and add a second insulin formulation Add prandial insulin three times a day
26.
27. Primary Outcome: HbA 1c at One Year N Engl J Med 2007; 357: 1716-30 — Biphasic — Prandial — Basal Mean ±SD at 1 year (%) 7.3±0.9 Baseline to 1 year (%) -1.3±1.1 7.2±0.9, p=0.08 vs. biphasic 7.6±1.0, p<0.001 vs. biphasic or prandial -0.8±1.0 -1.4±1.0 Months since randomisation Glycated haemoglobin (%) P<0.001
28. Glucose Profiles Before & After Starting Insulin — Biphasic — Prandial — Basal Change in FPG (mmol/l)) -2.5±3.1 Change in PPG (mmol/l) -3.8±3.5 - 1.3±2.7 -3.3±2.9 -2.6 ±3.0 -4.6±3.0 p<0.001 vs. biphasic p<0.001 vs. biphasic or prandial 0 — At baseline
29. Hypoglycaemia (≥ Grade 2) at One Year N Engl J Med 2007; 357: 1716-30 Months since randomisation Proportion with events (%) P=0.001 — Biphasic — Prandial — Basal Mean at 1 year (events/patient/year) 5.7 12.0, p<0.002 vs. biphasic 2.3, p=0.01 vs. biphasic, p<0.001 vs.prandial
30.
31.
32.
33. Raskin P, Rojas P, Hu P et al. Comparison of twice-daily biphasic insulin aspart 70/30 (NovoLog Mix® 70/30) with once-daily insulin glargine in patients with type 2 DM on oral antidiabetic agents. Diabetes Care 2005; 28; 260-5.
34. 1530 Levemir® vs. NPH insulin Treat-to-target trial: Weight p<0.001 Hermansen K, et al., Diabetologia 2004;47(Supplement 1):A273
35. Baseline BMI 35 36 34 39 55 37 42 50 69 76 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 -0.5 Mean weight change (kg) 25 >25-27 >27-29 >29-31 >31 Insulin detemir NPH insulin 1530 Hermansen: Change in weight by baseline BMI K. Hermansen et al. EASD 2005
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