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KISS :KEEP INSULIN SAFE AND SIMPLE ,[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
[object Object],Adapted from White, N et al, J  Pediatr.  2001 Dec; 139(6): 804-12 .
 
 
 
DCCT/EDIC ,[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
First commercial insulin
 
BANTING-1891-1941 & BEST-1899-1978 Orthopod who became a physiologist and died in air crash in Newfoundland while on wartime mission Together they isolated insulin and Banting won the Nobel Prize in 1923 knighted in 1934
 
 
 
 
 
 
 
 
 
 
 
 
Initiating insulin in T2DM ,[object Object],[object Object],[object Object],[object Object]
STEP 1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A1C  ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Lower A1C level Reduces the Risk of Complications DCCT  *  KUMAMOTO *  UKPDS Each 1% fall in A1C results in 20-30% RRR in microvascular compln
Long-term Complications of Diabetes Mellitus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
HbA 1c  and Microvascular Complications Relative Risk 15 13 11 9 7 5 3 1 HbA 1c ,  % 7 8 9 10 11 12 Neuropathy Nephropathy Retinopathy
Every 1% HbA 1c  Increase Above Goal Elevates the Risk of Diabetic Complications Increase in Any Diabetes-Related  Endpoint Increase in Risk of Myocardial Infarction (MI) Increase in Risk of Stroke Increase in Risk of Microvascular Complications Incidence of Diabetes- Related Complications (%) +21% +37% +12% +14% Adapted from Stratton et al.  BMJ . 2000;321:405-412.
Lower A1C level Reduces the Risk of Complications DCCT  *  KUMAMOTO *  UKPDS Each 1% fall in A1C results in 20-30% RRR in microvascular compln
Good Glycemic Control (Lower HbA 1c )  Reduces Incidence of Complications DCCT Research Group.  N Engl J Med . 1993;329:977-986. Ohkubo Y et al.  Diabetes Res Clin Pract . 1995;28:103-117. UKPDS 33:  Lancet .   1998;352:837-853. HbA 1c Retinopathy Nephropathy Neuropathy Macrovascular disease DCCT 9    7% 63% 54%  60% 41%* Kumamoto 9    7% 69% 70%  – – UKPDS 8    7% 17-21% 24-33%  – 16%* * not statistically significant
 
 
 
 
 
Chris Rhodes Ph.D. PNRI, Seattle, WA. TYPE 2 DIABETES – A QUESTION OF BALANCE PERIPHERAL INSULIN RESISTANCE BETA CELL MASS AND FUNCTION NON DIABETIC STATE BETA CELL MASS AND FUNCTION PERIPHERAL INSULIN RESISTANCE DIABETIC STATE
 
 
 
 
STEP 2 Co morbidity/Life style/Co Rx. ,[object Object],[object Object],[object Object]
 
WALKING MORE BUT NOT ENOUGH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Lifestyle
The long term goal might be 30- 40 minutes or 10000 steps per day WALK MORE ,WALK EACH DAY AND WALK MORE EACH WEEK
 
Lifestyle
 
 
 
WT.GAIN IN TYPE 2 DM ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Wrong Insulin ,[object Object],[object Object],[object Object],[object Object]
METFORMIN ADVANTAGE ,[object Object],[object Object],[object Object],[object Object]
 
 
 
 
EAT LESS AND WALK MORE. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
SEC.CAUSES Conts…. ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
DIABETES PROGRESSION ,[object Object],[object Object],[object Object],[object Object]
 
INSULIN SECRETION FAILS
 
 
FIRST PHASE INSULIN SECRETION
 
BETA CELL FUNCTION
 
T2DM –NATURAL HISTORY
FAILURE OF SU AND SECRETAGOGUES. ,[object Object],[object Object],[object Object],[object Object]
 
STEP 3. WHICH BASAL INSULIN ,[object Object],[object Object],[object Object],[object Object],[object Object]
INTERMEDIATE ACTING ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
LONG ACTING INSULIN ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
Insulin Glargine : Structure Insulin Glargine : 21 A -Gly 30 B a-L-Arg-30 B b-L-Arg-insulin Metabolites : M1-21 A -Gly-insulin M2-21 A -Gly-des-30 B -Thr-insulin Substitution Extension A-chain B-chain 1 5 10 15 20 Asn 1 5 10 15 20 25 30 Arg Arg Gly
 
BASAL INSULINS  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CONS  analogue ,[object Object],[object Object],[object Object],[object Object]
 
 
 
 
New Long Acting Insulin (Glargine Insulin) ,[object Object],[object Object]
 
 
 
 
 
STEP 4.  DOSE TITRATION ,[object Object],[object Object],[object Object],[object Object]
INITIATION&TITRATION
 
 
FESTINA LENTE- HASTEN SLOWLY ,[object Object],[object Object],[object Object],[object Object]
SWITCHING FROM ISOPHANE TO ANALOGUE BASAL INSULIN ,[object Object],[object Object],[object Object],[object Object]
STEP 5.  SHOULD OAD BE STOPPED&/OR BOLUS INSULIN STARTED ,[object Object],[object Object],[object Object],[object Object]
 
 
What is the patient”s A1c?  ,[object Object],[object Object],[object Object],[object Object],[object Object]
HIDDEN HYPERGLYCAEMIA ,[object Object],[object Object],[object Object],[object Object]
MORNING HYPERGLYCAEMIA ,[object Object],[object Object],[object Object],[object Object],[object Object]
HOW TO TACKLE POST PRANDIAL HIGHs? ,[object Object],[object Object],[object Object]
Glycemic Index for Food ,[object Object],[object Object],[object Object],[object Object],[object Object],Food Glycemic Index Glucose 100 Honey 91 Brown Rice 88 Corn Flakes Cereal 83 Wheat Bread 72 Table Sugar 64 Banana 61 Sweet Corn 58 Oatmeal Cookies 57 Sweet Potato 50 Orange Juice 49 Macaroni 46 Ice Cream 38 Milk 34 Peanuts 10
 
 
 
FOODS THAT MUST BE AVOIDED ,[object Object],[object Object],[object Object],[object Object]
Sweet food
Sweet food
Fat food
Meat
FOODS TO BE CONSUMED IN LIMITED AMOUNTS ,[object Object],[object Object],[object Object]
BENEFICIAL FOODS ,[object Object],[object Object]
Cereals
Vegetables
Vegetables
Raw vegetables
Vegetables
Vegetables
Fish
BOLUS INSULINS ,[object Object],[object Object],[object Object],[object Object],[object Object]
CHARACTERISTICS OF BOLUS INSULIN  ,[object Object],[object Object],[object Object]
BOLUS INSULIN conts….. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Human Neutral Bolus Insulin ,[object Object],[object Object],[object Object]
Analogue Bolus Insulin… ,[object Object],[object Object],[object Object]
 
Humalog/Novolog versus Regular   ,[object Object],[object Object]
Isophane Basal and Quick acting Bolus……. ,[object Object],[object Object],[object Object],[object Object],[object Object]
What dose of Bolus insulin? ,[object Object],[object Object],[object Object],[object Object],[object Object]
BOLUS INSULIN TITRATION ,[object Object],[object Object],[object Object],[object Object]
 
BGL POFILE ON BASAL PLUS BOLUS INSULIN SCHEDULE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
INSULIN Rx PROGRAM
TROUBLE SHOOTING INSULIN PROBLEMS ,[object Object],[object Object],[object Object],[object Object]
 
STEP 6. ARE PROBLEMS WITH INSULIN LIKELY? ,[object Object],[object Object],[object Object],[object Object]
MEDICAL PROBLEMS ,[object Object],[object Object],[object Object]
PSYCHOLOGICAL PROBLEMS ?Causes ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
PSYCHOL.INSULIN RESISTANCE  -? Causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PSYCHOLOGICL INSULIN RESISTANCE ,[object Object],[object Object]
HOW TO RESOLVE THE CONCERNS? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
EMPLOYMENT AND INSURANCE ,[object Object],[object Object],[object Object],[object Object],[object Object]
CONCLUSIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
INSULIN IS NOT……
Initiate insulin therapy sooner rather than later, and treat to target ,[object Object],[object Object],[object Object],[object Object]
A PATIENT MIGHT SAY ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
THANK  YOU THANK YOU VERY MUCH

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