The document summarizes key aspects of immunity and the immune system. It describes how innate and acquired immunity function, with innate immunity providing nonspecific responses and acquired immunity providing specific responses after exposure. It outlines the roles of macrophages, T cells, B cells, antibodies, and humoral versus cell-mediated responses. The lymphatic system plays an active role in immunity. Blood groups are determined by antigens on red blood cells, and transfusions require matching blood types to avoid antibody-mediated destruction of transfused cells.
functioning of immune cells to provide protection of body against foreign par...zainabsarfraz4
it is the third line of defense which activate the T and B lymphocytes of immune system. both cells show adaptive immune response which means that exposure to the antigen or foreign particle is necessary to trigger adaptive immune response.T lymphocytes trigger cell mediated immune response and B lymphocytes trigger humoral immune response.T cells release cytokine and B cells produce antibodies and memory cells.
functioning of immune cells to provide protection of body against foreign par...zainabsarfraz4
it is the third line of defense which activate the T and B lymphocytes of immune system. both cells show adaptive immune response which means that exposure to the antigen or foreign particle is necessary to trigger adaptive immune response.T lymphocytes trigger cell mediated immune response and B lymphocytes trigger humoral immune response.T cells release cytokine and B cells produce antibodies and memory cells.
Difference between humoral and cell mediated immunity Dr. ihsan edan abdulkar...dr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Adaptive immunity is an immunity that occurs after exposure to an antigen either from a pathogen or a vaccination. This part of the immune system is activated when the innate immune response is insufficient to control an infection. In fact, without information from the innate immune system, the adaptive response could not be mobilized. There are two types of adaptive responses: the cell-mediated immune response, which is carried out by T cells, and the humoral immune response, which is controlled by activated B cells and antibodies.
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.).
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
Difference between humoral and cell mediated immunity Dr. ihsan edan abdulkar...dr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Adaptive immunity is an immunity that occurs after exposure to an antigen either from a pathogen or a vaccination. This part of the immune system is activated when the innate immune response is insufficient to control an infection. In fact, without information from the innate immune system, the adaptive response could not be mobilized. There are two types of adaptive responses: the cell-mediated immune response, which is carried out by T cells, and the humoral immune response, which is controlled by activated B cells and antibodies.
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism. Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.).
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
This presentation provides an overview of cell and humoral immunity, two important components of the immune system. Cell-mediated immunity is mediated by T cells, while humoral immunity is mediated by B cells and antibodies. The presentation discusses the different types of cells and molecules involved in each type of immunity, as well as the roles they play in protecting the body from infection.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. Mention types of immunity
Describe the components of blood and lymph, their
origins, and the role of hemoglobin in transporting oxygen
in RBCs
Understand the molecular basis of blood group.
14. The Immune System
An animal must
defend itself from the
many dangerous
pathogens it may
encounter in the
environment.
15.
16. Innate Immunity
Innate immunity
is present before
any exposure to
pathogens and is
effective from the
time of birth.
Involves
nonspecific
responses to
pathogens.
17. Acquired Immunity
Acquired immunity develops only after exposure
to inducing agents such as microbes, toxins, or
other foreign substances.
Involves a very specific response to pathogens.
18.
19.
20. Humoral vs. Cell-Mediated
Response
Acquired immunity includes two branches:
The humoral immune response involves the activation
and clonal selection of B cells, resulting in the
production of secreted antibodies.
The cell-mediated immune response involves the
activation and clonal selection of cytotoxic T cells.
24. Types of immunity-Role of
leucocytes
Neutrophils Lyzozymes Provided by Provided by
Basophils Interferon T- cells B-cells
Eosinophils Complement system
Macrophages Stomach acid Plasma cells
NK- cells Tear & saliva
Phagocytosis Skin Antibodies
Innate
Cellular Humoral
Acquired
Cellular Humoral
25.
26. Naturally acquired active immunity would
be most likely acquired through which of
the following processes?
a. Vaccination
b. Drinking colostrum
c. Natural birth
d. Infection with disease causing organism
followed by recovery.
27. Which of the following convey the longest
lasting immunity to an infectious agent?
a. Naturally acquired passive immunity
b. Artificially acquired passive immunity
c. Naturally acquired active immunity
d. All of these
28. Answer is “c
Active immunity can last a lifetime or for a period of
weeks, months or years, depending on how long the
antibodies persist. So only one option in the choice
contain active immunity as a part of answer.
29. Which of the following substances will
not stimulate an immune response
unless they are bound to a larger
molecule?
a. Antigen
b. Virus
c. Hapten
d. Miligen
30. The answer is “c”
Hapten is a small molecule; they can
act as antigen if it binds to a larger
protein molecule.
31. B and T cells are produced by stem cells that
are formed in:
a. Bone marrow
b. The liver
c. The circulatory system
d. The spleen
e. The lymph nodes
32. B cells mature in the……….. while T cells
mature in the
a. Thymus/bone marrow and gut associated
lymphoid tissue (GALT)
b. Spleen/bone marrow and GALT
c. Bone marrow and GALT/Thymus
d. Liver/Kidneys
33.
34. Fever is caused by:
1. Toxins on the surface of viruses.
2. Release of histamines by damaged cells.
3. Your own body’s accumulated toxins.
4. Your body’s pyrogens signaling the
hypothalamus.
35. Based on what you know about non-specific
defenses, what’s the best way to treat a
cut in your skin?
1. Leave it exposed to open air.
2. Wash it, and cover it with a clean
bandage.
3. Rub it with dirt.
36. Major players
The major players in the immune system include:
Macrophage
T cells (helper, cytotoxic, memory)
B cells (plasma, memory)
Antibodies
37.
38.
39. Phagocytic Cells
Macrophages, a specific type of phagocyte, can be
found migrating through the body.
Also found in various organs of the lymphatic system.
40. The Immune System
Immune cells,
red blood cells,
and other
white blood
cells are
derived from
multipotential
stem cells in
the bone
marrow.
41. The Immune System
Lymphocytes arise
from stem cells in
the bone marrow.
Newly formed
lymphocytes are all
alike, but they later
develop into B cells
or T cells, depending
on where they
continue their
maturation.
42. Cell mediated immunity is carried out by…………..
while humoral immunity is mainly carried out
by………………..
a. B cells/T cells
b. Epitopes/Antigens
c. T cells/B cells
d. Antibodies/Antigens
e. Antibodies/Phagocytes
43. A foreign protein that enters
the body is an:
1. antibiotic.
2. antigen.
3. antibody.
4. anti-inflammatory.
44. The specific immune response
is triggered when:
1. A macrophage delivers an antigen to a T-
helper cell.
2. Plasma cells begin making antibodies.
3. Pyrogen stimulates a fever.
4. Clonal selection of B-cells occurs.
45. The Immune System
As B and T cells are maturing in the bone marrow and
thymus, their antigen receptors are tested for possible self-
reactivity.
Lymphocytes bearing receptors for antigens already
present in the body are destroyed by apoptosis or
rendered nonfunctional.
47. The Lymphatic System
The lymphatic
system plays an
active role in
defending the body
from pathogens.
48.
49.
50. Blood Groups and
Transfusions
Certain antigens on red blood cells determine whether
a person has type A, B, AB, or O blood.
Antibodies to nonself blood types already exist in the
body.
Transfusion with incompatible blood leads to
destruction of the transfused cells.
51. References
• Medical Physiology by Guyton 12th Edition
• Review of Medical Physiology by Ganong 23rd
Edition