The innate immune system is genetically based and provides nonspecific protection against all antigens. It relies on surface barriers like skin and mucosa, as well as cells such as macrophages, mast cells, and natural killer cells. The adaptive immune system involves antigen presenting cells that process and present antigens to lymphocytes. Central immune organs include the red bone marrow, which produces hematopoietic cells, and the thymus, where T lymphocytes mature. Peripheral organs are the spleen, lymph nodes, and mucosa-associated lymphoid tissue.

1. Immune system
Histophysiology

4. Innate Immunity
The innate immunity system is
what we are born with
It is nonspecific
All antigens are attacked equally.
It is genetically based
We pass it on to our offspring.
Surface Barriers or Mucosal
Immunity
1.The first the most important
barrier is the skin and mucosa.
2. Secretion on surface of skin
and mucosa
3. Epithelial barrier
4. Macrophages, mast cells
5. Blood cells: platelets, Nph, Eo,
NK

5. Cells mediating immunity

11. Antigen presenting cells

12. Antigen processing and presentation

13. Diversity of dendritic cells

14. Organs of immune system
Central organs:
-Red bone marrow
- Thymus
Peripheral
-Spleen
- Lymph nodes
- MALT

15. Red bone marrow
Myeloid tissue
-Hematopoietic cells
-Microenvironment

17. Key morphological features
1. Sinusoidal capillaries
2. Megakaryocytes
3. Adipocytes
4. Many immature and
maturing cells

18. Cells maturation and kinetics in RBM

21. Thymus
1. Type of structure is
parenchymal lobulated
2. Parenchyme is
lymphoid tissue.
3. Each lobule consists of
cortex and medulla.
4. In medulla there are
Hassal`s bodies

23. Selection of lymphocytes in thymus

26. Types of T-lymphocytes

27. Regulatory T cells:
friend or foe in immunity to infection?

28. Spleen
1. Type of structure is parenchymal
2. Stroma is composed by capsule
and trabecules (DCT +SM + ElF)
3. Parenchyme includes red and
white pulp.
3. White pulp is lymphoid tissue,
forms LSh and LF.
4. Red pulp includes sinusoids and
cords.

29. Spleen

30. Spleen

31. Lymph nodes

32. Lymph node
1. Type of structure is parenchymal
2. Stroma is composed by capsule
and trabecules (DCT)
3. Parenchyme includes cortex and
medulla.
4. Cortex includes LFs and
paracortical zone.
5. Medulla includes sinuses and
medullary cords.

33. Lymph node

35. Funny humoral immunity