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THE ORGANS OF THE  IMMUNE SYSTEM
 
Lymphocytes
 
Lymphocytes
SOURCE OF LYMPHOCYTES Fetus Primary Lymphoid  Organs Secondary Lymphoid  Organs Adult
SOURCE OF LYMPHOCYTES
 
SOURCE OF LYMPHOCYTES
HUMAN THYMUS
PRIMARY LYMPHOID ORGANS THYMUS (T cell maturation) (> lymphocytes) (< lymphocytes)
The functional thymus consists of two cell populations; the stromal cells and the thymocytes. The stromal cells include (1) the subcapsular epithelial cells;  (2) the cortical epithelial cells; (3) the medullary epithelial cells; (4) macrophages; and (5) dendritic cells of bone marrow origin. (From Kierszenbaum AL: Histology and cell biology: an introduction to pathology, St Louis, 2002, Mosby.)
MHC-dependiente
Effects of Adult Thymectomy on Immune Response
CHICKEN THYMUS AND  BURSA OF FABRICIUS
 
BURSA OF FABRICIUS (B cell maturation) follicle lumen Cortex (lymphocytes, M Ø, plasma cells) medulla
PEYER’S PATCHES Group I  (90% Ileum ) Ruminants, Pigs, Horses, Dogs, Humans.  Group II  Illeum/Jejunum) Rabbits, Rodents.
When stimulated by antigen, immunoglobulin A (IgA)-producing B cells are produced in inductive sites, such as the Peyer’s patches.
The role of M cells as antigen-processing cells in the intestinal wall. Antigen that enters enterocytes is usually rapidly degraded in lysosomes. Antigen that enters M cells is not degraded. It may be presented directly to intraepithelial lymphocytes within the M. Yersinia, M. tuberculosis, Listeria, reovirus , Salmonella.
Structure of the two different types of Peyer’s patch (PP) in sheep. A, An ileal PP at age 8 weeks. B, A PP from the jejunum, also at 8 weeks. Original magnification ×32. (From Reynolds JD, Morris B: Eur J Immunol 13:631, 1983.)
SECONDARY LYMPHOID ORGANS LYMPH NODE
SECONDARY LYMPHOID ORGANS LYMPH NODE
(B cells) (stimulated) (T cells) (unstimulated) (B cells, macrophages, plasma cells) SECONDARY LYMPHOID ORGANS LYMPH NODE
SECONDARY LYMPHOID ORGANS LYMPH NODE secondary follicle primary follicle medulla subcapsular sinus dendritic cells
Circulation of Lymphocytes
 
HIGH ENDOTHELIAL VENULES
 
HIGH ENDOTHELIAL VENULES
 
HIGH ENDOTHELIAL VENULES
 
 
RP WP B cell follicle PLS Marginal Zone SPLEEN
 
SPLEEN
PERIARTERIOLAR LYMPHOID SHEATS (PALS) B cells T cells arteriole
 
 
In Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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