Common diseases of ear, nose and throat prevalent in community level populaton of Nepal.
These are the most common conditions that the people present in primary health center level.
The slide includes the short introduction and management of those conditions and primary preventive measures in case they are far away from well equipped hospitals.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Contents
• Introduction
• Historical perspective
• Classification of different types of imaging techniques
• General application of imaging in orthopaedics
• Conclusion
3. INTRODUCTION
• A veritable tool in the evaluation of surgical patients.
• Many surgical diagnoses can be made with clinical assessment.
However, radiological investigations remains vital to the diagnosis,
preparation and follow up of patients
• A myriad of imaging options are available.
• Initial application of radiography lay in the demonstration of fractures
and radio-opaque foreign bodies.
• Subsequent parallel development of Radiology and Orthopaedics had
broaden the scope.
• Today, high precision interventional therapeutic procedure can be
carried out.
4. HISTORICAL PERSPECTIVE
• Wilhelm Conrad Rontgen: discovered x-rays(1895). Nobel prize in
1901 (father of radiology).
• 1920: use of contrast for x ray studies
• 1950s: nuclear medicine was born
• 1970s: ultrasound came into use
• Sir Godfrey Hounsfield invented CT in 1975.
5. USES OF RADIOLOGICAL TECHNIQUES
• To aid diagnosis of a medical and/or surgical disorder
• To guide a surgical procedure
• Monitoring
• Interventional radiological techniques
6. CLASSIFICATION OF IMAGING TECHNIQUES
Current techniques in practice of orthopaedics include:
• Clinical photograph
• X-rays (plain radiographs)
• Fluoroscopy
• Ultrasound
• Computed tomography
• Magnetic resonant imaging
• Radionuclide scanning
• Bone densitometry
7. CLINICAL PHOTOGRAPH
• First line imaging
• For documentation and monitoring
• Uses
In trauma with soft tissue
involvement
In management of clubfoot pre-,
intra- and post correction
Angular deformities of the limb,
etc
9. X-RAYS (PLAIN RADIOGRAPHY)
Definition
• High energy radiation which undergo differential absorption by
tissues as they pass through the body
• Generated via interactions of the accelerated electrons with electrons
of tungsten nuclei within the tube anode.
• 2 types of x-rays generated: Characteristic radiation and
Bremsstrahlung radiation.
11. • Quantity of x-rays generated: directly proportional to number of
moving electrons.
• Quality of x-rays generated: proportional to the speed of the
electrons
• 2 outcomes when x-rays interacts with matter
1. Photoelectric absorption
2. Compton scattering
12. Basics of X-ray physics
• Travel in straight lines
• Body parts further away
from the detector are
magnified compared with
those that are closer and
vice versa.
• A source tat is too near the
patient will further
exaggerate the size of
structures nearest to that
sources.
13. Tissue densities
• an x-ray image is a map of x-
ray attenuation
• Attenuation of x-rays is
variable depending on
density and thickness of
tissues
• Describing x-ray
abnormalities in terms of
density may help in
determining the tissue
involved.
• The greatest contrast is
found in areas of greatest
difference in density of
adjacent structures.
14. Uses
• Invaluable investigation in orthopaedics
• Have wide application such as
Diagnosis
Planning of surgery
Intraoperative assessment of fixation of fractures
Monitoring of treatment and healing
Occasionally for interventions eg. Vertebroplasty, SNRB.
Advantages
• Cheap
• Easily available
• Good in assessing bone due to its high calcium content and intrinsic
contrast.
15. COMPUTED TOMOGRAPHY(CT) SCAN
• One of the major advances in radiology
in recent years.
• Uses a computer to create an image
from an integration of multiple xrays
exposures taken in a circle round the
patients.
• Heavy ionizing radiation dose.
16. • Attenuation: amount of x-rays absorbed by tissues
(different for different tissues)
• Hounsfield units describe the attenuation co-
efficient of tissues
• Bone=1000 Hu
• Water= 0 Hu
• Air= -1000 Hu
• There is a much wider range of attenuation co-
efficient than the greyscale a human eye can
perceive
• Different windows for different tissue types
allowing the whole range of attenuation to be
displayed and improves overall detail.
17. Advantages
• Reconstruction possible in any plane desired
• Good for surgical planning in complex fractures-
3D reconstruction
• Exellent resolution of cortical bone
• Better soft tissue attenuation than plain x-ray
• CT guided biopsy
• CT with contrast
Disadvantages
• Availability
• High resolution dose
• Claustrophobia
18. MRI
• Newest of the imaging techniques
• Does not use ionizing radiation
• Principle: body tissues consists of
protons/electrons. In a strong uniform
field such as MRI scanner, these nuclei
align themselves with the main magnetic
field.
A brief radiofrequency, pulse is applied
to alter the motion of the nuclei. When
removed, the nuclei realign with the
main magnetic field, emitting energy(RF
signal).
19. • T2 signal
• Time taken for the protons to loose
their coherence once radiofrequency
turned off
• Water rich tissues have longer T2 time
as they contain more protons
• Hence they release energy for a
longer time and give a high signal
• T1 signal
• Time taken for 63% of the protons to
return to the longitudinal spin axis
20. • Repitition time (TR) (msec)
• The time between repetition of pulses
• T2 images have very high TR time
• Otherwise the water dense tissues will not have released enough
energy to detect pulses are given frequency though, fat appears
white rather than water.
• Time to echo (TE) (msec)
• Time from when the pulse is stopped to when the signal is
measured.
21. • Differential sequences
• T1 weighted- short TR (TR<1000 ms), short TE(<60 ms)
fat=bright
fluid= dark
defining anatomy
• T2 weighted- long TR (TR>1000ms), long TE (TE>60 sec)
Fluid= bright
Defining pathology
• Proton density (PD)- long TR(TR>1000ms), short TE(TE<60ms)
• Part T1, Part T2
• Useful in certain situations e.g. the meniscus
22. • Contrast (Gadolinium)
• High net magnetic moment
• More strongly affects hydrogen
ions in close proximity to the
contrast.
• Enhances the image and results in
high signal on T1 scans as well.
• Shows pathologic fluid collections
better.
23. • Advantages
• No ionizing radiation
• High quality image
• Can be used with contrast
• Abscesses and intra-articular pathology
• Disadvantages
• Claustrophobia
• Noisy
• Not tolerated well by children
• Availability
• Contraindication to MRI e.g. aneurysm
clips and pace makers, internal hearing
aids,
• Metal artifacts: MARS sequence
• Over diagnosis of asymptomatic
24. ULTRASOUND
• Second most common method of
imaging
• Relies on high frequency sound waves
generated by a transducer containing
piezoelectric material
• Principle:
generated sound waves are
reflected by tissue interfaces and, by
ascertaining the direction and the time
taken for a pulse to return, it is possible
to form an image.
25. Acoustic impedance
• Impedance between tissues creates echo
• Minimal differences between fat and
muscle(most waves pass through)
• Large difference between air and
skin(most waves reflected-use gel)
• High impedance=bright
• Low impedance= dark
26. Advantages
• Non ionizing
• Cheap
• Portable
• Dynamic imaging
• Very good for cystic structures
• Biopsy, injection, aspiration
Disadvantages
• Highly operator dependent
• Only for superficial structures (cannot
penetrate cortical bone)
• Limited field of fiew
• Poor resolution comparatively
27. BONE SCAN(RADIONUCLIDE IMAGING)
• Gamma rays emitted from a radioactive isotope
of technetium 99 bound to a phosphate to give a
map of blood flow and osteoblastic activity
Technetium-99
• Unstable radioisotope
• Emits gamma rays
• Derived from the decay of molybdenum 99
• Short half life of 6 hours
• Excreted via kidney (bladder hydration and
28. Mechanism of action
• Technetium-99 is attached to methyl
diphosphonate(MDP) when injected iv
• The MDP interact with HA crystals in bone-
depending on adequate vascularity to the area
in question.
• Because HA crystals are generated by
osteoblasts mineralizing bone it is a direct
reflection of osteoblastic activity.
• The gamma rays emitted by the T-99 are dected
by a gamma camera
• A digital image is created giving a map of blood
flow and osteoblastic activity
29. Radionuclide imaging….
3 phases of triple bone scan
• Vascular phase (1-2min)
• Blood pool phase (3-5 min)
• Static phase(4 hrs)
30. Radionuclide imaging…
• Single photon emission computed tomography-CT (SPECT-CT)
• Gamma camera with CT component on the same scanner
• Multi-planar imaging
• Increasing resolution, decrease noise and increase localization
• Positron emission tomography-CT (PET-CT)
• Exploiting increase metabolic rato of tumors i.e glucose
consumption
• E.g deoxyglucose labelled 18 Fluorine (1/2 life-112 min)
31. Radionuclide imaging…
• WBC scan
• Labelling patient’s own WBC with radioactive tracer such as
indium
• Accumulation in the reticuloendothelial system e.g. bone marrow
liver and spleen but also areas of active infection
• Hybrid PET-MRI
• Potential increase bone metastasis assessment and response to
treatment
32. Useful for
• Tumors (metastatic and primary esp in spine)
• Infection-osteomyelitis
• Stress fractures
• Prosthetic loosening/pain
• Paget’s disease
Disadvantages
• Poor specificity although very sensitive
• Radiation dose is fairly high
• False negative in areas of low blood supply-e.g avascular bone, lytic
tumors
33. DEXA scan
• Dual energy x-ray absorbimetry
• Utilizes xrays of different energies
• Absorbed in different proportions by
bone and soft tissues
• Used to assess bone mineral density
34. Result interpretation
• Units of bone mineral density are g/cm3
• Values are related to the peak bone mass density of a young adult or
matched by age
• The T score represents comparison with peak BMD of a young adult
• The z score represents the age-matched score
• Sex and race are matched in both (only difference is age matching in
the Z score)
• The T score is used to determine whether there is osteoporosis
• The Z score is used to assess whether the reduced BMD is related to
another cause i.e lower than expected for age
35. WHO criteria for osteoporosis relies
on T score
• 0 to -1 =normal
• -1 to -2.5= osteopenia
• <-2.5 = osteoporosis
• <-2.5 +fragility fracture=severe
osteoporosis
Disadvantages
• No differentiation between cortical
and cancellous density
• Falsely high BMD in fractured
sclerotic vertebrae and degenerate
36. GENERAL APPLICATION OF IMAGING IN
ORTHOPAEDICS
General applications
• Diagnosis, classification and staging of diseases
• Preoperative planning and templating
• Intraoperative monitoring
• Therapeutic purposes
• Monitoring of treatment and healing process
37. Diagnosis
• Almost all the modalities are used to make or confirm diagnosis
• Plain radiography plays an invaluable role especially in trauma
• CT scan usuallu augments plain radiograph, though plays important
role in complex trauma
• Biopsies can be US, fluoroscopic or CT-guided
• DDH, Joint collection by US scanning
• Bone scans
• Bone densitometry
38. Pre operative planning
• Plain radiographs, CT scans with 3D reconstruction and MRI
• Plain radiographs used in templating
• MRI especially in spine, ligamentous injuries, oncology
39. Intraoperative
• Fluoroscopy in fracture fixations
• Limb reconstructions
• Corrective osteotomies
• Spine fixations
• Minimally invasive surgeries and closed reductions and fixation
41. Monitoring
• Fracture healing and status of the implants
• Endoprosthesis
• Effect of treatment e.g rickets, osteoporosis
42. Risks
• Cell death and distorted replication
• Cancers-Thyroid (85% of papillary cancers –radiation related), skin
and breast cancers
• Cataracts
Reducing risk(measures)
• Justify, optimize (ALARA), limit
• PPE
• Scatter
The annual whole body dose equivalent limit for occupationally
exposed persons is 20mSv
43. Take home message
• Imaging is paramount in orthopaedic practice
• Sound knowledge and broad understanding of radiological techniques
as they applied to orthopaedics is paramount for the orthopaedic
surgeons
44. References
• Ramachandran M, Ramachandran N and Saifuddin A. imaging
techniques.
• Berquist TH. Imaging of Orthopaedic Fixation Devices and Prostheses.
• Rockwood and Green’s Fractures in Adults, 9th edition
Editor's Notes
Characteristic xray generation
When a high energy electron collides with an inner shell electron both are ejected from the tungsten atom leaving a ‘Hole’ in the inner layer. This is filled by an outer shell electron with a loss of energy emitted as an x-ray photon.
Bremssstrahlung xray generation
When an electron passes near the nucleus it is slowed and its path is deflected. Energy lost is emitted as a bremsstrahlung xray photon
Aka braking radiation
Approx 80% of the population of xrays within the xray beam consists of xray generated in this way
By applying a voltage then reversing the voltage, contraction and expansion of the crystals surface is created
This generate a compression wave- the ultrasound wave
Pulse echo from tissue return to receiving transducer
This again creates a voltage which is used to generate an image
Depth of the structures calculated by time taken for the wave to be reflected.
Vascular phase shows arterial flow and hyper perfusion
Blood pool phase shows bone and soft tissue hyperemia
Static phase shows soft tissue activity has cleared leaving only bone activity