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IMAGING TECHNIQUES
Presented by
Dr Binod Chaudhary
Department of Orthopaedics
WRH, PoAHS
Contents
• Introduction
• Historical perspective
• Classification of different types of imaging techniques
• General application of imaging in orthopaedics
• Conclusion
INTRODUCTION
• A veritable tool in the evaluation of surgical patients.
• Many surgical diagnoses can be made with clinical assessment.
However, radiological investigations remains vital to the diagnosis,
preparation and follow up of patients
• A myriad of imaging options are available.
• Initial application of radiography lay in the demonstration of fractures
and radio-opaque foreign bodies.
• Subsequent parallel development of Radiology and Orthopaedics had
broaden the scope.
• Today, high precision interventional therapeutic procedure can be
carried out.
HISTORICAL PERSPECTIVE
• Wilhelm Conrad Rontgen: discovered x-rays(1895). Nobel prize in
1901 (father of radiology).
• 1920: use of contrast for x ray studies
• 1950s: nuclear medicine was born
• 1970s: ultrasound came into use
• Sir Godfrey Hounsfield invented CT in 1975.
USES OF RADIOLOGICAL TECHNIQUES
• To aid diagnosis of a medical and/or surgical disorder
• To guide a surgical procedure
• Monitoring
• Interventional radiological techniques
CLASSIFICATION OF IMAGING TECHNIQUES
Current techniques in practice of orthopaedics include:
• Clinical photograph
• X-rays (plain radiographs)
• Fluoroscopy
• Ultrasound
• Computed tomography
• Magnetic resonant imaging
• Radionuclide scanning
• Bone densitometry
CLINICAL PHOTOGRAPH
• First line imaging
• For documentation and monitoring
• Uses
In trauma with soft tissue
involvement
In management of clubfoot pre-,
intra- and post correction
Angular deformities of the limb,
etc
X-RAYS (PLAIN RADIOGRAPHY)
Electromagnetic radiation
• Travel at speed of light ~3,00,000 km/s
• Not affected by electric or magnetic fields
• Travel through vaccum
X-RAYS (PLAIN RADIOGRAPHY)
Definition
• High energy radiation which undergo differential absorption by
tissues as they pass through the body
• Generated via interactions of the accelerated electrons with electrons
of tungsten nuclei within the tube anode.
• 2 types of x-rays generated: Characteristic radiation and
Bremsstrahlung radiation.
Characteristic Radiation Bremsstrahlung radiation
• Quantity of x-rays generated: directly proportional to number of
moving electrons.
• Quality of x-rays generated: proportional to the speed of the
electrons
• 2 outcomes when x-rays interacts with matter
1. Photoelectric absorption
2. Compton scattering
Basics of X-ray physics
• Travel in straight lines
• Body parts further away
from the detector are
magnified compared with
those that are closer and
vice versa.
• A source tat is too near the
patient will further
exaggerate the size of
structures nearest to that
sources.
Tissue densities
• an x-ray image is a map of x-
ray attenuation
• Attenuation of x-rays is
variable depending on
density and thickness of
tissues
• Describing x-ray
abnormalities in terms of
density may help in
determining the tissue
involved.
• The greatest contrast is
found in areas of greatest
difference in density of
adjacent structures.
Uses
• Invaluable investigation in orthopaedics
• Have wide application such as
Diagnosis
Planning of surgery
Intraoperative assessment of fixation of fractures
Monitoring of treatment and healing
Occasionally for interventions eg. Vertebroplasty, SNRB.
Advantages
• Cheap
• Easily available
• Good in assessing bone due to its high calcium content and intrinsic
contrast.
COMPUTED TOMOGRAPHY(CT) SCAN
• One of the major advances in radiology
in recent years.
• Uses a computer to create an image
from an integration of multiple xrays
exposures taken in a circle round the
patients.
• Heavy ionizing radiation dose.
• Attenuation: amount of x-rays absorbed by tissues
(different for different tissues)
• Hounsfield units describe the attenuation co-
efficient of tissues
• Bone=1000 Hu
• Water= 0 Hu
• Air= -1000 Hu
• There is a much wider range of attenuation co-
efficient than the greyscale a human eye can
perceive
• Different windows for different tissue types
allowing the whole range of attenuation to be
displayed and improves overall detail.
Advantages
• Reconstruction possible in any plane desired
• Good for surgical planning in complex fractures-
3D reconstruction
• Exellent resolution of cortical bone
• Better soft tissue attenuation than plain x-ray
• CT guided biopsy
• CT with contrast
Disadvantages
• Availability
• High resolution dose
• Claustrophobia
MRI
• Newest of the imaging techniques
• Does not use ionizing radiation
• Principle: body tissues consists of
protons/electrons. In a strong uniform
field such as MRI scanner, these nuclei
align themselves with the main magnetic
field.
A brief radiofrequency, pulse is applied
to alter the motion of the nuclei. When
removed, the nuclei realign with the
main magnetic field, emitting energy(RF
signal).
• T2 signal
• Time taken for the protons to loose
their coherence once radiofrequency
turned off
• Water rich tissues have longer T2 time
as they contain more protons
• Hence they release energy for a
longer time and give a high signal
• T1 signal
• Time taken for 63% of the protons to
return to the longitudinal spin axis
• Repitition time (TR) (msec)
• The time between repetition of pulses
• T2 images have very high TR time
• Otherwise the water dense tissues will not have released enough
energy to detect pulses are given frequency though, fat appears
white rather than water.
• Time to echo (TE) (msec)
• Time from when the pulse is stopped to when the signal is
measured.
• Differential sequences
• T1 weighted- short TR (TR<1000 ms), short TE(<60 ms)
fat=bright
fluid= dark
defining anatomy
• T2 weighted- long TR (TR>1000ms), long TE (TE>60 sec)
Fluid= bright
Defining pathology
• Proton density (PD)- long TR(TR>1000ms), short TE(TE<60ms)
• Part T1, Part T2
• Useful in certain situations e.g. the meniscus
• Contrast (Gadolinium)
• High net magnetic moment
• More strongly affects hydrogen
ions in close proximity to the
contrast.
• Enhances the image and results in
high signal on T1 scans as well.
• Shows pathologic fluid collections
better.
• Advantages
• No ionizing radiation
• High quality image
• Can be used with contrast
• Abscesses and intra-articular pathology
• Disadvantages
• Claustrophobia
• Noisy
• Not tolerated well by children
• Availability
• Contraindication to MRI e.g. aneurysm
clips and pace makers, internal hearing
aids,
• Metal artifacts: MARS sequence
• Over diagnosis of asymptomatic
ULTRASOUND
• Second most common method of
imaging
• Relies on high frequency sound waves
generated by a transducer containing
piezoelectric material
• Principle:
generated sound waves are
reflected by tissue interfaces and, by
ascertaining the direction and the time
taken for a pulse to return, it is possible
to form an image.
Acoustic impedance
• Impedance between tissues creates echo
• Minimal differences between fat and
muscle(most waves pass through)
• Large difference between air and
skin(most waves reflected-use gel)
• High impedance=bright
• Low impedance= dark
Advantages
• Non ionizing
• Cheap
• Portable
• Dynamic imaging
• Very good for cystic structures
• Biopsy, injection, aspiration
Disadvantages
• Highly operator dependent
• Only for superficial structures (cannot
penetrate cortical bone)
• Limited field of fiew
• Poor resolution comparatively
BONE SCAN(RADIONUCLIDE IMAGING)
• Gamma rays emitted from a radioactive isotope
of technetium 99 bound to a phosphate to give a
map of blood flow and osteoblastic activity
Technetium-99
• Unstable radioisotope
• Emits gamma rays
• Derived from the decay of molybdenum 99
• Short half life of 6 hours
• Excreted via kidney (bladder hydration and
Mechanism of action
• Technetium-99 is attached to methyl
diphosphonate(MDP) when injected iv
• The MDP interact with HA crystals in bone-
depending on adequate vascularity to the area
in question.
• Because HA crystals are generated by
osteoblasts mineralizing bone it is a direct
reflection of osteoblastic activity.
• The gamma rays emitted by the T-99 are dected
by a gamma camera
• A digital image is created giving a map of blood
flow and osteoblastic activity
Radionuclide imaging….
3 phases of triple bone scan
• Vascular phase (1-2min)
• Blood pool phase (3-5 min)
• Static phase(4 hrs)
Radionuclide imaging…
• Single photon emission computed tomography-CT (SPECT-CT)
• Gamma camera with CT component on the same scanner
• Multi-planar imaging
• Increasing resolution, decrease noise and increase localization
• Positron emission tomography-CT (PET-CT)
• Exploiting increase metabolic rato of tumors i.e glucose
consumption
• E.g deoxyglucose labelled 18 Fluorine (1/2 life-112 min)
Radionuclide imaging…
• WBC scan
• Labelling patient’s own WBC with radioactive tracer such as
indium
• Accumulation in the reticuloendothelial system e.g. bone marrow
liver and spleen but also areas of active infection
• Hybrid PET-MRI
• Potential increase bone metastasis assessment and response to
treatment
Useful for
• Tumors (metastatic and primary esp in spine)
• Infection-osteomyelitis
• Stress fractures
• Prosthetic loosening/pain
• Paget’s disease
Disadvantages
• Poor specificity although very sensitive
• Radiation dose is fairly high
• False negative in areas of low blood supply-e.g avascular bone, lytic
tumors
DEXA scan
• Dual energy x-ray absorbimetry
• Utilizes xrays of different energies
• Absorbed in different proportions by
bone and soft tissues
• Used to assess bone mineral density
Result interpretation
• Units of bone mineral density are g/cm3
• Values are related to the peak bone mass density of a young adult or
matched by age
• The T score represents comparison with peak BMD of a young adult
• The z score represents the age-matched score
• Sex and race are matched in both (only difference is age matching in
the Z score)
• The T score is used to determine whether there is osteoporosis
• The Z score is used to assess whether the reduced BMD is related to
another cause i.e lower than expected for age
WHO criteria for osteoporosis relies
on T score
• 0 to -1 =normal
• -1 to -2.5= osteopenia
• <-2.5 = osteoporosis
• <-2.5 +fragility fracture=severe
osteoporosis
Disadvantages
• No differentiation between cortical
and cancellous density
• Falsely high BMD in fractured
sclerotic vertebrae and degenerate
GENERAL APPLICATION OF IMAGING IN
ORTHOPAEDICS
General applications
• Diagnosis, classification and staging of diseases
• Preoperative planning and templating
• Intraoperative monitoring
• Therapeutic purposes
• Monitoring of treatment and healing process
Diagnosis
• Almost all the modalities are used to make or confirm diagnosis
• Plain radiography plays an invaluable role especially in trauma
• CT scan usuallu augments plain radiograph, though plays important
role in complex trauma
• Biopsies can be US, fluoroscopic or CT-guided
• DDH, Joint collection by US scanning
• Bone scans
• Bone densitometry
Pre operative planning
• Plain radiographs, CT scans with 3D reconstruction and MRI
• Plain radiographs used in templating
• MRI especially in spine, ligamentous injuries, oncology
Intraoperative
• Fluoroscopy in fracture fixations
• Limb reconstructions
• Corrective osteotomies
• Spine fixations
• Minimally invasive surgeries and closed reductions and fixation
Therapeutic/interventional procedures
• Arthrography/Diagnostic-therapeutic injections
• Facet injections
• Discography
• Vertebroplasty
Monitoring
• Fracture healing and status of the implants
• Endoprosthesis
• Effect of treatment e.g rickets, osteoporosis
Risks
• Cell death and distorted replication
• Cancers-Thyroid (85% of papillary cancers –radiation related), skin
and breast cancers
• Cataracts
Reducing risk(measures)
• Justify, optimize (ALARA), limit
• PPE
• Scatter
The annual whole body dose equivalent limit for occupationally
exposed persons is 20mSv
Take home message
• Imaging is paramount in orthopaedic practice
• Sound knowledge and broad understanding of radiological techniques
as they applied to orthopaedics is paramount for the orthopaedic
surgeons
References
• Ramachandran M, Ramachandran N and Saifuddin A. imaging
techniques.
• Berquist TH. Imaging of Orthopaedic Fixation Devices and Prostheses.
• Rockwood and Green’s Fractures in Adults, 9th edition
IMAGING TECHNIQUES

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IMAGING TECHNIQUES

  • 1. IMAGING TECHNIQUES Presented by Dr Binod Chaudhary Department of Orthopaedics WRH, PoAHS
  • 2. Contents • Introduction • Historical perspective • Classification of different types of imaging techniques • General application of imaging in orthopaedics • Conclusion
  • 3. INTRODUCTION • A veritable tool in the evaluation of surgical patients. • Many surgical diagnoses can be made with clinical assessment. However, radiological investigations remains vital to the diagnosis, preparation and follow up of patients • A myriad of imaging options are available. • Initial application of radiography lay in the demonstration of fractures and radio-opaque foreign bodies. • Subsequent parallel development of Radiology and Orthopaedics had broaden the scope. • Today, high precision interventional therapeutic procedure can be carried out.
  • 4. HISTORICAL PERSPECTIVE • Wilhelm Conrad Rontgen: discovered x-rays(1895). Nobel prize in 1901 (father of radiology). • 1920: use of contrast for x ray studies • 1950s: nuclear medicine was born • 1970s: ultrasound came into use • Sir Godfrey Hounsfield invented CT in 1975.
  • 5. USES OF RADIOLOGICAL TECHNIQUES • To aid diagnosis of a medical and/or surgical disorder • To guide a surgical procedure • Monitoring • Interventional radiological techniques
  • 6. CLASSIFICATION OF IMAGING TECHNIQUES Current techniques in practice of orthopaedics include: • Clinical photograph • X-rays (plain radiographs) • Fluoroscopy • Ultrasound • Computed tomography • Magnetic resonant imaging • Radionuclide scanning • Bone densitometry
  • 7. CLINICAL PHOTOGRAPH • First line imaging • For documentation and monitoring • Uses In trauma with soft tissue involvement In management of clubfoot pre-, intra- and post correction Angular deformities of the limb, etc
  • 8. X-RAYS (PLAIN RADIOGRAPHY) Electromagnetic radiation • Travel at speed of light ~3,00,000 km/s • Not affected by electric or magnetic fields • Travel through vaccum
  • 9. X-RAYS (PLAIN RADIOGRAPHY) Definition • High energy radiation which undergo differential absorption by tissues as they pass through the body • Generated via interactions of the accelerated electrons with electrons of tungsten nuclei within the tube anode. • 2 types of x-rays generated: Characteristic radiation and Bremsstrahlung radiation.
  • 11. • Quantity of x-rays generated: directly proportional to number of moving electrons. • Quality of x-rays generated: proportional to the speed of the electrons • 2 outcomes when x-rays interacts with matter 1. Photoelectric absorption 2. Compton scattering
  • 12. Basics of X-ray physics • Travel in straight lines • Body parts further away from the detector are magnified compared with those that are closer and vice versa. • A source tat is too near the patient will further exaggerate the size of structures nearest to that sources.
  • 13. Tissue densities • an x-ray image is a map of x- ray attenuation • Attenuation of x-rays is variable depending on density and thickness of tissues • Describing x-ray abnormalities in terms of density may help in determining the tissue involved. • The greatest contrast is found in areas of greatest difference in density of adjacent structures.
  • 14. Uses • Invaluable investigation in orthopaedics • Have wide application such as Diagnosis Planning of surgery Intraoperative assessment of fixation of fractures Monitoring of treatment and healing Occasionally for interventions eg. Vertebroplasty, SNRB. Advantages • Cheap • Easily available • Good in assessing bone due to its high calcium content and intrinsic contrast.
  • 15. COMPUTED TOMOGRAPHY(CT) SCAN • One of the major advances in radiology in recent years. • Uses a computer to create an image from an integration of multiple xrays exposures taken in a circle round the patients. • Heavy ionizing radiation dose.
  • 16. • Attenuation: amount of x-rays absorbed by tissues (different for different tissues) • Hounsfield units describe the attenuation co- efficient of tissues • Bone=1000 Hu • Water= 0 Hu • Air= -1000 Hu • There is a much wider range of attenuation co- efficient than the greyscale a human eye can perceive • Different windows for different tissue types allowing the whole range of attenuation to be displayed and improves overall detail.
  • 17. Advantages • Reconstruction possible in any plane desired • Good for surgical planning in complex fractures- 3D reconstruction • Exellent resolution of cortical bone • Better soft tissue attenuation than plain x-ray • CT guided biopsy • CT with contrast Disadvantages • Availability • High resolution dose • Claustrophobia
  • 18. MRI • Newest of the imaging techniques • Does not use ionizing radiation • Principle: body tissues consists of protons/electrons. In a strong uniform field such as MRI scanner, these nuclei align themselves with the main magnetic field. A brief radiofrequency, pulse is applied to alter the motion of the nuclei. When removed, the nuclei realign with the main magnetic field, emitting energy(RF signal).
  • 19. • T2 signal • Time taken for the protons to loose their coherence once radiofrequency turned off • Water rich tissues have longer T2 time as they contain more protons • Hence they release energy for a longer time and give a high signal • T1 signal • Time taken for 63% of the protons to return to the longitudinal spin axis
  • 20. • Repitition time (TR) (msec) • The time between repetition of pulses • T2 images have very high TR time • Otherwise the water dense tissues will not have released enough energy to detect pulses are given frequency though, fat appears white rather than water. • Time to echo (TE) (msec) • Time from when the pulse is stopped to when the signal is measured.
  • 21. • Differential sequences • T1 weighted- short TR (TR<1000 ms), short TE(<60 ms) fat=bright fluid= dark defining anatomy • T2 weighted- long TR (TR>1000ms), long TE (TE>60 sec) Fluid= bright Defining pathology • Proton density (PD)- long TR(TR>1000ms), short TE(TE<60ms) • Part T1, Part T2 • Useful in certain situations e.g. the meniscus
  • 22. • Contrast (Gadolinium) • High net magnetic moment • More strongly affects hydrogen ions in close proximity to the contrast. • Enhances the image and results in high signal on T1 scans as well. • Shows pathologic fluid collections better.
  • 23. • Advantages • No ionizing radiation • High quality image • Can be used with contrast • Abscesses and intra-articular pathology • Disadvantages • Claustrophobia • Noisy • Not tolerated well by children • Availability • Contraindication to MRI e.g. aneurysm clips and pace makers, internal hearing aids, • Metal artifacts: MARS sequence • Over diagnosis of asymptomatic
  • 24. ULTRASOUND • Second most common method of imaging • Relies on high frequency sound waves generated by a transducer containing piezoelectric material • Principle: generated sound waves are reflected by tissue interfaces and, by ascertaining the direction and the time taken for a pulse to return, it is possible to form an image.
  • 25. Acoustic impedance • Impedance between tissues creates echo • Minimal differences between fat and muscle(most waves pass through) • Large difference between air and skin(most waves reflected-use gel) • High impedance=bright • Low impedance= dark
  • 26. Advantages • Non ionizing • Cheap • Portable • Dynamic imaging • Very good for cystic structures • Biopsy, injection, aspiration Disadvantages • Highly operator dependent • Only for superficial structures (cannot penetrate cortical bone) • Limited field of fiew • Poor resolution comparatively
  • 27. BONE SCAN(RADIONUCLIDE IMAGING) • Gamma rays emitted from a radioactive isotope of technetium 99 bound to a phosphate to give a map of blood flow and osteoblastic activity Technetium-99 • Unstable radioisotope • Emits gamma rays • Derived from the decay of molybdenum 99 • Short half life of 6 hours • Excreted via kidney (bladder hydration and
  • 28. Mechanism of action • Technetium-99 is attached to methyl diphosphonate(MDP) when injected iv • The MDP interact with HA crystals in bone- depending on adequate vascularity to the area in question. • Because HA crystals are generated by osteoblasts mineralizing bone it is a direct reflection of osteoblastic activity. • The gamma rays emitted by the T-99 are dected by a gamma camera • A digital image is created giving a map of blood flow and osteoblastic activity
  • 29. Radionuclide imaging…. 3 phases of triple bone scan • Vascular phase (1-2min) • Blood pool phase (3-5 min) • Static phase(4 hrs)
  • 30. Radionuclide imaging… • Single photon emission computed tomography-CT (SPECT-CT) • Gamma camera with CT component on the same scanner • Multi-planar imaging • Increasing resolution, decrease noise and increase localization • Positron emission tomography-CT (PET-CT) • Exploiting increase metabolic rato of tumors i.e glucose consumption • E.g deoxyglucose labelled 18 Fluorine (1/2 life-112 min)
  • 31. Radionuclide imaging… • WBC scan • Labelling patient’s own WBC with radioactive tracer such as indium • Accumulation in the reticuloendothelial system e.g. bone marrow liver and spleen but also areas of active infection • Hybrid PET-MRI • Potential increase bone metastasis assessment and response to treatment
  • 32. Useful for • Tumors (metastatic and primary esp in spine) • Infection-osteomyelitis • Stress fractures • Prosthetic loosening/pain • Paget’s disease Disadvantages • Poor specificity although very sensitive • Radiation dose is fairly high • False negative in areas of low blood supply-e.g avascular bone, lytic tumors
  • 33. DEXA scan • Dual energy x-ray absorbimetry • Utilizes xrays of different energies • Absorbed in different proportions by bone and soft tissues • Used to assess bone mineral density
  • 34. Result interpretation • Units of bone mineral density are g/cm3 • Values are related to the peak bone mass density of a young adult or matched by age • The T score represents comparison with peak BMD of a young adult • The z score represents the age-matched score • Sex and race are matched in both (only difference is age matching in the Z score) • The T score is used to determine whether there is osteoporosis • The Z score is used to assess whether the reduced BMD is related to another cause i.e lower than expected for age
  • 35. WHO criteria for osteoporosis relies on T score • 0 to -1 =normal • -1 to -2.5= osteopenia • <-2.5 = osteoporosis • <-2.5 +fragility fracture=severe osteoporosis Disadvantages • No differentiation between cortical and cancellous density • Falsely high BMD in fractured sclerotic vertebrae and degenerate
  • 36. GENERAL APPLICATION OF IMAGING IN ORTHOPAEDICS General applications • Diagnosis, classification and staging of diseases • Preoperative planning and templating • Intraoperative monitoring • Therapeutic purposes • Monitoring of treatment and healing process
  • 37. Diagnosis • Almost all the modalities are used to make or confirm diagnosis • Plain radiography plays an invaluable role especially in trauma • CT scan usuallu augments plain radiograph, though plays important role in complex trauma • Biopsies can be US, fluoroscopic or CT-guided • DDH, Joint collection by US scanning • Bone scans • Bone densitometry
  • 38. Pre operative planning • Plain radiographs, CT scans with 3D reconstruction and MRI • Plain radiographs used in templating • MRI especially in spine, ligamentous injuries, oncology
  • 39. Intraoperative • Fluoroscopy in fracture fixations • Limb reconstructions • Corrective osteotomies • Spine fixations • Minimally invasive surgeries and closed reductions and fixation
  • 40. Therapeutic/interventional procedures • Arthrography/Diagnostic-therapeutic injections • Facet injections • Discography • Vertebroplasty
  • 41. Monitoring • Fracture healing and status of the implants • Endoprosthesis • Effect of treatment e.g rickets, osteoporosis
  • 42. Risks • Cell death and distorted replication • Cancers-Thyroid (85% of papillary cancers –radiation related), skin and breast cancers • Cataracts Reducing risk(measures) • Justify, optimize (ALARA), limit • PPE • Scatter The annual whole body dose equivalent limit for occupationally exposed persons is 20mSv
  • 43. Take home message • Imaging is paramount in orthopaedic practice • Sound knowledge and broad understanding of radiological techniques as they applied to orthopaedics is paramount for the orthopaedic surgeons
  • 44. References • Ramachandran M, Ramachandran N and Saifuddin A. imaging techniques. • Berquist TH. Imaging of Orthopaedic Fixation Devices and Prostheses. • Rockwood and Green’s Fractures in Adults, 9th edition

Editor's Notes

  1. Characteristic xray generation When a high energy electron collides with an inner shell electron both are ejected from the tungsten atom leaving a ‘Hole’ in the inner layer. This is filled by an outer shell electron with a loss of energy emitted as an x-ray photon. Bremssstrahlung xray generation When an electron passes near the nucleus it is slowed and its path is deflected. Energy lost is emitted as a bremsstrahlung xray photon Aka braking radiation Approx 80% of the population of xrays within the xray beam consists of xray generated in this way
  2. By applying a voltage then reversing the voltage, contraction and expansion of the crystals surface is created This generate a compression wave- the ultrasound wave Pulse echo from tissue return to receiving transducer This again creates a voltage which is used to generate an image Depth of the structures calculated by time taken for the wave to be reflected.
  3. Vascular phase shows arterial flow and hyper perfusion Blood pool phase shows bone and soft tissue hyperemia Static phase shows soft tissue activity has cleared leaving only bone activity