1. Cefdinir microspheres were formulated using an emulsion solvent evaporation method to improve the drug's therapeutic efficacy by increasing its biological half-life and providing controlled release. 2. Microspheres of different drug to polymer ratios were produced and evaluated for particle size, drug loading, and in vitro drug release. Higher polymer ratios led to larger particle sizes and increased drug loading. 3. In vitro drug release studies showed all microsphere formulations provided sustained release over 12-20 hours, with an initial burst release of 60% of the drug within 5-10 hours, followed by slow release of the remaining drug over the study period. This biphasic release profile could achieve therapeutic drug levels while maintaining