1. Transdermal Drug Delivery

15. Types of Transdermal Systems Transdermal systems are used for delivery of analgesics (fentanyl), hormone replacement therapies (estradiol and testosterone) and medications for angina (nitroglycerin), hypertension (clonidine), and motion sickness (scopolamine). Transdermal systems that deliver nicotine for use in smoking cessation are also available. In Japan and in parts of Europe, systems that incorporate antiinflammatory drugs (flurbiprofen and ketaprofen) and monoamine oxidase inhibitors such as selegiline have also been introduced. In this section, a review of a selected group of systems is provided with an emphasis on product characteristics and the clinical performance measures of safety, efficacy, reliability, and acceptability of drug treatment

21. Fig. System Controlled Drug Delivery System

24. Table 1 Transdermal Controlled-Release Products and Devices Drug Trade Name Type of Devices Indication Scopolamine Transderm-Scop Reservoir Motion sickness Nitroglycerine Transderm-Nitro Reservoir Angina Nitro-Dur Monolithic Nitrodisc Monolithic Estradiol Estraderm Reservoir and ethanol enhancer Hormone treatment

25. Table 2 Transdermal Products under Development Drug Trade name Producer-Marketer Minocycline Sunstar American Cyanamide, Takeda Estradiol+Norethisterone Estracombi TIS Ciba-Geigy, Alza DHEA Pharmedic Fentanyl Triamcinolone acetonide Whitby Pharm.