Hormones play an important role in certain cancers like breast, prostate, and ovarian cancer. Hormones stimulate the growth of cancerous cells in hormone-dependent cancers. Risk factors for breast cancer include factors affecting hormone levels like early menarche, late menopause, hormone replacement therapy, and oral contraceptive use. Prostate cancer risk is influenced by ethnicity and androgen receptor genes. Hormonal therapies target hormone levels and receptors to slow cancer growth by using medications like anti-androgens and GnRH agonists.

1. HORMONES AND CANCER HORMONES AND CANCER Richin john koshy

2. OVERVIEW:HORMONES HORMONE DEPENDENT CANCER RISK FACTORS CAUSING CANCER PATHOPHYSIOLOGY THERAPEUTIC MEDICATIONS CONCLUSION

3. Hormones are peptide or a steroid which is produced by a tissue and conveyed to the bloodstream to the target organs for maturation Hormones are involved in growth and development of an individual

4. HORMONE DEPENDENT CANCERS: Hormones share a strong bond in cancer and its progression and the role in which hormones play in cancer are seen in breast ,prostate and ovaries

5. RISK FACTORS : BREAST CANCER Null ParityEarly Menarche Late MenopauseHormone Replacement TheraphyHigh Fat Diet Oral Contraceptive Pills ? DEBATE

6. RISK FACTORS:PROSTATE CANCEREthnic groupAndrogen receptor

7. PATHOPHYSIOLOGY

10. ANTI ANDROGENS :Bicalutamide and Nilutamide which block the binding of androgen to receptors are commonly used as a hormonal therapy GNRH AGONIST :Leuprolide acetate or Goserelin acetate can be given which eventually leads to chemical castration

12. Testosterone hormone stimulates the growth of cancerous cells and it is the fuel for cancerous growth

13. Luteinising hormone from the anterior pituitary stimulates the release of testosterone from the testes and hormonal therapy in prostate cancer is androgen deprivation which can be accomplished surgically by orchidectomy (castration ) as the body's source of testosterone is removed

14. Conclusion Breast and Prostate tumours have a common feature in that at some stage in their evolution they were hormone dependent cancers, and therefore hormone therapy is an intuitively obvious therapeutic approach

15. RefrencesRisbridger ,G.P et al.Breast and prostate cancer more similiar than diffrent .Nature (2010) Ricke, W. A. et al. Prostatic hormonal carcinogenesis ismediated by in situ estrogen production and estrogen trial. J. Urol. 176, 965–970 (2006)Ma, X. J., Dahiya, S., Richardson, E., Erlander, M. &Sgroi, D. C. Gene expression profiling of the tumor microenvironment during breast cancer progression.BreastCancer Res. 11, 7 (2009).