Breast Cancer hormone therapy

1. Breast Cancer
Hormone therapy
1
Brian Lin

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8. Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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9. Cancer Arises From
DNA Mutations in Cells
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10. Cancer Arises From
DNA Mutations in Cells
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13. Estrogen Effect
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Beneficial
effects
Breast
Programs milk
production
Liver and
heart
Controls
cholesterol
Harmful
effects
Breast
Increases
cancer risk

14. Estrogen Effect
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Liver and
heart
Controls
cholesterol
Uterus
Prepares
for fetus
Bone
Preserves
strength
Uterus
Increases
cancer risk
Beneficial
effects
Harmful
effects

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Hypothalamus(下視丘)
Gonadotropins (促性腺激素)
-FSH (濾泡刺激素)
-LH (黃體生成素)
Ovary(卵巢)
Estrogens (雌激素)
Progesterone (黃體激素)
Prolactin
Growth Hormone
Pituitary gland
Adrenal gland
(腎上腺)
Progesterone
(黃體激素)
Androgens
(雄性素)
Estrogens
(雌激素)
Corticosteroids
(皮質固醇)
Premenopausal
Adrenocorticotropic
hormone (ACTH： 促
腎上腺皮質素)
Estrogen production

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Hypothalamus(下視丘)
Gonadotropins (促性腺激素)
-FSH (濾泡刺激素)
-LH (黃體生成素)
Ovary(卵巢)
Estrogens (雌激素)
Progesterone (黃體激素)
Prolactin
Growth Hormone
Pituitary gland
Adrenal gland
(腎上腺)
Progesterone
(黃體激素)
Androgens
(雄性素)
Estrogens
(雌激素)
Corticosteroids
(皮質固醇)
Premenopausal
Adrenocorticotropic
hormone (ACTH： 促
腎上腺皮質素)
Estrogen production

17. Estrogen-Induced Proliferation and
Spontaneous New Mutations
17
ArtworkbyJeanneKelly.©2010.
Estrogen stimulation
Normal breast cell
Mistake in DNA duplication
Increased proliferation

18. Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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19. Surgery

20. Surgery Chemotherapy

21. Surgery
Radiation therapy
Chemotherapy

22. Surgery
Radiation therapy
Chemotherapy
Hormone therapy

23. Surgery
Radiation therapy
Chemotherapy
Hormone therapy
Tageted therapy

24. Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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25. • 補充女性荷爾蒙
• 減少停經症候群發生
Postmenopausal
• 使用抗荷爾蒙藥物
• 減少乳癌復發
Early Stage
Breast Cancer
• 使用抗荷爾蒙藥物
• 延緩乳癌疾病的惡化
Metastatic
Breast Cancer
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60-66%
ER+ or PR+
21-25%
HER2+
13-15%
ER-/PR/HER2-
可用賀爾蒙療法
可用標靶治療

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Estrogen receptor antagonist 抗雌性激素
• 與雌性激素競爭受體，以阻斷雌性激素作用
• Tamoxifen
Aromatase Inhibitor 芳香環轉化酵素抑制劑
• 阻斷雌性激素的生成
• Anastrozole, Letrozole, Exemestane
GnRH agonist 類性腺激素釋放素
• 促黃體激素釋放荷爾蒙致效劑(LH-RH致效劑)
• Goserelin (Zoladex)

28. Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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Estrogen
(雌性激素)
FSH, LH
(促雌性素)

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Tamoxifen
Zoladex
Estrogen
(雌性激素)
FSH, LH
(促雌性素)

31. Hormonal Therapy - Tamoxifen
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Estrogen
Progestrone
Tamoxifen

32. Hormonal Therapy - Tamoxifen
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Estrogen
Progestrone
Tamoxifen

33. Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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Adrenal gland
(腎上腺)
Androgens
(雄性素)
Aromatase
芳香環轉化酶
Estrogen
(雌性激素)

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Adrenal gland
(腎上腺)
Androgens
(雄性素)
Aromatase
芳香環轉化酶
Estrogen
(雌性激素)
Aromatase
Inhibitor
Tamoxifen

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乳癌診斷及治療請洽專科醫師