This document discusses the classification and management of migraine headaches. It begins by outlining the International Classification of Headache Disorders criteria for classifying different types of migraines, including migraine without aura, migraine with aura, hemiplegic migraine, and chronic migraine. It then discusses the epidemiology, pathophysiology involving CGRP and other factors, and diagnostic criteria for some of the main migraine subtypes. The remainder of the document focuses on guidelines for managing acute migraines, preventing migraines, and treating refractory or chronic migraines, including in special populations like pregnancy and children. Treatment options discussed include triptans, CGRP antagonists, topiramate, valproate, and neurom
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This talk summarizes the definition, diagnosis and management strategies of migraine. It will be useful for general public as well as healthcare professionals.
This is more of a summary of recent evidence available on migraine management. It is easy to read and understand. Please post your queries and comments.
CONCEPT OF NODOPATHIES AND PARANODOPATHIES.pptxNeurologyKota
emergence of autoimmune neuropathies and role of nodal and paranodal regions in their pathophysiology.
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have clinical phenotype similar common inflammatory neuropathies like Guillain Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
they respond poorly to conventional first line immunotherapies like IVIG
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This presentation contains information about the various Entrapment syndromes of Lower limb in descending order of topography. It also contains information about etiology, clinical features and management of each of these entrapment syndromes with special emphasis on electrodiagnostic confirmation.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Stay informed, stay safe, and get your flu shot today!
4. The term migraine derives from the ancient Greek word, hemikranios, which means “half head,”
underscoring the unilateral distribution of head pain that is present in about 60%–75% of people
with migraine.
5. MIGRAINE
ICHD-3 Classification
1.1 Migraine without aura
1.2 Migraine with aura
1.2.1 Migraine with typical aura
1.2.1.1 Typical aura with headache
1.2.1.2 Typical aura without headache
1.2.2 Migraine with brainstem aura
1.2.3 Hemiplegic migraine
1.2.3.1 Familial hemiplegic migraine
1.2.3.1.1 Familial hemiplegic migraine type 1
1.2.3.1.2 Familial hemiplegic migraine type 2
1.2.3.1.3 Familial hemiplegic migraine type 3
1.2.3.1.4 Familial hemiplegic migraine, other
loci
1.2.3.2 Sporadic hemiplegic migraine
1.2.4 Retinal migraine
1.3 Chronic migraine
1.4 Complications of migraine
1.4.1 Status migrainosus
1.4.2 Persistent aura without infarction
1.4.3 Migrainous infarction
1.4.4 Migraine aura-triggered seizure
1.5 Probable migraine
1.5.1 Probable migraine without aura
1.5.2 Probable migraine with aura
1.6 Episodic syndromes that may be associated
with migraine
1.6.1 Recurrent gastrointestinal disturbance
1.6.1.1 Cyclical vomiting syndrome
1.6.1.2 Abdominal migraine
1.6.2 Benign paroxysmal vertigo
1.6.3 Benign paroxysmal torticollis
6. EPIDEMIOLOGY
• Migraine one-year prevalence 12% in the general population, 18% women, 6% men.
• Migraine afflicts prepubescent boys and girls with a similar frequency.
• Peak migraine prevalence for both sexes occurs in fourth decade approximately 24% of women and
7% of men have migraine
Lipton, RB, Bigal, ME, Diamond, M, et al. Migraine prevalence, disease burden, and the need for preventative therapy. Neurology
2007; 68:343
7. MIGRAINE WITHOUT AURA
Previously used terms:
•Common migraine; hemicrania simplex.
Description:
• Recurrent headache disorder manifesting in attacks
• Lasting 4-72 hours.
• Typical characteristics of the headache are unilateral location, pulsating quality, moderate or
severe intensity, aggravation by routine physical activity and association with nausea and/or
photophobia and phonophobia
8. DIAGNOSTIC CRITERIA
• A. At least five attacks fulfilling criteria B–D
• B. Headache attacks lasting 4-72 hours (untreated or unsuccessfully treated)
• C. Headache has at least two of the following four characteristics:
1. unilateral location
2. pulsating quality
3. moderate or severe pain intensity
4. aggravation by or causing avoidance of routine physical activity (e.g. walking or climbing stairs)
• D. During headache at least one of the following:
1. nausea and/or vomiting
2. photophobia and phonophobia
• E. Not better accounted for by another ICHD-3 diagnosis.
9. MIGRAINE WITH AURA
Previously used terms:
•Classic or classical migraine; complicated migraine.
Description:
• Recurrent attacks, lasting minutes, of unilateral fully reversible visual, sensory or other
central nervous system symptoms that usually develop gradually and are usually followed by
headache and associated migraine symptoms.
10. DIAGNOSTIC CRITERIA
• A. At least two attacks fulfilling criteria B and C
• B. One or more of the following fully reversible aura symptoms:
1. visual
2. sensory
3. speech and/or language
4. motor
5. brainstem
6. retinal
• C. At least two of the following four characteristics:
1. at least one aura symptom spreads gradually over 5 minutes, and/or two or more symptoms occur in
succession
2. each individual aura symptom lasts 5-60minutes
3. at least one aura symptom is unilateral
4. aura is accompanied, or followed within 60 minutes, by headache
• D. Not better accounted for by another ICHD-3 diagnosis, and transient ischemic attack has been
excluded.
11. Migraine with brainstem aura
Diagnostic criteria:
• A. At least two attacks fulfilling criteria B-D
• B. Aura consisting of visual, sensory and/or speech/ language symptoms, each fully reversible, but
no motor or retinal symptoms
• C. At least two of the following brainstem symptoms:
1. dysarthria
2. vertigo
3. tinnitus
4. hypacusis
5. diplopia
6. ataxia
7. decreased level of consciousness
12. • D. At least two of the following four characteristics:
1. at least one aura symptom spreads gradually over 5 minutes, and/or two or more symptoms occur in
succession
2. each individual aura symptom lasts 5-60 minutes
3. at least one aura symptom is unilateral
4. aura is accompanied, or followed within 60 minutes, by headache
• E. Not better accounted for by another ICHD-3 diagnosis, and transient ischaemic attack has been excluded.
13. Hemiplegic migraine
Diagnostic criteria:
• A. At least two attacks fulfilling criteria B and C
• B. Aura consisting of both of the following:
1. fully reversible motor weakness
2.fully reversible visual, sensory and/or speech/ language symptoms
• C. At least two of the following four characteristics:
1. at least one aura symptom spreads gradually over 5 minutes, and/or two or more symptoms occur in
succession
2.each individual non-motor aura symptom lasts 5–60 minutes, and motor symptoms last <72 hours
3.at least one aura symptom is unilateral
4. the aura is accompanied, or followed within 60 minutes, by headache
• D. Not better accounted for by another ICHD-3 diagnosis, and transient ischaemic attack and stroke
have been excluded.
16. A dysfunction of
neuromodulatory
structures locus
coeruleus or
periaqueductal grey
matter and hypothalamus
CGRP
5-HT1B/1D
receptors,
Prostaglandins
Leukotrienes
Integrated Neurovascular Hypothesis
26. Childhood migraine
• Headaches during childhood (7.7%), increase in frequency during adolescence
• Acetaminophen and NSAIDs, ibuprofen best.
• Three Triptans are approved (USFDA)for use in this population:
almotriptan -12 to 17 yrs
Rizatriptan - 6 to 17 yrs
sumatriptan with naproxen -12 yrs and older
• Prohylactic Topiramate Valproate and Cyprohepatidine are considered better than Amitryptiline and
Propranolol
27. Menstrual migraine
• Menstrual migraine attack 2 day before and up to 3 days after the onset of menses, not at any
other time.
• Short term prophylaxis with Triptans (Sumatriptan 25 BD) or Naproxen 500 BD
• Hormonal therapy (OCPs without missing)
– Transdermal estradiol (1 x 100 ug days -3--+2)
– Combined oral contraceptive or transdermal patch
– Percutaneous estradiol (1.5 mg daily days -3 to +6)
28. Hormone and Migraine
• Systemic Review and meta-analysis done by
Noori-Zadeh et al suggest hyperprolectinemia in
Migraineurs as compare to control group
• Testosterone and androgen levels found to be low in male migraineurs with low Tr/Estradiol level
• Estrogen withdrawal and low progesterone, FSH and LH, B-hcG level associated with migraine
• TSH levels has no implications on migraine attack frequency.
Neurological Sciences; Ali Noori-Zadeh1 & Morvarid Karamkhani2 & Ali Seidkhani-Nahal3 & Afra Khosravi4 & Shahram Darabi5 https://doi.org/10.1007/s10072-019-04035-7
29. PREGNANCY AND LACTATION
• Acetaminophen (650 -1000mg) and metoclopramide(10mg) are the only treatments for migraine
that are considered safe in pregnancy.
• 2nd line options are safest in the second trimester before 20 weeks – NSAIDS, after that concerns
about prenatal constriction of the ductus arteriosus, persistent pulmonary hypertension of the
newborn, oligohydramnios
• Triptan 2nd & 3rd trimesters increased risk of uterine atony, blood loss during labor.
However sumatriptan came out to be reassuring in pregnancy registry
• Medication safe during lactation acetaminophen,ibuprofen, metoclopramide, prochlorperazine,
diphenhydramine, and sumatriptan.
30. Emergency setting - Migraine
Reasonable options –
• Sumatriptan 6 mg subcutaneous injection
• Antiemetics/Dopamine receptor blockers
Metoclopramide 10 mg intravenous (IV)
Prochlorperazine 10 mg IV or intramuscular (IM)
Chlorpromazine 0.1 mg/kg IV
• Dihydroergotamine (DHE 45) 1 mg IV combined with metoclopramide 10 mg IV
• Ketorolac 30 mg IV or 60 mg IM
Headache. 2012 Jan;52(1):114-28. Epub 2011 Dec 28.
adjunct use
of diphenhydrami
ne (12.5 to 25 mg
IV every hour up
to two doses) to
prevent akathisia
and other dystonic
reactions
31. Treatment of Status migraine
Defined as headache that last for more than 72 hours whether it has been treated or not
Combination of I.V. fluids and ketorolac or DHE or valproiate and metocloperamide
Single dose of parenteral dexamethasone (10 to 24 mg) reduce risk of early headache recurrence in the
emergency department.
Intravenous methylprednisolone in a single dose can be utilized to break long-lasting migraine attacks.
Gallagher RM. Emergency treatment of intractable migraine. Headache 1986;26:74–75
32. Refractory Migraine
• Parenteral ergotamine refractory migraine. should be avoided for 24 hours after administration of
a triptan.
• I.V. MgSO4 (1 to 2 g) effective alternative treatment for migraine with aura.
• I.V. valproate is commonly used, but the evidence contradictory
• iv metoclopramide, Prochlorperazine(level b)
• Corticosteroids-dexamethasone- should be offered to these patients to prevent recurrence of
headache (Should offer—Level B)
33. COVID 19 and Migraine
• Headache one of the symptoms of COVID-19 infection(8%)
• Migraine patients see a spike in their attacks, reason abundance of migraine triggers.
• Current guidelines uses of nonsteroidal anti-inflammatory drugs (NSAIDs), triptans and
narcoleptics are safe for the acute treatment of migraine attacks. Stop ACEI, ARB weighing risk
benefit.
• Doctors, nurses and other health care professionals higher migraine risks than the general
population Working for grueling shifts of 6–8 h wearing personal protective equipment (PPE), it was
found that 81% of HCW developed de novo PPE associated headaches
• Sanitizers and soaps with strong odors should be avoided
34. When to start Preventive treatment
1. Recurring migraine that significantly interferes with the patient’s daily routine despite
acute treatment.
2. Failure of, contraindication to, or intolerable side effects to acute medications.
3. Acute medication overuse or the risk of developing acute medication overuse.
4. Special circumstances, such as hemiplegic migraine or migraine attacks with a risk of
permanent neurologic injury.
5. High-frequency episodic migraine or a pattern of increasing migraine attacks over time.
6. Patient preference, or patient desire to have as few acute attacks as possible.
35. Preventive medications for treatment of migraine
Loder E, Burch R, Rizzoli P. The 2012 AHS/AAN guidelines for prevention of episodic migraine: a summary and comparison with
other recent clinical practice guidelines. Headache 2012; 52:930
36.
37. Botulinum Toxin for the Treatment of Chronic
Migraine
• Botulinum toxin type A inhibit the release of glutamate and calcitonin gene-related peptide ,
• Reduce the activity of central nociceptive neurons.
• FDA approved dosage is 155 Units distributed in 31 sites as in the PREEMPT trials
• Onabotulinumtoxin type A reaches its clinical effect at 7–10 days and plateaus at 3 weeks
38.
39.
40. Adherence, persistence to medications,Duration of
treatment
• Low adherence and persistence due to side effects and poor efficacy.(29% at 6 months and 20% at 12
months).
• Educate patient on long duration of treatment, need for adherence and persistence and expected
outcomes.
• Outcome: might not be complete cessation of headaches. >50%reduction can be reasonable.
• Lowering of dose be individualized to minimize side effects.
• Effective preventive therapy: 3-6 months before taper/stop.
• Don't discontinue any medication before trial with desired dose is given for at least 2-3 months.
41. MAbs Phase 3 Trials for Episodic(EM) and
Chronic(CM) Prophylaxis
42. M Ashina. N Engl J Med 2020;383:1866-1876.
Response Rates in Phase 3 Randomized Trials of
Monoclonal Antibodies against CGRP or Its Receptor for
Prevention of Episodic Migraine.
43. Triptans: : Level A; AHS
• More effective for moderate/severe HA than NSAIDs.
• Oral dose: almo 12.5, ele 20, nara 2.5,riza 5,suma 50, zolmi 2.5
• 2 hr relief: 42-76% (placebo 27%), half even had relief at 24 hr.
• Triptan combination even better (sumatriptan 85 and acetaminophen/napro 500 (80%,62%).
• C/I: history of stroke, MI, CAD, HM, migraine with BA, uncontrolled HTN, PAD.
• Avoid riza, zolmi, suma in 2wks of MAOI use (serotonin syndrome) New formulations: intranasal
suma , zolmitriptan spray.
44. Two randomized, double-blind, single-attack, parallel-group studies conducted at 118 clinical centers
in the US.
The studies included 1,461 (study 1) and 1,495 (study 2) individuals with migraine.
Sumatriptan (85 mg) and naproxen (500 mg) fixed-dose tablet for acute migraine attack superior
to monotherapy with either sumatriptan or naproxen, and was well tolerated
45. M Ashina. N Engl J Med 2020;383:1866-1876.
Freedom from Pain at 2 Hours in Randomized Clinical Trials of Treatments for
Migraine.
46. Nasal and Parentral route
• The nasal sprays result in substantial blood levels within 30–60 min.
• Their reported efficacy is only approximately 50–60%.
• Sumatriptan, 6 mg subcutaneously, is effective in ~70–80% of patients
47. Ditans, New 5-HT1F Agonist Acute Migraine
Medication
• Why new serotonin agonist?•
Limitations of triptans:
not all patients respond, not all patients tolerate
contraindicated in cardiovascular or cerebrovascular disease (5HT1B receptor stimulation).
• Ditans: Most specific- on 5-HT1F receptor (Lasmiditan- 200 and 100 mg).
• SAMURAI, SPARTAN trials- finished. GLADIATOR- ongoing- interim analyses- effective.
• US FDA approved: Oct 2019
• 2 hour pain freedom is about 30%.
• Adverse effects: moderate dizziness and somnolence at 10-15%, less than triptans. Adverse events
drug may cause driving impairment, and patients should not drive a motor vehicle, operate
machinery, or engage in potentially hazardous activities for at least eight hours after each dose of
lasmiditan
• Do not cause vasoconstriction (caused by 5-HT1B agonists), so safe in vascular disease.
Kuca B, Silberstein SD, Wietecha L, et al. Las miditan is an effective acute treatment for migraine: a phase 3 randomized study. Neurology 2018;91:e2222-e2232.Goadsby
PJ, Wietecha LA, Dennehy EB, et al. Phase 3 randomized, placebo controlled, double-blind study of lasmiditan for acute treatment of migraine. Brain (in press 2019).
50. Greater occipital nerve block
Friedman BW, West J, Vinson DR, et al. Current management of migraine in US emergency departments: an analysis of the
National Hospital Ambulatory Medical Care Survey. Cephalalgia 2015;35(4):301–9
51. Neuromodulation Devices
• The Transcutaneous Supraorbital Neurostimulator :
• This FDA-approved (Cefaly Device)
• Preventative and acute treatment of migraine.
• Preventative treatment with for 20 minutes daily.
• Acute treatment, with a different setting of the device, lasts one hour.
• Device cost - $540.
• Electrodes needs to be replaced about every 3 months for $25.
52. • Non-Invasive Vagus Nerve Stimulator:
• GammaCore
• Used for acute attacks
• the cost of one month of use of gammaCore is currently $575.
53. • Transcranial Magnetic Stimulator:
• acute and preventative treatment of migraine.
• The preventive dose is 4 pulses of the magnet twice daily, with as needed extra pulses for acute
treatment to a maximum of 17 pulses per day
54. Non-Pharmacological
• Behavioural therapies
• Aim to reduce headache-related disability, quality of life, and psychological comorbidity.
• Indicated in patients with significantly impact of migraine
if non pharmacologic therapy preferred due to side effects
if patient behaviours and stress triggers for migraine attacks
Types: relaxation training, thermal/EMG biofeedback, cognitive-behavioral therapy. mindfulness
Level A recommendations by AAN.
55. Acute non pharmacological treatment
• Nerve blocks: No high evidence: supraorbital/troch/occipital nerve block but many experts use in
severe cases.
• Neurostimulation: Supraorbital nerve TENS: open-label trial: 2 hr pain relief 52.8%.However 1/3
required rescue medication.
• Non invasive VNS had 2 hr pain relief was 47%
• Single-pulse TMS: migraine with aura. 24hr relief 30% vs 15 placebo.
56. Role of spectacles in
migraine prevention.
• MigraLens are spectacle lenses with a pleasant green hue.
• Specifically absorb the wavelengths that cause migraine symptoms and migraine sensitivity.
• A clinical study shows participants who wore average of 6.2 to 1.6 migraine attacks per month—
that’s a 74% reduction in attacks!
57. Ongoing research
Spiegelmers
What is Spiegelmer?- a chemically synthesized mirrorimage oligonucleotide that can bind its target
with high specificity, comparable to antibodies.
CGRP-targeted Spiegelmers using CGRP-neutralizing L-aptamers- have been tested.
NOX-C89 and NOX-L41 can both bind CGRP.
NOX-C89- studies in rats:- Binds also to amylin- development halted.
NOX-L41- In vivo (rats)- inhibit plasma protein extravasation in the rat dura mater for 18hrs.
• Anti-pituitary adenylate cyclase-activating polypeptide (PACAP) mAbs
AMD-301- targets the PAC1 receptor.
undergone a phase II clinical trial.
Hoehlig K, Johnson KW, Pryazhnikov E, et al. A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation. Br, Pharmacol. 2015;172(12):3086-3098. Do, T.P., Guo, S.
& Ashina, M. Therapeutic novelties in migraine: new drugs, new hope?. J Headache Pain 20, 37 (2019).
58. Points to ponder
• Our understanding of the mechanisms underlying migraine has evolved during the past decade, with
pathogenesis of migraine and the development of mechanism-based therapies.
• But uncertainties exact origin of migraine pain, mechanism underlying the paroxysmal nature and
features of migraine, exact site and mode of action of migraine-specific medications.
• An effort is needed to find new drug targets and develop biomarkers that can predict which patients
will have a response to each targeted therapy
60. References
• Continuum headache november 2018.
• American Academy of Family Physicians 2018 guideline
• The American Headache Society 2016 guideline.
• Neurology clinic 2019
• NEJM December 2020 Migraine review
• Seminars in neurology February 2021
• Annals of India supplement April 2020
• www.uptodate.com
Editor's Notes
3 is to 1 ratio
Theories on the pathogenesis of migraine include:
• The vascular theory
• The cortical spreading depression theory
• The neurovascular hypothesis
• The serotonergic abnormalities hypothesis
• The integrated hypothesis.
The prodrome phase consists vegetative or affective symptoms as much as 48 hours prior to the onset of a migraine attack.
The aura phase consists of focal neurological symptoms that persist up to one hour. Symptoms may include visual, sensory, or language disturbance as well as symptoms localizing to the brainstem.
Within an hour of resolution of the aura symptoms, the typical migraine headache usually appears.
resolution phase often characterized by deep sleep
Figure 4. Proposed Treatment Algorithm for the Clinical Management of Migraine. Nonsteroidal antiinflammatory drugs (NSAIDs) should be considered first-line medications for the treatment of migraine attacks. Patients in whom NSAIDs provide no or inadequate pain relief should be offered an oral triptan. If an oral triptan provides no pain relief, other triptans should be offered. Combination therapy with naproxen sodium should be offered to patients who have inadequate pain relief with triptan. Ideally, clinicians should first offer subcutaneous sumatriptan when a patient has had inadequate pain relief with all oral triptans. However, subcutaneous sumatriptan may be tried at an earlier stage if oral triptans cannot be ingested because of vomiting or if headache intensity peaks rapidly. Ditans and gepants may be considered for patients in whom NSAIDs and all available triptans are ineffective, have unacceptable side-effect profiles, or are contraindicated. The decision about when to substitute a triptan with a gepant or ditan may differ among countries and should be made in accordance with local practice guidelines. Antiemetic agents may be offered as adjunctive therapy in patients with attacks accompanied by nausea or vomiting. Initiation of preventive treatment depends on local practice guidelines but should, in general, be considered for patients who have at least 2 migraine days per month and are adversely affected despite therapy.
Scoring is as follows: 0 = very poor treatment efficacy; 1–5 = poor treatment efficacy; 6–7 = moderate treatment efficacy; 8 = maximum
treatment efficacy.
Treatment choice ibuprofen
Melatonin 0.5 mg to 3mg
Amitrypta – 0.25 – 0.5mg/kg
Propano – 1 to 3 mg/kg
CHAMP trial
PedMIDAS trial
Butterbur Butterbur is a plant extract with spasmolytic and analgesic effects
Avoid triptans and estrogen and ergot in Migraine with aura
Menstrual migraine are without aura
Pure menstrual migraine (PMM),
Menstrual-related migraine
Estrogen withdrawal before menstruation is a trigger for migraine
LUMINA registry for assesment of female and male sex hormone level in migraineurs with control (436 pts )
Acetaminophen and codeine 30 mg
Butalbital-acetaminophen-caffeine 40 -50 >200
Butalbital should be limited to only four to five days per month and codeine to no more than nine days per month to avoid development of medication overuse headache.
.1)In these cases, parenteral NSAIDs and/or antiemetics are preferred.
Magnesium-
Reduces neuronal hyperexcitability
Migraine is a chronic neurological disorder which is the
6th commonest and 2nd most disabling medical condition in the
world.
As per the epidemiological data from two parts of the
country, namely Karnataka[2] and NCT of Delhi (unpublished
data), a 1‑year prevalence is more than 25%.
Start the chosen drug at a low dose and increase it slowly until therapeutic
effects develop
Consider comorbidity and coexistent illnesses in drug choice
Give each treatment an adequate trial
Set realistic goals. Success is defined as a 50% reduction in attack frequency or headache days, a significant decrease in attack duration, or an improved response to acute medication.
Topiramate was approved by the FDA for migraine prevention in children
12 to 17 years old while the CHAMP trial was ongoing, and it remains the only medication
approved by the FDA for migraine prevention in adolescents
Mitochondria enzyme
4)parthenolide.
Butterbur Butterbur is a plant extract with spasmolytic and analgesic effects- 150mg
Vitamin D
Tonabersat, a modulator of neuronal gap junctions that inhibits CSD
Riboflavin-
Alters neuronal oxidative metabolism
2)decreased expression of immediate early genes (c-Fos) after nociceptor stimulation.
4) duration of benefit is 12–16 weeks
Migraine prevention studies:
Reduction in mean monthly migraine days (MMD).
50% reduction in monthly migraine days (MMD).
Mean change in headache hours from baseline.
Reduced use of acute medication.
Improvement in Migraine Disability Assessment scores.
2-hour freedom from the most bothersome symptom (MBS)- nausea,photophobia, or phonophobia.
Figure 3. Response Rates in Phase 3 Randomized Trials of Monoclonal Antibodies against CGRP or Its Receptor for Prevention of Episodic Migraine. The response rate was defined as the proportion of patients with at least a 50% reduction in the number of migraine days per month from baseline to the time of assessment. The time of assessment for each trial was as follows: PROMISE-1 (Prevention of Migraine via Intravenous Eptinezumab Safety and Efficacy 1),70 weeks 1 through 12; STRIVE,64 weeks 13 through 24; ARISE,72 weeks 9 through 12; the fremanezumab trial,66 weeks 1 through 12; and EVOLVE-1 (Evaluation of LY2951742 in the Prevention of Episodic Migraine 1)68 and EVOLVE-2,73 months 1 through 6. In EVOLVE-1 and EVOLVE-2, patients received a loading dose of 240 mg of galcanezumab, followed by 120 mg per month.
Figure 2. Freedom from Pain at 2 Hours in Randomized Clinical Trials of Treatments for Migraine. Freedom from pain 2 hours after treatment and before the use of rescue medication is the primary measure of efficacy that has been used in controlled trials of treatments for migraine attacks in adults. Panel A shows the proportion of patients who were free of pain 2 hours after treatment with oral acetylsalicylic acid, oral diclofenac, or oral ibuprofen, as determined in meta-analyses by the Cochrane Collaboration.46-48 Panel B shows the proportion of patients who were free of pain 2 hours after treatment with oral sumatriptan, subcutaneous sumatriptan, or the combination of oral sumatriptan and naproxen sodium, as determined in meta-analyses by the Cochrane Collaboration.49,50 Panel C shows the proportion of patients who were free of pain 2 hours after treatment with doses of lasmiditan, rimegepant, or ubrogepant approved by the Food and Drug Administration, as determined in phase 3 trials.51-54
Ubrogepant received US Food and Drug Administration (FDA) approval for the treatment of acute migraine in adults in December 2019 [116], and rimegepant received similar FDA approval in February 2020
medial landmark is the occipital protuberance.
The lateral landmark is the mastoid process. Using these landmarks to form a line,
the injector identifies the correct location, which is one-third of the distance from the occipital
protuberance along this line
1) uses electrodes for stimulation. Patients place the electrodes on their forehead, connect the device to the electrodes,
The patient applies gel on the device, places it on the side of the neck, then turns the device on. It is programmed in cycles to stimulate for two minutes, and one treatment consists of three cycles.
Relaxation techniques are thus thought not only to relax muscle
tension overall but also to decrease the sympathetic nervous system’s response to Stress.
BF is a self-regulatory technique whose purpose is to enable patients to gain voluntary control of varied physiologic functions
CBT focuses on cognitive and behavioral accompaniments of migraine (eg, anxiety, depression, sleep disorders, migraine, pain)
MF designed to promote nonjudgmental acceptance and awareness of oneself, one’s present situation, and pain
PACAP – member of VasoInstes Peptide family
PAC1 receptor present on vascular smooth muscle