Head lice are parasitic insects that live on the human scalp and feed on blood. They can cause itching and difficulty sleeping. Signs of an infestation include tickling or itching of the scalp and sores from scratching. Diagnosis involves finding live lice or nits firmly attached to hair. Treatment requires using an over-the-counter or prescription medication and combing out lice and nits. Head lice spread mainly by direct head-to-head contact and can affect anyone but are most common in young children.