Lyme disease is caused by the bacterium Borrelia burgdorferi and transmitted through infected tick bites, with symptoms often mimicking other diseases, complicating diagnosis. An estimated 300,000 cases are diagnosed each year in the U.S., with early treatment using antibiotics typically leading to recovery; however, lingering symptoms can persist in some patients. Prevention strategies include avoiding tick habitats, wearing protective clothing, using repellents, and checking for ticks after outdoor activities.