This document compares three switching methods for an asymmetric cascaded H-bridge multilevel inverter: selective harmonic elimination (SHE), nearest level control (NLC), and multi-carrier pulse width modulation (PWM). SHE and NLC aim to minimize total harmonic distortion but are offline methods not suitable for closed-loop systems. Multi-carrier PWM provides appropriate harmonic performance while being an online method. Equations are presented for generating PWM signals to control the switches in each cell based on multiple carrier waves to synthesize a high number of voltage levels from asymmetric DC input voltages. Simulation results show multi-carrier PWM has advantages over SHE and NLC for use in an asymmetric multilevel inverter system.