This document discusses Ghanavati Kalpana, a type of solidified extract tablet used in Ayurvedic medicine. It begins by introducing Bhaishajya Kalpana, the branch of Ayurveda dealing with dosage forms. It then defines Ghanavati as an extractive tablet made by evaporating water from herbal solutions to produce a thick sticky mass that is rolled into pills. The document aims to establish Ghanavati as a superior dosage form by comparing it to powder and tablet forms. It finds Ghanavati more potent due to its smaller particle size and higher concentration of active phyto-constituents. It concludes Ghanavati is superior to powders and tablets

1. Presenter:
Mangesh Dhote
PG Scholar, Dept of Rasashastra &
Bhashajya kalpana
Mahatma Gandhi Ayurveda College
& Research Center
Guided by:
Dr. Bharat Rathi
Professor ,
Dr. Dhiraj Singh Rajput
Asso. Professor
Dept. of Rasashastra & Bhashajya
kalpana
Datta Meghe Institute of Medical Sciences
(Deemed University)
Mahatma Gandhi Ayurved College, Hospital & Research
Centre, Salod (Hirapur), Wardha.

2. Content
 Introduction
 Ghanavati Kalpana
 Aim and objectives
 Methodology
 Observation and results
 Discussion
 Conclusion

3. Introduction
 In Ayurveda the branch which deals with preparation and
development of various dosage forms is Bhaishajya Kalpana,
here Bhaishajya stands for medicine and Kalpana for various
dosage forms like..
 Swarasa – Expressed herbal juice
 Kalka - Paste
 Kwatha- Decoction
 Asava and Arishta – Alcoholic preparation
 Vati – Tablets
 and Ghanavati- solidified extractive tablets

4. Ghanavati Kalpana
 In Ayurvedic classics,Ghanavati
is categorized under Rasakriya,
it is also considered as Phanita and
Avaleha, because their method of preparation is almost
same.
 These dosage forms are prepared by evaporating the water
content of aqueous solutions [Swarasa, Kwatha, Hima
and Phanta] and then made into Vati or powder if
necessary.

5. Aim and Objective
 To establish applicability of Ghanavati Kalpa as superior
and convenient dosage form and to compare Ghanavati
with Vati (prepared from powder) and modern extractive
tablets.

6. Methodology
 This is a literary study done by comparing various
references from classical texts, published articles on Vati &
Ghanavati and modern pharmaceutical texts.
 On the basis of studied information, different qualities and
properties of Ghanavati and vati were compared in view of
advantage and disadvantage to establish superiority of
dosage form.

7. Observation & Results

8. General Method of Ghanavati Preparation
 Herbal drug is crushed
 Mixed with 8 parts of water
 Boiled over moderate fire
 Reduced the liquid to 1/4th part
 Reduced liquid is filtered through a clean cloth
 The filtrate is boiled further to attain thicker consistency
 Thick sticky mass is obtained
 Mass is rolled into pills of desired size called Ghanavati

9. Modern View of Ghanavati
 Contain all water soluble extracts.
 Potent than herbal powders as fibre content is less.
 More proportion of phyto-constitutes.
 Veerya (active component)is more as per classical claim
and also represented by smell, taste and found in HPTLC
 Equivalent to modern tablets prepared from extracts.

10. Limitation of Vati (Tablet)
 It is less potent because of more fiber content.
 Accurate dose hampers due to more friability which
causes friction reduction during transportation.
 Particle size is more which decreases its absorption in
body.

11. Limitation of Powders (Churna)
 Low shelf life
 Accurate dose missing.
 Easy to get contaminated.
 Less potency due to more fiber content.
 Daily dose is high.
 Palatability is a major issue.
 Particle size is more.

12. Advantages of Ghanavati over Churna
and Vati
 Particle size reduction facilitates adequate mass transfer
for better extraction.
 More potent than Churna and Vati due to less fiber content
 Low dose is required.
 Easy to handling and transporting .
 Unit dosage form.
 Easy administration
 Palatability is more.

13. Few researches on Ghanavati Kalpana
S.No Research topic Author Result & Observation
1. Clinical study on evaluation of anti-cataract
effect of Triphaladi Ghana Vati and Elaneer
Kuzhambu Anjana in Timira (immature
cataract).
Dr. Hitesh Bhati Triphaladi ghanavati
found effective on
immature cataract.
2. Pharmacognostical and pharmaceutical assay of
Asanadi Ghanavati: An Ayurvedic polyherbal
Formulation
Dr. Shivam Joshi Pharmacognostical
findings matched with that
of individual
raw drugs with no major
change in the microscopic
structure of the raw drugs
during preparation of
ghanavati.
3. A PHARMACOGNOSTICAL AND
PHYSICO-CHEMICAL EVALUATION OF
PATOLADI GHANAVATI
Dr.Madhumita Panigrahi Pharmacognostical
findings of raw drugs
confirm the authentication
of ingredients present in
the finished product.

14. Discussion
 Drug efficacy depend on Bio-availability.
 Bio availability depend on few factors such as… particle
size, disintegration time, concentration of drug.
 Ghanavati Kalpana partice size is less as compared to
tablet and Churna
 Less disintegration time, releases more proportion of
active component in less time.
 Concentration of phyto-constitute is more.

15. Cont….
 Method of preparation is easy.
 Shelf life is more than that of Churna and Vati(tablets) .
 Handling feasibility is more, as hardness is more and not
breakable unlike tablets due to sticky nature of extracts
 Contains only water soluble constitutes hence can not be
prepared from drugs in which active constitute is oil or oil
soluble.

16. Conclusion
 Any dosage form can be taken as
superior only when it is better on
different aspects with another as it
should be convenient to administer as
well as it should be cheaper also same
way there should be low dose required
for same effect.
 On the basis of required qualities Ghanavati kalpa is
found superior on Vati and same qualities as of modern
extractive tablets.

17. References
 Shrikant Murthey K.R.,Sharangdahr Sanhita, Madhyam Khanada shloka –
8/1,first edition 2012,chaukhamba orientalia p.91
 Dr.Brahmanand tripathi, Charaka Samhitha With charaka chandrikahindi
Commentary, Varanasi: Choukambha surbharathi prakashan, reprint
2004.Sutra Sthana 20/11, Page-390.
 Acharya Vidhyadhar Shukla & Prof.Ravidutt Tripathi, Charaka Samhitha
With Vaidhya Manorama Commentary, Delhi: Choukambha Sanskrit
Pratishthan, Reprint 2007. Cikitsa Sthana 28/38-42, Page-694 & 695.
 Garde G.K. editor, sartha vaghbhata marathi comentary. in ashtang hridaya,
8th edition, pune, india. Raghuvanshi publication 1996 pg.85.
 Shrikant Murthey K.R.,Sharangdahr Sanhita, Madhyam Khanada shloka –
8/1,first edition 2012,chaukhamba orientalia p.91
 Shrikant Murthey K.R.,Sharangdahr Samhita, Madhyam Khanada shloka –
9/3-4,first edition 2012,chaukhamba orientalia p. 104

18.  To make any science more beneficial and superior, one
must discover and utilize superior path/applications.
Thank you